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Ethan M. Goldberg, M.D., Ph.D.

Associate Professor of Neurology
Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia
Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 510D
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Graduate Group Affiliations
Education:
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
Certifications
American Board of Psychiatry and Neurology (ABPN), 2013.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Dabrowski, A.K., Goldberg, E.M.: A human touch: Hominid-specific LRRC37B regulates axon initial segment excitability Epilepsy Currents 24(4), Jul-Aug 2024.

Liebergall S.R., Goldberg, E.M. : Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome. J Neurosci 44(17): e1977232024, Apr 2024.

Qu, G., Merchant, J.P., Clatot, J., DeFlitch, L., Frederick, D., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S.A., Goldberg, E.M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, Apr 2024.

Clatot, J., Goldberg, E.M.: No Pain, No Gain of Function: Epilepsy-Associated Variants in SCN2A Defy Classification Epilepsy Currents 24(2): 126-128, Mar-Apr 2024.

Gracia-Diaz, C., Perdomo, J.E., Kham, M.E., Disanza, B., Cajka, G.G., Lei, S., Gagne, A., Maguire, J.A., Roule, T., Shalem, O., Bhoj, E.J., Ahrens-Nicklas, R.C., French, D., Goldberg, E.M., Wang, K., Glessner, J., Akizu, N.: High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs Cell Stem Cell 31(3): 288-289, Mar 2024.

Feng, H., Clatot, J., Kaneko, K., Flores-Mendez, M., Wengert, E.R., Koutcher, C., Hoddeson, E., Lopez, E., Lee, D., Arias, L., Liang, Q., Zhang, X., Somarowthu, A., Covarrubias, M., Gunthorpe, M.J., Large, C.H.., Akizu, N., Goldberg, E.M.: Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy. Cell Reports Medicine 4(2): 101389, Feb 2024.

Clatot, J., Currin, C.B., Liang, Q., Pipatpolkai, T., Massey, S.L., Helbig, I., Delemotte, L., Vogels, T.P., Covarrubias, M., Goldberg, E.M.: A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. PNAS 121(3): e2307776121, Jan 2024.

Waxman, E., Dungan, L., DeFlitch, L., Merchant, J., Gagne, A., Goldberg, E.M., French, D.: A Reproducible Protocol for Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Excitatory Cortical Neuron Cultures with Checkpoints for Success. Current Protocols 3(12): e948, Dec 2023.

Rosenberg, E.C., Goldberg, E.M.: Don't Give Me Lip: A Role for Lipid-Accumulated Reactive Astrocytes in Temporal Lobe Epilepsy. Epilepsy Currents 23(5): 321-323, June 2023.

Goff, K.M., Liebergall, S.R., Jiang, E., Somarowthu, A., Goldberg, E.M.: VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome. Cell Reports 42(6), Jun 2023.

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Last updated: 07/10/2024
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