Penn Medicine
Help | Search | Site Map | Contact   
faculty photo

Ethan M. Goldberg, M.D., Ph.D.

Associate Professor of Neurology
Director, The Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia
Member, Computational Neuroscience Initiative (CNI), The University of Pennsylvania
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 510D
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Graduate Group Affiliations
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Cert. (Research Mentor Training: Center for the Improvement of Mentored Experiences in Research (CIMER))
University of Wisconsin-Madison , 2022.
Cert. (Raising a Resilient Scientist Series)
National Institutes of Health (NIH) Office of Intramural Training & Education (OITE), 2023.
Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident in Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Fellow in Epilepsy Research, The Children's Hospital of Philadelphia, 2013-2015.
American Board of Psychiatry and Neurology (ABPN), 2013.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay; Autism Spectrum Disorder.

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Dabrowski, A.K., Goldberg, E.M.: A human touch: Hominid-specific LRRC37B regulates axon initial segment excitability Epilepsy Currents 24(4), Jul-Aug 2024.

Liebergall S.R., Goldberg, E.M. : Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome. J Neurosci 44(17): e1977232024, Apr 2024.

Qu, G., Merchant, J.P., Clatot, J., DeFlitch, L., Frederick, D., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S.A., Goldberg, E.M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, Apr 2024.

Clatot, J., Goldberg, E.M.: No Pain, No Gain of Function: Epilepsy-Associated Variants in SCN2A Defy Classification Epilepsy Currents 24(2): 126-128, Mar-Apr 2024.

Gracia-Diaz, C., Perdomo, J.E., Kham, M.E., Disanza, B., Cajka, G.G., Lei, S., Gagne, A., Maguire, J.A., Roule, T., Shalem, O., Bhoj, E.J., Ahrens-Nicklas, R.C., French, D., Goldberg, E.M., Wang, K., Glessner, J., Akizu, N.: High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs Cell Stem Cell 31(3): 288-289, Mar 2024.

Feng, H., Clatot, J., Kaneko, K., Flores-Mendez, M., Wengert, E.R., Koutcher, C., Hoddeson, E., Lopez, E., Lee, D., Arias, L., Liang, Q., Zhang, X., Somarowthu, A., Covarrubias, M., Gunthorpe, M.J., Large, C.H.., Akizu, N., Goldberg, E.M.: Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy. Cell Reports Medicine 4(2): 101389, Feb 2024.

Clatot, J., Currin, C.B., Liang, Q., Pipatpolkai, T., Massey, S.L., Helbig, I., Delemotte, L., Vogels, T.P., Covarrubias, M., Goldberg, E.M.: A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. PNAS 121(3): e2307776121, Jan 2024.

Waxman, E., Dungan, L., DeFlitch, L., Merchant, J., Gagne, A., Goldberg, E.M., French, D.: A Reproducible Protocol for Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Excitatory Cortical Neuron Cultures with Checkpoints for Success. Current Protocols 3(12): e948, Dec 2023.

Rosenberg, E.C., Goldberg, E.M.: Don't Give Me Lip: A Role for Lipid-Accumulated Reactive Astrocytes in Temporal Lobe Epilepsy. Epilepsy Currents 23(5): 321-323, June 2023.

Goff, K.M., Liebergall, S.R., Jiang, E., Somarowthu, A., Goldberg, E.M.: VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome. Cell Reports 42(6), Jun 2023.

back to top
Last updated: 07/10/2024
The Trustees of the University of Pennsylvania
© The Trustees of the University of Pennsylvania. Site best viewed with a supported browser.
SOM Home International Programs Penn Alumni Clinical Trials Centers and Institutes Departments Faculty Research Education Administration