Ethan M. Goldberg - Faculty Biosketch

Ethan M. Goldberg, M.D., Ph.D.

Associate Professor of Neurology

Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia

Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania

Department: Neurology

Contact information

The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 510D
3615 Civic Center Boulevard
Philadelphia, PA 19104

Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671

Email:
goldberge@email.chop.edu

Graduate Group Affiliations

Neuroscience

Publications

Search PubMed for articles

Links
Search PubMed for articles
Division of Neurology, The Children's Hospital of Philadelphia
Goldberg Lab Web Link
The Epilepsy Neurogenetics Initiative (ENGIN) Web Link

Education:
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.

Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.

Certifications
American Board of Psychiatry and Neurology (ABPN), 2013.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Edmondson, A.C., Budhraja, R., Xia, Z., Melendez-Perez, A., Cai, C., Radenkovic, S., Collins, A.M., Shiplett, E.J., Hill, S.F., Somarowthu, A., Dam, J., Pai, L.L., Santi, M., Kim, S., He, M., Goldberg, E.M., Kozicz, T., Morava, E., Pandey, A., Zhou, Z.: Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology. bioRxiv 2025.06.01.657261; doi: https://doi.org/10.1101/2025.06.01.657261 Jun 2025.

Clatot, J., Thompson, C.H., Susan Sotardi, S., Jiang, J., Trivisano, M., Balestrini, S., Ward, I., Ginn, N., Guaragni, B., Malerba, L., Vakrinou, A., Sherer, M., Helbig, I., Somarowthu, A., Sisodiya, S.M., Ben-Shalom, R., Guerrini, R., Specchio, N., George, Jr., A.L., Goldberg, E.M.: Rare dysfunctional SCN2A variants are associated with malformation of cortical development. Epilepsia 66(3): 914-928, Mar 2025.

Wengert, E.R., Cheng, M.A., Liebergall, S.R., Markwalter, K.H., Hong, Y., Arias, L., Marsh, E.D., Zhang, X., Somarowthu, A., Goldberg, E.M.: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy. eLife 13(RP103784), December 2024 Notes: https://doi.org/10.7554/eLife.103784.1

Rosenthal, Z., Joseph Majeski, J., Somarowthu, A., Quinn, D., Lindquist, D., Putt, M., Karaj, A., Favilla, C., Baker, W., Hosseini, G., Rodriguez, J., Cristancho, M., Sheline, Y., Shuttleworth, Abbott, C., Yodh, A., Goldberg, E.M.: Electroconvulsive therapy generates a hidden wave after seizure. bioRxiv November 2024 Notes: doi.org/10.1101/2024.10.31.621357.

Hill, S.F., Wengert, E.R., Goldberg, E.M., Theyel, B.: Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome. bioRxiv 2024.09.30.615811, October 2024 Notes: doi: https://doi.org/10.1101/2024.09.30.615811

Furlanis, E., Dai, M., Garcia, B.L., Vergara, J., Pereira, A., Pelkey, K., Tran, T., Gorissen, B.L., Vlachos, A., Hairston, A., Huang, S., Dwivedi, D., Du, S., Wills, S., McMahon, J., Lee, A.T., Chang, E.F., Razzaq, T., Qazi, A., Vargish, G., Yuan, X., Caccavano, A., Hunt, S., Chittajallu, R., McLean, N., Hewit, L., Paranzino, E., Rice, H., Cummins, A.C., Plotnikova, A., Mohanty, A., Tangen, A.C., Shin, J.H., Azadi, R., Eldridge, M.A.G. Alvarez, V.A., Averbeck, B.B., Alyahyay, M., Vallejo, T.R., Soheib, M., Vattino, L.G., MacGregor, C.P., Banks, E., Olah, V.J., Naskar, S., Hill, S., Liebergall, S., Badiani, R., Hyde, L., Xu, Q., Allaway, K.C., Goldberg, E.M., Nowakowski, T.J., Lee, S., Takesian, A.E., Ibrahim, L.A., Iqbal, A., McBain, C.J., Dimidschstein, J., Fishell, G., Wang, Y.: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. bioRxiv 2024.07.17.603924, July 2024 Notes: doi.org/10.1101/2024.07.17.603924.

Dabrowski, A.K., Goldberg, E.M.: A human touch: Hominid-specific LRRC37B regulates axon initial segment excitability Epilepsy Currents 24(4): 286-288, Jul-Aug 2024.

Qu, G., Merchant, J.P., Clatot, J., DeFlitch, L., Frederick, D., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S.A., Goldberg, E.M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, April 2024.

Liebergall S.R., Goldberg, E.M. : Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome. J Neurosci 44(17): e1977232024, April 2024.

Clatot, J., Goldberg, E.M.: No Pain, No Gain of Function: Epilepsy-Associated Variants in SCN2A Defy Classification Epilepsy Currents 24(2): 126-128, Mar-Apr 2024.