Kyla Ortved

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

382 W. Street Road
Kennett Square, PA 19348

Office: 610-925-6195
Lab: 610-925-6255

Email:
kortved@vet.upenn.edu

Publications

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Links
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Education:
B.Sc. (Animal Biology)
University of British Columbia, 2001.
DVM (Veterinary Medicine)
University of Guelph, 2006.
PhD (Comparative Biomedical Sciences)
Cornell University, 2014.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Equine orthopedic surgery
Fracture repair
Arthroscopy
Tenoscopy
Regenerative medicine

Description of Research Expertise

Establishing regenerative therapies to improve musculoskeletal healing using the horse as a model for human disease. Specifically, my research program is targeted towards developing gene and cell therapies to improve cartilage repair and prevent osteoarthritis; establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects; elucidating the pathophysiology of posttraumatic osteoarthritis; and adeno-associated virus mediated overexpression of immunomodulatory cytokines in the joint.

Selected Publications

Chapman HS, Gale AL, Dodson ME, Linardi RL, Ortved KF: The effect of autologous platelet lysate on the differentiation potential of equine bone marrow-derived mesenchymal stem cells. Stem Cells Dev 29: 144-155, 2020.

Brown KA, Davidson EJ, Johnson A, Wulster KB, Ortved KF: Assessment of intra-synovial inflammatory cytokines in horses with standing cone bean computed tomographic evidence of cervical articular process joint osteoarthritis. EVJ 49: 590-599, 2021.

Boorman S, Hofmeister EH, Ross MW, Ralston S, Bell S, Mackie S, Ortved KF: Osteochondrosis decreases the longevity and racing performance of Standardbred trotters and pacers. Vet Surg 2021.

Farnham M, Ortved KF, Homer JS, Wagner NJ, Burris DL, Price C: Lubricant effects on articular cartilage sliding biomechanics under physiological fluid load support. Tribology Letters 2021.

Farnham M, Ortved KF, Burris DL, Price C: Articular cartilage friction, strain, and viability under physiological to pathological benchtop sliding conditions. Cellular and Molecular Bioengineering 2021.

Connard SS, Linardi RL, Even KM, Berglund AK, Schnabel LV, Ortved KF: Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro. Vet Immunol Immunopathol 2021.

Cameron AD, Even KM, Linardi RL, Berglund AK, Schnabel LV, Engiles JE: Investigation of the effects of AAV-mediated overexpression of IL-10 on the immunomodulatory properties of equine BM-MSCs. Human Gene Therapy. Human Gene Therapy 2021.

Gaesser AM, Underwood C, Linardi RL, Even KM, Reef VB, Shetye SS, Mauck RL, King WJ, Engiles JE, Ortved KF: Evaluation of autologous protein solution injection for treatment of superficial digital flexor tendonitis in an equine model. Frontiers Vet Sci 8:a697551, 2021.

Cianci JM, Wulster KB, Richardson DW, Stefanovski D, Ortved KF: Computed tomographic assessment of fracture characteristics and subchondral bone injury in Thoroughbred racehorses with lateral condylar fractures and their relationship to outcome. Vet Surg 51: 426-437, 2022.

Redding LE, Elzer EJ, Ortved KF: Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: a meta-analysis. PLoS One 17:e0265971, 2022.

Even KM, Gaesser AM, Ciamillo SA, Linardi RL, Ortved KF: Comparing the immunomodulatory properties of equine BM-MSCs culture expanded in autologous platelet lysate, pooled platelet lysate, equine serum and fetal bovine serum supplemented culture media. Frontiers Vet Sci 9:958724, 2022.

Ciamillo SA, Pownder SL, Potter HG, Stefanovski D, Nixon AJ, Ortved KF. : Correlation of magnetic resonance imaging (MRI) and optical coherence tomography (OCT) with healing of cartilage defects implanted with chondrocytes overexpressing IGF-I. online ahead of print 2023.