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Ethan M. Goldberg, M.D., Ph.D.

Assistant Professor of Neurology
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 502A
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Graduate Group Affiliations
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
American Board of Psychiatry and Neurology (ABPN), 2013.
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Description of Clinical Expertise

Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Kaneko, K., Currin, C.B., Goff, K.M., Somarowthu, A., Vogels, T.P., Goldberg, E.M.: Developmentally-regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome. bioRxiv 2021.07.28.454042, July 2021.

Fitzgerald, M.P., Kaufman, M.C., Massey, S.L., Fridinger, S., Prelack, M., Ellis, C., Ortiz-Gonzalez, X., Fried, L.E., DiGiovine, M.P.; CHOP Pediatric Epilepsy Program Collaborative, Melamed, S., Malcolm, M., Banwell, B., Stephenson, D., Witzman, S.M., Gonzalez, A., Dlugos, D., Kessler, S.K., Goldberg, E.M., Abend, N.S., Helbig, I.: Assessing seizure burden in pediatric epilepsy using an electronic medical record-based tool through a common data element approach. Epilepsia 62(7): 1617-1628, July 2021.

Helbig KL, Goldberg EM.: SCN3A-Related Neurodevelopmental Disorder. GeneReviews® [Internet]. Available from: Adam MP, Ardinger HH, Pagon RA, et al. (eds.). Seattle (WA): University of Washington, Seattle; 1993-2021. June 2021.

Mcgarry, L.M., Goldberg, E.M.: The Course of Inhibition Never Did Run Smooth: Parvalbumin Interneuron Dysfunction in a Mouse Model of Lissencephaly. Epilepsy Currents OnlineFirst, May 2021.

Mattis, J.H., Somarowthu, A., Goff, K.M., Yom, J., Sotuyo, N.P., McGarry, L.M., Feng, H., Kaneko, K., Goldberg, E.M.: Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome. bioRxiv 2021.05.01.442271, May 2021.

Goff, K.M., Goldberg, E.M.: A Role for VIP Interneurons in Neurodevelopmental Disorders. Developmental Neuroscience Page: 1-13. April 2021 Notes: doi: 10.1159/000515264. Online ahead of print.

Goldberg, E.M.: Getting a foot IN the door: GABAergic INterneuron-specific enhancers. Epilepsy Currents 21(2): 114-116, March 2021.

Somarowthu, A., Goff, K.M., Goldberg, E.M.: Two-photon calcium imaging of seizures in awake, head-fixed mice. Cell Calcium 96: 102380, February 2021.

Muir, A.M., Gardner, J.F., van Jaarsveld, R.H., de Lange, I.M., van der Smagt, J.J., Wilson, G.N., Dubbs, H., Goldberg, E.M., Zitano, L., Bupp, C., Martinez, J., Srour, M., Accogli, A., Alhakeem, A., Meltzer, M., Gropman, A., Brewer, C., Caswell, R.C., Montgomery, T., McKenna, C., McKee, S., Powell, C., Vasudevan, P.C., Brady, A.F., Joss, S., Tysoe, C., Noh, G., Tarnopolsky, M., Brady, Zafar, M., Schrier Vergano, S.A., Murray, B., Sawyer, L., Hainline, B.E., Sapp, K., Demarzo, D., Huismann, D.J., Wentzensen, I.M., Schnur, R.E., Monaghan, K.G., Juusola, J., Rhodes, L., Dobyns, W.B., Lecoquierre, F., Goldenberg, A., Polster, T., Axer-Schaefer, S., Platzer, K., Klöckner, C., Hoffman, T.L., MacArthur, D.G., O’Leary, M.C., VanNoy, G.E., England, E., Varghese, V.C., Mefford, H.C.: Variants in GNAI1 Cause a Syndrome Associated with Variable Features including Developmental Delay, Seizures and Hypotonia. Genetics in Medicine 17(1): e1009214, January 2021.

Helbig, I., Goldberg, E.M.: The dose makes the poison – novel insights into Dravet Syndrome and SCN1A regulation through non-productive splicing. PLOS Genetics 17(1): e1009214, January 2021.

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Last updated: 09/11/2021
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