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Brian Litt, MD

Professor of Neurology and Professor of Bioengineering
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology

Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Graduate Group Affiliations
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
American Board of Clinical Neurophysiology (no expiration date), 1996.
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Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise


I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000

I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

Murphy BB, Scheid BH, Hendricks Q, Apollo NV, Litt B, Vitale F.: Time Evolution of the Skin-Electrode Interface Impedance under Different Skin Treatments. Sensors (Basel) 21: 5210, Jul 2021.

Bernabei JM, Arnold TC, Shah P, Revell A, Ong IZ, Kini LG, Stein JM, Shinohara RT, Lucas TH, Davis KA, Bassett DS, Litt B.: Electrocorticography and stereo EEG provide distinct measures of brain connectivity: implications for network models. Brain Commun 3: fcab156, Jul 2021.

Bernabei JM, Owoputi O, Small SD, Nyema NT, Dumenyo E, Kim J, Baldassano SN, Painter C, Conrad EC, Ganguly TM, Balu R, Davis KA, Levine JM, Pathmanathan J, Litt B.: A Full-Stack Application for Detecting Seizures and Reducing Data During Continuous Electroencephalogram Monitoring. Crit Care Explor 3: e0476, Jul 2021.

Ashourvan A, Shah P, Pines A, Gu S, Lynn C, Bassett DS, Davis KA, Litt B: Pairwise maximum entropy model explains the role of white matter structure in shaping emergent co-activation states. Nature Communications In press, January 2021.

Scheid BH, Ashourvan A, Stiso J, Davis KA, Mikhail F, Pasqualetti F, Litt B, Bassett DS: Time-evolving controllability of effective connectivity networks during seizure progression. Proceedings of the National Academy of Sciences In press, January 2021.

Driscoll N, Rosch RE, Murphy BB, Ashourvan A, Vishnubhotla R, Dickens OO, Johnson ATC, Davis KA, Litt B, Bassett DS, Takano H, Vitale F.: Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale. Commun Biol 4: 136, Jan 2021.

Ramayya AG, Yang AI, Buch VP, Burke JF, Richardson AG, Brandon C, Stein JM, Davis KA, Chen HI, Proekt A, Kelz MB, Litt B, Gold JI, Lucas TH.: Theta synchrony is increased near neural populations that are active when initiating instructed movement. eNeuro Neuro: online ahead of print, December 2020.

Baldassano SN, Roberson SW, Balu R, Scheid B, Bernabei JM, Pathmanathan J, Oommen B, Leri D, Echauz J, Gelfand M, Bhalla PK, Hill CE, Christini A, Wagenaar JB, Litt B.: IRIS: A Modular Platform for Continuous Monitoring and Caretaker Notification in the Intensive Care Unit. IEEE J Biomed Health Inform 24: 2389-2397, Aug 2020.

Conrad EC, Bernabei JM, Kini LG, Shah P, Mikhail F, Kheder A, Shinohara RT, Davis KA, Bassett DS, Litt B.: The sensitivity of network statistics to incomplete electrode sampling on intracranial EEG. Netw Neurosci 4: 484-506, May 2020.

Williams Roberson S, Shah P, Piai V, Gatens H, Krieger AM, Lucas TH 2nd, Litt B.: Electrocorticography reveals spatiotemporal neuronal activation patterns of verbal fluency in patients with epilepsy. Neuropsychologia 141: 107386, Apr 2020.

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Last updated: 08/24/2021
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