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M. Sean Grady, M.D.

Charles Harrison Frazier Professor of Neurosurgery
Attending Neurosurgeon, The Children's Hospital of Philadelphia
CPUP Board of Directors, Hospital of the University of Pennsylvania
Chairman Department of Neurosurgery/Neurosurgeon in Chief, Hospital of the University of Pennsylvania
Neurosurgeon in Chief - Hospital of the University of Pennsylvania , University of Pennsylvania
University of Pennsylvania Chair and Directors Committee, Hospital of the University of Pennsylvania
Physician Director, Penn Neuroscience Service Line, The Hospital of The University of Pennsy1vania
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
clinical: 215.662.3483
administrative: 215.349.8325
Philadelphia, PA 19104
B.A. (Biology)
University of California, San Diego, 1977.
Georgetown University School of Medicine, 1981.
Post-Graduate Training
Intern, Department of Surgery, University of Virginia, Charlottesville, 1981-1982.
Resident , Neurological Surgery, University of Virginia, 1982-1987.
American Board of Neurological Surgery, 1990.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Dr. Grady's research interests include memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery.

Description of Clinical Expertise

Dr. Grady was appointed the Charles Harrison Frazier Professor & Chairman of the Department of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania in March 1999. He received his undergraduate degree from the University of California, San Diego and medical degree from Georgetown University School of Medicine. He trained in Neurological Surgery at the University of Virginia from 1981-1987 and was a faculty member at the University of Washington from 1987-1999. He is Board Certified by the American Board of Neurological Surgeons and is a fellow of the American College of Surgeons. Dr. Grady served as the Secretary for American Board of Neurological Surgery from 2004-2008, and was appointed Chairman of the ABNS from 2008-2009. Dr. Grady served as a member of the editorial board for the Journal of Neurosurgery from 2000-2010.

Dr. Grady's clinical focus is in the area of Cranial Base Tumors, Pituitary Tumors, Meningiomas, Schwannomas, Malignant Skull Base Tumors as well as Cerebrovascular Disorders, Aneurysms, AVM's. Dr. Grady and Dr. Bert O’Malley (Chairman, Department of Otorhinolaryngology - Head and Neck Surgery) are co-directors of the Cranial Base Center. In addition, Dr. Grady performs general neurosurgery procedures for herniated discs of the back and neck.

Description of Other Expertise

Philadelphia Magazine Top Doctors 2004-2011.

Selected Publications

Farquhar DR, Luke K, Worral D, Chiu A, Lee J YK, Grady MS, O'Malley BW, Newman JG, Kennedy D, Palmer J, Adappa N, Khalili SK: Propensity Score Analysis of Endoscopic and Open Approaches to Malignant Paranasal and Skull Base Tumor Outcomes The Laryngoscope Page: In Press, Dec 2015.

Massaro Allie M, Doerfler Sean, Nawalinski Kelsey, Michel Bernard, Driscoll Nicolette, Ju Connie, Patel Hiren, Quattrone Francis, Frangos Suzanne, Maloney-Wilensky Eileen, Sean Grady Michael, Stein Sherman C, Kasner Scott E, Kumar Monisha A: Thromboelastography Defines Late Hypercoagulability After TBI: A Pilot Study. Neurocritical care Aug 2014.

Xiong Guoxiang, Elkind Jaclynn A, Kundu Suhali, Smith Colin J, Antunes Marcelo B, Tamashiro Edwin, Kofonow Jennifer M, Mitala Christina M, Stein Sherman C, Grady M Sean, Einhorn Eugene, Cohen Noam A, Cohen Akiva S: Traumatic brain injury-induced ependymal ciliary loss decreases cerebral spinal fluid flow. Journal of neurotrauma 31(16): 1396-404, Aug 2014.

Lovatt Ditte, Ruble Brittani K, Lee Jaehee, Dueck Hannah, Kim Tae Kyung, Fisher Stephen, Francis Chantal, Spaethling Jennifer M, Wolf John A, Grady M Sean, Ulyanova Alexandra V, Yeldell Sean B, Griepenburg Julianne C, Buckley Peter T, Kim Junhyong, Sul Jai-Yoon, Dmochowski Ivan J, Eberwine James: Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue. Nature methods 11(2): 190-6, Feb 2014.

Macyszyn Luke, Lega Brad, Bohman Leif-Erik, Latefi Ahmad, Smith Michelle J, Malhotra Neil R, Welch William, Grady Sean M: Implementation of a departmental picture archiving and communication system: a productivity and cost analysis. Neurosurgery 73(3): 528-33, Sep 2013.

Ramakrishnan Vijay R, Suh Jeffrey D, Lee Jennifer Y, O'Malley Bert W, Grady M Sean, Palmer James N: Sphenoid sinus anatomy and suprasellar extension of pituitary tumors. Journal of neurosurgery 119(3): 669-74, Sep 2013.

Macyszyn Luke, Lega Brad, Bohman Leif-Erik, Latefi Ahmad, Smith Michelle J, Malhotra Neil R, Welch William, Grady M Sean: Implementation of a Departmental Picture Archiving and Communication System (PACS): A Productivity and Cost Analysis. Neurosurgery May 2013.

Lee John Y K, Barroeta Julieta E, Newman Jason G, Chiu Alexander G, Venneti Sriram, Grady M Sean: Endoscopic endonasal resection of anterior skull base meningiomas and mucosa: implications for resection, reconstruction, and recurrence. Journal of neurological surgery. Part A, Central European neurosurgery 74(1): 12-7, Jan 2013.

Yin Terry, Lindley Timothy E, Albert Gregory W, Ahmed Raheel, Schmeiser Peter B, Grady M Sean, Howard Matthew A, Welsh Michael J: Loss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injury. PloS one 8(8): e72379, 2013.

Grady MS, Lee J, O'Malley B, Palmer J, Ramakrishnan V: Sphenoid Sinus Anatomy and Suprasellar Extension of Pituitary Tumors. Journal of Neurosurgery 2013.

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Last updated: 05/30/2018
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