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Selected Publications
15e
Abramowitz SA, Hoffman-Andrews L, Zhang D, Judy R, Cappola TP, Day SM, Reza N, Owens AT, Damrauer SM, Levin MG; Penn Medicine BioBank: Polygenic background and penetrance of pathogenic variants in hypertrophic and dilated cardiomyopathies. JAMA Cardiol Page: e254739, Dec 2025.
15e
Vajargah KK, Dib MJ, Tavolinejad H, Zamani P, Richards AM, Mann DL, Rietzschel E, van Empel V, Burgess S, Cappola TP, Chirinos JA.: Proteome-Wide Genetic Investigation of Kidney Function in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail Page: 102771, Nov 2025.
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Woerner J, Westbrook TM, Joo J, Shivakumar M, Venkatesh R, Cherlin T, Jung SH, Jeong S, Maseda D, McKeague M, Shwetank, Ionita M, Wagenaar J, Abramowitz SA, Verma A, Zhao B, Lee S, Damrauer S, Levin MG, Heo SC, Cappola TP, Rader DJ, Day S, Deo R, Gelfand JM, Ramessur R, Guerraty MA, Setia-Verma S, Pasaniuc B, Ritchie MD, Apostolidis SA, Greenplate AR, Wherry EJ; Penn Medicine Biobank; Nam Y, Kim D.: Large-scale evaluation of proteomic and polygenic risk scores reveals complementary contributions to incident disease prediction.
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medRxiv [Preprint] Page: 25331242, Jul 2025.
1d0
Lindholm ME, Abramowitz S, Waggott DM, Grove ME, Dewey FE, Pan C, Pavlovic A, Shang C, Huang Y, Bensabath L, Goldfeder RL, Cordero P, Erbilgin A, Priest JR, Chaib H, Puckelwartz MJ, Day SM, McNally EM, Cappola T, Dorn GW, Ashley EA, Wheeler MT: Identification of candidate cardiomyopathy modifier genes through genome sequencing and RNA profiling. Front Cardiovasc Med 12: 1546493, Jul 2025.
256
Lee DSM, Cardone KM, Zhang DY, Abramowitz S, DePaolo JS, Aragam KG, Biddinger K, Conery M, Dilitikas O, Hoffman-Andrews L, Judy RL, Khan A, Kulo I, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P; Regeneron Genetics Center; Arany ZP, Cappola TP, Carruth E, Day SM, Do R, Haggarty CM, Joseph J, McNally E, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun Y, Voight BF, Levin MG, Damrauer SM.: Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum. Nat Genet 57(4): 829, Apr 2025.
896
Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Malarstig A, Gratton J, Bond I, Roselli C, Miller D, Chopade S, Schmidt AF, Abner E, Adams L, Andersson C, Aragam KG, Ärnlöv J, Asselin G, Raja AA, Backman JD, Bartz TM, Biddinger KJ, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunak S, Bruun MT, Buckbinder L, Bundgaard H, Carey DJ, Chasman DI, Chen X, Cook JP, Czuba T, de Denus S, Dehghan A, Delgado GE, Doney AS, Dörr M, Dowsett J, Dudley SC, Engström G, Erikstrup C, Esko T, Farber-Eger EH, Felix SB, Finer S, Ford I, Ghanbari M, Ghasemi S, Ghouse J, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Hägg S, Haggerty CM, Hedman ÅK, Helgadottir A, Hemingway H, Hillege H, Hyde CL, Aagaard Jensen B, Jukema JW, Kardys I, Karra R, Kavousi M, Kizer JR, Kleber ME, Køber L, Koekemoer A, Kuchenbaecker K, Lai YP, Lanfear D, Langenberg C, Lin H, Lind L, Lindgren CM, Liu PP, London B, Lowery BD, Luan J, Lubitz SA, Magnusson P, Margulies KB, Marston NA, Martin H, März W, Melander O, Mordi IR, Morley MP, Morris AP, Morrison AC, Morton L, Nagle MW, Nelson CP, Niessner A, Niiranen T, Noordam R, Nowak C, O'Donoghue ML, Ostrowski S, Owens AT, Palmer C, Paré G, Pedersen O, Perola M, Pigeyre M, Psaty BM, Rice KM, Ridker PM, Romaine SPR, Rotter JI, Ruff CT, Sabatine M, Sallah N, Salomaa V, Sattar N, Shalaby AA, Shekhar A, Smelser DT, Smith NL, Sørensen E, Srinivasan S, Stefansson K, Sveinbjörnsson G, Svensson P, Tammesoo M , Tardif JC , Teder-Laving M , Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Tragante V, Trompet S, Uitterlinden AG, Ullum H, van der Harst P, van Heel D, Jvan Setten J, van Vugt M, Veluchamy A, Verschuuren M, Verweij N, Vissing CR, Völker U, Voors AA, Wallentin L, Wang Y, Peter E Weeke, Wiggins KL, Williams LK, Yang Y, Yu B, Zannad F, Zheng C; Genes & Health Research Team; Estonian Biobank Research Team; DBDS Genomic Consortium; Asselbergs FW, Cappola TP, Dubé MP, Dunn ME, Lang CC, Samani N, Shah S, Vasan RS, Smith G, Holm H, Shah S, Ellinor PT, Hingorani AD, Wells Q, Lumbers RT; HERMES Consortium
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2
b3
: Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Nat Genet 57(4): 815, Apr 2025.
176
Chadwick J, Hinterberg MA, Asselbergs FW, Biegel H, Boersma E, Cappola TP, Chirinos JA, Coresh J, Ganz P, Gordon DA, Kureshi N, Loupey KM, Orlenko A, Ostroff R, Sampson L, Shrestha S, Sweitzer NK, Williams SA, Zhao L, Kardys I, Lanfear DE: Harnessing the Plasma Proteome to Predict Mortality in Heart Failure Subpopulations
42
Circ Heart Fail 18(4): e011208, Apr 2025.
18e
Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C, Mohanty I, Miyake MM, Adusumalli S, Margulies KB, Prenner SB, Poole DC, Wilson N, Reddy R, Townsend RR, Ischiropoulos H, Cappola TP, Chirinos JA: Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
3b
JAMA Cardiol 10(3): 284, Mar 2025.
17e
Tan K, Tay D, Tan W, Ng HK, Wong E, Morley MP, Singhera GK, Lee CJM, Jain PR, Tai FL, Hanson PJ, Cappola TP, Margulies KB, Foo R, Loh M: Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk.
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4e
Clin Epigenetics 17(1): s13148-025-01854-8, Mar 2025.
191
Gan S, Azzo JD, Zhao L, Pourmussa B, Dib MJ, Salman O, Erten O, Ebert C, Richards AM, Javaheri A Mann DL, Rietzschel E, Zamani P, van Empel V, Cappola TP, Chirinos JA: Transferrin Saturation, Serum Iron, and Ferritin in Heart Failure: Prognostic Significance and Proteomic Associations. Circ Heart Fail 18(2): e011728, Feb 2025.
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