Dennis J. Dlugos - Faculty Biosketch

Dennis J. Dlugos, MD, MSCE

Professor of Neurology at the Children's Hospital of Philadelphia

Director, Pediatric Epilepsy Program, Division of Neurology, The Children's Hospital of Philadelphia

Associate Dean for UME Science and Discovery Curriculum, Perelman School of Medicine at the University of Pennsylvania

Department: Neurology

Contact information

Division of Neurology
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
The Hub for Clinical Collaboration
10th floor, Room 10537
Philadelphia, PA 19104

Office: 215-590-1719

Email:
dlugos@email.chop.edu

Education:
B.A. (Theology)
Loyola Marymount University, Los Angeles, CA, 1983.
M.D. (Medicine)
Columbia University College of Physicians & Surgeons, New York, NY, 1988.
M.S.C.E (Clinical Epidemiology)
Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.

Post-Graduate Training
Intern in Pediatrics, National Naval Medical Center, Bethesda, MD, 1988-1989.
Resident in Pediatrics, Thomas Jefferson University & Alfred I. Dupont Institute, Philadelphia, PA & Wilmington, DE, 1993-1994.
Resident in Neurology/Child Neurology, University of Pennsylvania Medical Center & The Children’s Hospital of Philadelphia, Philadelphia , 1994-1997.
Fellow in Epilepsy and Clinical Neurophysiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1997-1999.

Certifications
Pediatrics (1998 - 2012), American Board of Pediatrics, 1998.
Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology, 1998.
Clinical Neurophysiology with Special Qualifications in Epilepsy Monitoring, American Board of Clinical Neurophysiology, 1999.
Clinical Neurophysiology (1999-2009), American Board of Psychiatry and Neurology, 1999.
Epilepsy, American Board of Psychiatry and Neurology, 2013.

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Description of Research Expertise

Epilepsy Epidemiology
Epilepsy Genetics
Clinical Prediction Models

Description of Clinical Expertise

Pediatric Epilepsy
Epilepsy Genetics
Epilepsy Surgery
EEG
Clinical Neurophysiology

Selected Publications

Omurtag A, Abdulbaki S, Thesen T, Waechter R, Landon B, Evans R, Dlugos D, Chari G, LaBeaud AD, Hassan YI, Fernandes M, Blackmon K: Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG. Scientific Reports 15: 6346, 2025.

Jandhyala N, Ferrer Socorro M, Greenwood H, Pellinen J, Dlugos D, Park K, Thio L, French J: Unrecognized Focal Non-Motor Seizures in Adolescents Presenting to Emergency Departments. Neurology 102: e209389, 2024.

Ellis CA, Tu D, Oliver KL, Mefford HC, Hauser WA, Buchhalter J, Epstein MP, Cao Q, EPGP Consortium (including Dlugos DJ), Epi4K Consortium (including Dlugos DJ), Berkovic SF, Ottman R: Familial aggregation of seizure outcomes in four familial epilepsy cohorts. Epilepsia Page: 10.1111/epi.18004, 2024.

Epi4K Consortium (including Dlugos DJ): The role of copy number variants in the genetic architecture of common familial epilepsies. Epilepsia 65: 792-804, 2024.

Perry MS, Scheffer IE, Sullivan J, Brunklaus A, Boronat S, Wheless J, Laux L, Patel AD, Roberts CM, Dlugos D, Holder D, Knupp KG, Lallas1 M, Phillips S, Segal E, Smeyers P, Lal1 D, Wirrell E, Zuberi S, Brünger T, Wojnaroski M, Maru B, O’Donnell P, Morton M, James E, Vila C, Huang N, Gofshteyn JS, Rico S: Severe Communication Delays Are Independent of Seizure Burden and Persist Despite Contemporary Treatments in SCN1A+ Dravet Syndrome: Insights from the ENVISION Natural History Study. Epilepsia 65: 322-337, 2024.

Bozorg A, Beller C, Jensen L, Arzimanoglou A, Chiron C, Dlugos D, Gaitanis J, Wheless J, McClung C: Pitfalls of Using Video-EEG for a Trial Endpoint in Children Aged <4 Years with Focal Seizures. Annals of Clinical and Translational Neurology Page: 10.1002/acn3.51999, 2024.

Molisani SE, Parikh D, DiGiovine M, Dlugos D, Fitzgerald MP, Fried L, Helbig I, Kessler SK, McDonnell PP, Melamed S, Prelack MS, Sharif U, Tefft S, Tencer J, Witzman S, Shaw K, Abend NS: A quality improvement initiative to improve folic acid supplementation counseling for adolescent females with epilepsy. Epilepsia Page: 10.1111/epi.17723, July 2023.

International League Against Epilepsy Consortium on Complex Epilepsies (including Dlugos DJ) : GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nature Genetics 55: 1471-1482, 2023.

Bases B, Barnard S, French JA, Pellinen J; Human Epilepsy Project (including Dlugos DJ): Impact of Seizures While Driving Prior to Diagnosis in People With Focal Epilepsy: Motor Vehicle Accidents and Time to Diagnosis. Neurology 101: e1370-1375, 2023.

Montanucci L, Lewis-Smith D, Collins RL, Niestroj LM, Parthasarathy S, Xian J, Ganesan S, Macnee M, Brünger T, Thomas RH, Talkowski M; Epi25 Collaborative (including Dlugos DJ); Helbig I, Leu C, Lal D.: Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals. Nature Communications 14: 4392, 2023.