Nicolas Daniel Plachta

faculty photo
William Richard Gordon President's Distinguished Professor in Genetics
Department: Cell and Developmental Biology

Contact information
3400 Civic Center Boulevard
Smilow Center for Translational Research
Office 9-123
Philadelphia, PA 19104
Office: 215-573-7462
Lab: 215-746-4313
Education:
BSc (Biology)
University of Tel-Aviv, Israel, 2003.
Ph.D. (Neurobiology)
University of Basel, Switzerland, 2007.
Post-Graduate Training
Postdoctoral Fellow, Swiss National Science Foundation, Switzerland, 2007-2008.
Postdoctoral Fellow, European Molecular Biology Organization (EMBO) , 2008-2009.
Postdoctoral Researcher, California Institute of Technology (Caltech) Pasadena, CA, 2008-2011.
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Description of Research Expertise

Research Interests
The Plachta lab uses live imaging technologies to study how the early mammalian embryo forms. Our goal is to reveal how cells choose their fate, shape and position in real time and in vivo to form a living mammalian organism.

Key words: Live imaging, mammalian development, single-cell biology, morphogenesis

Selected Publications

Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N: Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature (London). Nature Publishing Group, 585(7825): 404-409, September 2020.

Zenker J, White M, Gasnier M, Alvarez Y, Lim G, Bissiere S, Biro M, Plachta N: Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation. Cell 173(3): 776-791.e17, 04 2018.

Zenker J, White M, Templin R, Parton R, Thorn-Seshold O, Bissiere S, Plachta N: A microtubule-organizing center directing intracellular transport in the early mouse embryo. Science American Association for the Advancement of Science, 357(6354): 925-928, 09 2017.

White M, Angiolini J, Alvarez Y, Kaur G, Zhao Z, Mocskos E, Bruno L, Bissiere S, Levi V, Plachta N: Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo. Cell. Elsevier Inc, 165(1): 75-87, Mar 2016.

Samarage C, White M, Álvarez Y, Fierro-González J, Henon Y, Jesudason E, Bissiere S, Fouras A, Plachta N: Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo. Developmental cell 34(4): 435-47, Aug 2015.

Fierro-González J, White M, Silva J, Plachta N: Cadherin-dependent filopodia control preimplantation embryo compaction. Nature cell biology. Nature Publishing Group, 15(12): 1424-33, Dec 2013.

Kaur G, Costa M, Nefzger C, Silva J, Fierro-González J, Polo J, Bell T, Plachta N: Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy. Nature communications 4: 1637, 2013.

Plachta N, Bollenbach T, Pease S, Fraser S, Pantazis P: Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nature cell biology. Nature Publishing Group, 13(2): 117-23, Feb 2011.

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Last updated: 02/22/2021
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