Matthew Tudor

Adjunct Assistant Professor of Cell and Developmental Biology

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Department: Cell and Developmental Biology

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46 Contact information
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Screening & Protein Sciences
29 Merck Research Laboratories, NW-1
32 502 Louise Lane
North Wales, PA 19454

2f Office: 267-305-1517
32 Fax: 267-305-3625
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13 Education:
21 9 B.S. 21 (Biology, With Honors) c
2b Cornell University, 1995.
21 a Ph.D. 3b (Biology (Advisors: Rudolf Jaenish, Rick Young)) c
3e Massachusetts Institute of Technology, 2004.
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Links
60 Adjunct Assistant Professor
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1f Post-Graduate Training
24 8f Presidential Postdoctoral Fellow, Novartis Institutes for Biomedical Research, Cambridge MA (Advisor, Rick Young), 2005-2007.
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3 3 92 Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

17d High throughput liquid handling and cell-based assay technologies, laboratory automation, small molecule and genetic screening, high content assay development and analysis, high throughput expression profiling, combinatorial screening, flow cytometry, microscopy, molecular biology, biochemistry, transgenic mouse generation and phenotyping, microarray technologies
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Selected Publications

13b Coyne, C.B., Bozym, R., Morosky, S.A., Hanna, S.L., Mukherjee, A., Tudor, M., Kim, K.S., Cherry S.: RNAi screening reveals host factors involved in enteroviruses infection of polarized endothelial monolayers. Cell Host Microbe 9: 70-82, 2010.

11c Tudor, M., Akbarian, S., Chen, R. Z. & Jaenisch, R.: Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A 99: 15536-41, 2002.

153 Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., and Jaenisch, R.: Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet 27: 31-9, 2001.

10e Chen, Z.H., Akbarian, S., Tudor, M., Jaenisch, R.: Deficiency of methyl-CpG binding protein 2 (MeCP2) in CNS neurons results in a Rett-like phenotype in mice, Nat Genet Nat Genet 27: 327-31, 2001.

12a Wilson C.J., Guglielmo C., Moua N.D., Tudor M., Grosveld G., Young R.A., Murray P.J: Yeast artificial chromosome targeting technology: an approach for the deletion of genes in the C57BL/6 mouse. Anal Biochem 296: 270-8, 2001.

135 Lyko, F., Ramsahoye, B. H., Kashevsky, H., Tudor, M., Mastrangelo, M. A., Orr-Weaver, T. L., and Jaenisch, R.: Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nat Gen 23: 363-6, 1999.

113 Tudor, M., Murray, P. J., Onufryk, C., Jaenisch, R., and Young, R. A.: Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev 13: 2365-8, 1999.

193 Takenaka, T., Hendrickson, C. S., Tworek, D. M., Tudor, M., Schiffmann, R., Brady, R. O., and Medin, J. A.: Enzymatic and functional correction along with long-term enzyme secretion from transduced bone marrow hematopoietic stem/progenitor and stromal cells derived from patients with Fabry disease. Exp Hematol 27: 1149-59, 1999.

fd Fan H.Y., Hu Y., Tudor M., Ma H.: Specific interactions between the K domains of AG and AGLs, members of the MADS domain family of DNA binding proteins. Plant J 12: 999-1010, 1997.

189 Medin, J. A., Tudor, M., Simovitch, R., Quirk, J. M., Jacobson, S., Murray, G. J., and Brady, R. O: Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high- titer recombinant retroviral vector. Proc Natl Acad Sci U S A 93: 7917-22, 1996.

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