Margaret M. Chou

Associate Professor of Pathology and Laboratory Medicine

Associate Professor, Children's Hospital of Philadelphia 1c Dept Path and Lab Medicine 7

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Department: Pathology and Laboratory Medicine

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46 Contact information
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3615 Civic Center Boulevard
36 ARC Bldg, 816E
Philadelphia, PA 19104-6058

2e Office: 267-426-9228
32 Fax: 267-426-5165
32 Lab: 267-426-9229
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Email:
mmc@pennmedicine.upenn.edu

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1f Graduate Group Affiliations 8

Pharmacology
Cell and Molecular Biology

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18 Publications
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26 Search PubMed for articles c

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13 Education:
21 9 B.A. 19 (Biochemistry) c
2d Barnard College (NY), 1987.
21 e Res. Asst 26 (Biochemistry/Cell Biology) c
34 Rockefeller University (NY), 1989.
21 a Ph.D. 1f (Molecular Oncology) c
2f Rockefeller University, 1993.
21 d Post-doc 19 (Cell Biology) c
34 Harvard Medical School (MA), 1997.
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Links
8e Search PubMed for articles
44 Cell and Molecular Biology graduate group faculty webpage.
3f Pharmacological Sciences graduate group faculty webpage.
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1f Post-Graduate Training
24 4a Research Assistant, Rockefeller University (Biochemistry/CellBiology) 1b , 1987-1989.
24 47 Post-doctoral Fellow, Harvard Medical School/Dept. of Cell Biology 1b , 1993-1977.
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3 3 90 Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

23 Research Interests
23 bone and soft tissue tumors
f sarcoma
2f mechanisms of malignant transformation
16 ubiquitination
f GTPases
d NFkB
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1f Description of Research
275 My career interest is to understand the mechanisms underlying malignant transformation. The progression of a normal cell into a cancerous one entails profound changes in numerous cellular functions, including its proliferation, survival, and motility/invasiveness, all of which contribute to metastatic behavior. These cell autonomous changes are coupled with alterations in the tumor cells’ microenvironment, which exhibits a mutual regulation with the tumor cells and impacts upon the above properties. My work has been aimed at identifying the signaling pathways that play pivotal roles in these processes.
445 Most recently, we have focused our efforts on elucidating critical pathogenic factors in the development of bone and soft tissue tumors (BSTTs). In comparison to carcinomas and hematological malignancies, much less is known about the etiology of BSTTs, some of which preferentially affect children. A subset of pediatric BSTTs are driven by pathognomonic chromosomal translocations, including Ewing sarcoma, alveolar rhabdomyosarcoma, and aneurysmal bone cyst. Studies in my laboratory are aimed at identifying the mechanisms by which they contribute in disease pathogenesis. We have recently determined that the TRE17/USP6 oncogene acts as a critical pathogenic agent across a number of BSTTs. TRE17 affects multiple aspects of tumor cell biology and simultaneously modulates the tumor microenvironment. The goals of my laboratory are to determine the molecular mechanisms by which TRE17 functions, to identify additional cellular pathways critical for BSTT pathogenesis, and to develop murine models of BSTTs to ultimately allow development of novel therapeutic strategies.
159 My laboratory also focuses on pathogenic mechanisms of Ewing sarcoma, alveolar rhabdomyosarcoma, and a newly described cancer, sinonasal sarcoma. Efforts are underway to identify the mechanism by which their respective pathognomonic translocations function in these cancers, and identifying novel sensitivities to cytotoxic agents.
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1e Lab personnel:
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29 Laura Quick (Research Specialist)
2a Robert Young (Research Specialist)
26 Ian Henrich (Graduate student)
2f Krista Bledsoe (Post-doctoral associate)
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Selected Publications

13f Pringle L M, Young R, Quick L, Riquelme D N, Oliveira A M, May M J, Chou M M: Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis. Oncogene 31(30): 3525-35, Jul 2012.

f5 Oliveira Andre M, Chou Margaret M: The TRE17/USP6 oncogene: a riddle wrapped in a mystery inside an enigma. Frontiers in bioscience (Scholar edition) 4: 321-34, Jan 1 2012.

1a2 Erickson-Johnson Michele R, Chou Margaret M, Evers Barbara R, Roth Christopher W, Seys Amber R, Jin Long, Ye Ying, Lau Alan W, Wang Xiaoke, Oliveira Andre M: Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Laboratory investigation; a journal of technical methods and pathology 91(10): 1427-33, Oct 2011.

170 Pietschmann Matthias F, Oliveira Andre M, Chou Margaret M, Ihrler Stefan, Niederhagen Manuel, Baur-Melnyk Andrea, Dürr Hans Roland: Aneurysmal bone cysts of soft tissue represent true neoplasms: a report of two cases. The Journal of bone and joint surgery. American volume 93(9): e45, May 2011.

1b9 Lau Alan W, Pringle Lashon M, Quick Laura, Riquelme Daisy N, Ye Ying, Oliveira Andre M, Chou Margaret M: TRE17/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. The Journal of biological chemistry 285(47): 37111-20, Nov 2010.

154 Ye Y, Pringle LM, Lau AW, Riquelme DN, Wang H, Jiang T, Lev D, Welman A, Blobel GA, Oliveira AM, Chou MM.: TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene In press, April 2010.

153 Blobel, G.A., Kadauke, S., Wang, E., Lau, A.W., Zuber, J., Chou, M.M., and Vakoc, C.R.: A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Molecular Cell 36(6): 970-983, December 2009.

145 Fellig, Y., Oliveira, A.M., Margolin, E., Gomori, J.M., Erickson-Johnson, M.R., Chou, M.M., Umansky, F., and Soffer, D.: Extraosseous aneurysmal bone cyst of cerebello-pontine angle with USP6 rearrangement. Acta Neuropathology 118: 579-581, Sept 2009.

10e Lau, AW and Chou, MM.: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway. Journal of Cell Science 121(24): 4008-4017, Nov 2008.

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26 Last updated: 07/11/2024
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