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Brian Litt, MD

Perelman Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology

Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Graduate Group Affiliations
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
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Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise


I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000

I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

Lucas A, Campbell Arnold T, Okar SV, Vadali C, Kawatra KD, Ren Z, Cao Q, Shinohara RT, Schindler MK, Davis KA, Litt B, Reich DS, Stein JM.: Multi-contrast high-field quality image synthesis for portable low-field MRI using generative adversarial networks and paired data. Radiology in revision, May 2024.

Gallagher RS, Sinha N, Pattnaik AR, Ojemann WKS, Lucas A, LaRocque JJ, Bernabei JM, Greenblatt AS, Sweeney EM, Chen HI, Davis KA, Conrad EC, Litt B.: Quantifying interictal intracranial EEG to predict focal epilepsy. Brain Communications in press, May 2024.

Xie K, Ojemann WKS, Gallagher RS, Lucas A, Hill CE, Hamilton RH, Johnson KB, Roth D, Litt B, Ellis CA.: Disparities in seizure outcomes revealed by large language models. Journal Am Med Inform Assoc. 13(ocae047), March 2024 Notes: doi: 10.1093/jamia/ocae047.

Lucas A, Scheid BH, Pattnaik AR, Gallagher R, Mojena M, Tranquille A, Prager B, Gleichgerrcht E, Gong R, Litt B, Davis KA, Das S, Stein JM, Sinha N.: iEEG-recon: A Fast and Scalable Pipeline for Accurate Reconstruction of Intracranial Electrodes and Implantable Devices. Epilepsia Dec 2023.

Emmert BE, Xie K, Conrad EC, Ghosn NJ, Bauman K, Korzun J, Kulick-Soper CV, Naveed O, Hartmann N, LaRocque JJ, Mindy Ganguly T, Gugger JJ, Raghupathi R, Gelfand MA, Davis KA, Sinha SR, Litt B, Shinohara RT, Ellis CA.: Alcohol for seizure induction in the epilepsy monitoring unit. Epilepsy Behav 150: 109572, Dec 2023.

Knight A, Gschwind T, Galer P, Worrell GA, Litt B, Soltesz I, Beniczky S.: Artificial Intelligence in Epilepsy Phenotyping. Epilepsia Nov 2023.

Xie K, Terman SW, Gallagher RS, Hill CE, Davis KA, Litt B, Roth D, Ellis CA.: Generalization of finetuned transformer language models to new clinical contexts. JAMIA Open 6: ooad070, Aug 2023.

Pattnaik AR, Ghosn NJ, Ong IZ, Revell AY, Ojemann WKS, Scheid BH, Georgostathi G, Bernabei JM, Conrad EC, Sinha SR, Davis KA, Sinha N, Litt B.: The seizure severity score: a quantitative tool for comparing seizures and their response to therapy. J Neural Eng 20, Aug 2023.

Decker BM, Ellis CA, Schriver E, Fischbein K, Smith D, Moyer JT, Kulick-Soper CV, Mowery D, Litt B, Hill CE.: Characterizing the treatment gap in the United States among adult patients with a new diagnosis of epilepsy. Epilepsia 64(7): 1862-1872, Jul 2023.

Ojemann WKS, Scheid BH, Mouchtaris S, Lucas A, LaRocque JJ, Aguila C, Ashourvan A, Caciagli L, Davis KA, Conrad EC, Litt B.: Resting-state background features demonstrate multidien cycles in long-term EEG device recordings. Brain Stimul Jul 2023.

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Last updated: 04/19/2024
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