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Brian Litt, MD

Professor of Neurology and Professor of Bioengineering
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology

Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Graduate Group Affiliations
Education:
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
Certifications
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
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Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise

Entrepreneurship:

I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000


I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

Revell AY, Silva AB, Arnold TC, Stein JM, Das SR, Shinohara RT, Bassett DS, Litt B, Davis KA.: A framework For brain atlases: Lessons from seizure dynamics. Neuroimage 254, Jul 2022.

Scheid BH, Aradi S, Pierson RM, Baldassano S, Tivon I, Litt B, Gonzalez-Alegre P.: Predicting Severity of Huntington's Disease With Wearable Sensors. Frontiers in Digital Health 4(4), April 2022.

Arnold TC, Baldassano SN, Litt B, Stein JM.: Simulated diagnostic performance of low-field MRI: Harnessing open-access datasets to evaluate novel devices. Magn Reson Imaging 87: 676-76, April 2022.

Revell AY, Silva AB, Arnold TC, Stein JM, Das SR, Shinohara RT, BAssett DS, Litt B, DAvis KA: A Framework for Brain Atlases: Lessons from Seizure Dynamics. Neuroimage In press, April 2022.

Ganguly TM, Ellis CA, Tu D, Shinohara RT, Davis KA, Litt B, Pathmanathan J.: Seizure Detection in Continuous Inpatient EEG: A Comparison of Human vs Automated Review. Neurology 11(10), April 2022 Notes: ePub ahead of print.

Scheid BH, Bernabei JM, hambhati AN, Mouchtaris S, Jeschke J, Bassett DS, Becker D, Davis KA, Lucas TA, Doyle W, Chang EF, Friedman D, Rao VR, Litt B.: Intracranial electroencephalographic biomarker predicts effective responsive neurostimulation for epilepsy prior to treatment. Epilepsia in press, January 2022.

Stiso J, Lynn CW, Kahn AE, Rangarajan V, Szymula KP, Archer R, Revell A, Stein JM, Litt B, Davis KA, Lucas TH, Bassett DS.: Neurophysiological evidence for cognitive map formation during sequence learning. eNeuro January 2022.

Stiso J, Lynn CW, Kahn AE, Rangarajan V, Szymula KP, Archer R, Revell A, Stein JM, Litt B, Davis KA, Lucas TH, Bassett DS.: Neurophysiological evidence for cognitive map formation during sequence learning. eNeuro 0361, Jan 2022 Notes: Online ahead of print.

Scheid BH, Bernabei JM, Khambhati AN, Mouchtaris S, Jeschke J, Bassett DS, Becker D, Davis KA, Lucas T, Doyle W, Chang EF, Friedman D, Rao VR, Litt B.: Intracranial electroencephalographic biomarker predicts effective responsive neurostimulation for epilepsy prior to treatment. Epilepsia Jan 2022.

Xie K, Gallagher RS, Conrad EC, Garrick CO, Baldassano SN, Bernabei JM, Galer PD, Ghosn NJ, Greenblatt AS, Jennings T, Kornspun A, Kulick-Soper KV, Panchall JM, Pattnaik1 AR, Scheid BH, Wei D, Weitzman M, Muthukrishnan R, Kim J, Litt B, Ellis CA, Roth D: Extracting Seizure Frequency From Epilepsy Clinic Notes: A Machine Reading Approach To Natural Language Processing. Journal of the American Medical Informatics Association in press, 2022.

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Last updated: 05/12/2022
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