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Kenneth B. Margulies, M.D.

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Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Attending Cardiologist, University of Pennsylvania Health System
Director, Penn Heart Failure and Transplant Research
Director of Cardiology Clinical Research Unit, UPenn, Division of Cardiology
Department: Medicine

Contact information
Heart Failure and Transplant Research
Translational Research Center
3400 Civic Center Blvd, Building 421
11th floor, Room 11-101
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-573-2980
Fax: 215-898-3473
Graduate Group Affiliations
Education:
A.B. (Politics)
Princeton University, 1982.
M.D. (Medicine)
Jefferson Medical College, 1986.
Post-Graduate Training
Resident, Internal Medicine, Mayo Graduate School of Medicine Rochester, MN, 1986-1989.
Clinical Investigator Trainee, Mayo Graduate School of Medicine Rochester, MN, 1989-1993.
NIH Research Fellow, Cardiovascular Diseases, Mayo Clinic Rochester, MN, 1989-1990.
Clinical Cardiology Fellow, Mayo Graduate School of Medicine, Rochester, MN, 1989-1993.
Certifications
Internal Medicine, ABIM, 1989.
Cardiovascular Diseases, ABIM, 1993.
Advanced Heart Failure and Transplant Cardiology, ABIM, 2010.
Cardiovascular Diseases (Recertification), ABIM , 2015.
Advanced Heart Failure and Transplantation Subspecialty Certification, 2021.
Permanent link
 
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Selected Publications

McAfee Q, Caporizzo MA, Uchida K, Bedi KC Jr, Margulies KB, Arany Z, Prosser BL. : Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force. Journ Clin Invest. Nov. 2023.

Wang Q, Tang TM, Youlton N, Weldy CS, Kenney AM, Ronen O, Hughes JW, Chin ET, Sutton SC, Agarwal A, Li X, Behr M, Kumbier K, Moravec CS, Tang WHW, Margulies KB, Cappola TP, Butte AJ, Arnaout R, Brown JB, Priest JR, Parikh VN, Yu B, Ashley EA. : Epistasis regulates genetic control of cardiac hypertrophy. medRxiv [Preprint] Nov. 2023.

Guilbaud A, Ghanegolmohammadi F, Wang Y, Leng J, Kreymerman A, Gamboa Varela J, Garbern J, Elwell H, Cao F, Ricci-Blair EM, Liang C, Balamkundu S, Vidoudez C, DeMott MS, Bedi K, Margulies KB, Bennett DA, Palmer AA, Barkley-Levenson A, Lee RT, Dedon PC: Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans. Nucleic Acids Res. Nov 2023.

Narayan V, Liu T, Song Y, Mitchell J, Sicks J, Gareen I, Sun L, Denduluri S, Fisher C, Manikowski J, Wojtowicz M, Vadakara J, Haas N, Margulies KB, Ky B: Early Increases in Blood Pressure and Major Adverse Cardiovascular Events in Patients With Renal Cell Carcinoma and Thyroid Cancer Treated With VEGFR TKIs. J Natl Compr Canc Netw Oct 2023.

Lee BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A. : Adult human cardiomyocyte mechanics in osteogenesis imperfecta. Am J Physiol Heart Circ Physiol Aug [epub ahead of print] 2023.

Jani V, Aslam MI, Fenwick AJ, Ma W, Gong H, Milburn G, Nissen D, Salazar IMC, Hanselman O, Mukherjee M, Halushka MK, Margulies KB, Campbell K, Irving TC, Kass DA, Hsu S: Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension. Circulation 147(25), Jun 2023.

Hahn VS, Petucci C, Kim MS, Bedi KC Jr, Wang H, Mishra S, Koleini N, Yoo EJ, Margulies KB, Arany Z, Kelly DP, Kass DA, Sharma K. : Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. Circulation 147(15), April 2023.

Saunders J, Sikder K, Phillips E, Ishwar A, Mothy D, Margulies KB, Choi JC: Limits Master Regulators That Govern Adipogenesis. Int J Mol Sci 24(7), March 2023.

Ramachandran A, Livingston CE, Vite A, Corbin EA, Bennett AI, Turner KT, Lee BW, Lam CK, Wu JC, Margulies KB. : Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload. J Cardiovasc Transl Res March 2023.

Ozcan M, Guo Z, Valenzuela Ripoll C, Diab A, Picataggi A, Rawnsley D, Lotfinaghsh A, Bergom C, Szymanski J, Hwang D, Asnani A, Kosiborod M, Zheng J, Hayashi RJ, Woodard PK, Kovacs A, Margulies KB, Schilling J, Razani B, Diwan A, Javaheri A: Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity. Cell Metab Feb. 2023.

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Last updated: 01/25/2024
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