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Ethan M. Goldberg, M.D., Ph.D.

Associate Professor of Neurology
Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia
Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 502A
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Graduate Group Affiliations
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
American Board of Psychiatry and Neurology (ABPN), 2013.
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Description of Clinical Expertise

Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Gracia-Diaz, C., Perdomo, J.E., Kham, M.E., Disanza, B., Cajka, G.G., Lei, S., Gagne, A., Maguire, J.A., Roule, T., Shalem, O., Bhoj, E.J., Ahrens-Nicklas, R.C., French, D., Goldberg, E.M., Wang, K., Glessner, J., Akizu, N.: High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs Cell Stem Cell 2024.

Rosenberg, E.C., Goldberg, E.M.: Don't Give Me Lip: A Role for Lipid-Accumulated Reactive Astrocytes in Temporal Lobe Epilepsy. Epilepsy Currents 23(5): 321-323, June 2023.

Goff, K.M., Liebergall, S.R., Jiang, E., Somarowthu, A., Goldberg, E.M.: VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome. Cell Reports 42(6), Jun 2023.

Fadila, S., Beucher, B., González-Dopeso Reyes, I., Mavashov, A., Brusel, M., Anderson, K., Goldberg, E.M., Ricobaraza, A., Hernandez-Alcoceba, R., Kremer, E.J., Rubinstein, M.: Exogenous NaV1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with Dravet. J Clin Invest 133(12), June 2023.

Clatot, J., Ginn, N., Costain, G., Goldberg, E.M.: A KCNC1-related neurological disorder due to gain of Kv3.1 function. Ann Clin Trans Neurol Jan 2023.

Kravchenko, J.A., Goldberg, E.M., Mattis, J.: Optogenetic and chemogenetic manipulation of seizure threshold in mice. STAR Protoc 4(1): 102019, Jan 2023.

Kayumi, S., Pérez-Jurado, L.A., Palomares, M., Rangu, S., Sheppard, S.E., Chung, W.K., Kruer, M.C., Kharbanda, M., Amor, D.J., McGillivray, G., Cohen, J.S., García-Miñaúr, S., van Eyk, C.L., Harper, K., Jolly, L.A., Webber, D.L., Barnett, C.P., Santos-Simarro, F., Pacio-Míguez, M., del Pozo, A., Bakhtiari, S., Deardorff, M., Dubbs, H.A., Izumi, K., Grand, K., Gray, C., Mark, P.R., Bhoj, E.J., Li, D., Ortiz-Gonzalez, X.R., Keena, B., Zackai, E.H., Goldberg, E.M., Perez de Nanclares, G., Pereda, A., Llano-Rivas, I., Arroyo, I., Fernández-Cuesta, M.A., Thauvin-Robinet, C., Faivre, L., Garde, A., Mazel, B., Bruel, A.-L., Tress, M.L., Brilstra, E., Fine, A.S., Crompton, K.E., Stegmann, A.P.A., Sinnema, M., Stevens, S.C.J., Nicolai, J., Lesca, G., Lion-François, L., Haye, D., Chatron, N., Piton, A., Nizon, M., Cogne, B., Srivastava, S., Bassetti, J., Muss, C., Gripp, K.W., Procopio, R.A., Millan, F., Morrow, M.M., Assaf, M., Moreno-De-Luca, A., Joss, S., Hamilton, M.J., Bertoli, M., Foulds, N., McKee, S., MacLennan, A.H., Gecz, J., Corbett, M.: Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants. Genetics in Medicine 24(11): 2351-2366, November 2022.

Clatot, J., Parthasarathy., S, Cohen., S, McKee., J.L., Massey, S., Somarowthu, A., Goldberg, E.M. Helbig, I.: SCN1A gain-of-function mutation causing an early onset epileptic encephalopathy. Epilepsia Page: 1-3, October 2022 Notes:

Goff, K.M., Jiang, E., Somarowthu, A., Goldberg, E.M.: VIP interneuron dysfunction underlies impaired neocortical state transitions and behavior in a model of Dravet syndrome (38) Poster presentation at the Gordon Research Conference: Mechanisms of Epilepsy and Neuronal Synchronization. Barcelona, Spain. July 2022.

Lawlor, P.N., Goldberg, E.M.: Dynamic fluorescence imaging in experimental epilepsy Epilepsy Currents 22(6), Jul 2022.

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Last updated: 02/15/2024
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