Kurt Allen Engleka

Adjunct Assistant Professor of Cell and Developmental Biology

Senior Research Investigator/Instructor B, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA

3 75

Department: Cell and Developmental Biology

4 1 b

46 Contact information
5e

Smilow Center for Translational Research, 09-187
4a 3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5157

2e Office: 215-898-0252
30

Email:
kengleka@mail.med.upenn.edu

4 3 3 3 2 4 b 1f

13 Education:
21 9 B.S. 14 (Biology) c
36 Pennsylvania State University, 1985.
21 a Ph.D. 19 (Biochemistry) c
35 George Washington University, 1992.
c

3 3 21

1f Post-Graduate Training
24 c0 Graduate Student/Research Technician, Molecular Biology, Laboratory of Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD, 1988-1992.
24 8f National Research Council Biotechnology Fellow, Laboratory of Molecular Growth Regulation/NICHD/NIH, Bethesda, MD, 1993-1996.
c

3 3 90 Permanent link
2 29

b6 > Perelman School of Medicine > Faculty > Details a

1e 1d

Description of Research Expertise

7c Over 25 years of successful protein biochemistry and cell biology experience in academic research studying:
8
7e Neural crest in development and disease with a focus on the transcription factor Pax3 and cardiovascular morphogenesis
8
46 Endothelial cell signaling mechanisms underlying angiogenesis
8
6f Fourteen years dedicated to managing laboratory of Jonathan A. Epstein, M.D., University of Pennsylvania
e 29

Selected Publications

f5 Ramjee, V., Li, D., Manderfield, L.J., Liu, F., Engleka, K.A., Aghajanian, H., Rodell, C.B., Lu, W., Ho, V., Wang, T., Li, L., Singh, A., Cibi, D.M., Burdick, J.A., Singh, M.K., Jain, R., Epstein, J.A. a3 : Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction. J. Clin. Invest. 127: 899-911, 2017.

16a Engleka, K.A. and Epstein, J.A.: Neural Crest Formation and Craniofacial Development. In Epstein’s Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis, Erickson, R.P. and Wynshaw-Boris, A.J., eds. (eds.). Oxford University Press, Page: 57-61, 2016.

9e Manderfield, L.J., Aghajanian, H., Engleka, K.A., Lim, L.Y., Liu, F., Jain, R., Li, L., Olson, E.N., Epstein, J.A. 2 a1 : Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest. Development 142: 2962-2971, 2015.

12c Yzaguirre, A.D., Padmanabhan, A., de Groh, E.D., Engleka, K.A., Li, J., Speck, N.A., Epstein, J.A.: Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Elife 4:e07780, 2015.

13f Manderfield, L.J., Engleka, K.A., Aghajanian, H., Gupta, M., Yang, S., Li, L., Baggs, J.E., Hogenesch, J.B., Olson, E.N., Epstein, J.A.: Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell Rep. 9: 1885-1895, 2014.

157 Engleka, K.A., Manderfield, L.J., Brust, R.D., Li, L., Cohen, A., Dymecki, S.M., Epstein, J.A.: Islet1 derivatives in the heart are of both neural crest and second heart field origin. Cir Res. 110(7): 922-6, Mar 2012 Notes: Erratum in: Circ Res. 2012 May 25;110(11):e90.

114 Manderfield, L.J., High, F.A., Engleka, K.A., Liu, F, Li, L., Rentschler, S., Epstein, J.A.: Notch activation of Jagged1 contributes to the assembly of the arterial wall Circulation 125: 314-323, 2012.

12e Jain, R., Engleka, K.A., Rentschler, S.L., Manderfield, L.J., Li, L., Yuan, L., Epstein, J.A.: Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. J. Clin. Invest. 121: 422-430, 2011.

17f Degenhardt, K.R., Milewski, R.C., Padmanabhan, A., Miller, M., Singh, M.K., Lang, D., Engleka, K.A, Wu, M., Li, J., Zhou, D., Antonucci, N., Li, L., Epstein, J.A.: Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev. Biol. 339: 519-527, 2010.

a3 Griffith, A.V., Cardenas, K., Carter, C., Gordon, J., Iberg, A., Engleka, K., Epstein, .JA., Manley, N.R., Richie, E.R. 99 : Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Dev. Biol. 327: 216-27, 2009.

2c

7 1d

2c back to top
26 Last updated: 06/12/2017
34 The Trustees of the University of Pennsylvania c