Veronique M Lefebvre

Professor of Orthopaedic Surgery

Department: Orthopaedic Surgery

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Translational Program in Pediatric Orthopaedics
Department of Surgery/Division of Orthopaedic Surgery
Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson Research Building, 907a
Philadelphia, PA 19104

Office: 215-590-0146

Email:
LEFEBVREV1@EMAIL.CHOP.EDU

Education:
B.S. (Zoology, Molecular Genetics)
Université Catholique de Louvain, Belgium, 1982.
Ph.D. (Cell Biology, Biochemistry)
Université Catholique de Louvain, Belgium, 1990.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Angelozzi M, Pellegrino da Silva R, Gonzalez MV, Lefebvre V.: Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors. Cell Rep 40: 111045, Jul 2022.

Li L, Medina-Menéndez C, García-Corzo L, Córdoba-Beldad CM, Quiroga AC, Calleja Barca E, Zinchuk V, Muñoz-López S, Rodríguez-Martín P, Ciorraga M, Colmena I, Fernández S, Vicario C, Nicolis SK, Lefebvre V, Mira H, Morales AV.: SoxD genes are required for adult neural stem cell activation. Cell Rep 38: 110313, Feb 2022.

Mino N, Muro R, Ota A, Nitta S, Lefebvre V, Nitta T, Fujio K, Takayanagi H.: The transcription factor Sox4 is required for thymic tuft cell development. Int Immunol 34: 45-52, Jan 2022.

Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K.: Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis. Nat Immunol 2022.

Angelozzi M, Karvande A, Molin AN, Ritter AL, Leonard JMM, Savatt JM, Douglass K, Myers SM, Grippa M, Tolchin D, Zackai E, Donoghue S, Hurst ACE, Descartes M, Smith K, Velasco D, Schmanski A, Crunk A, Tokita MJ, de Lange IM, van Gassen K, Robinson H, Guegan K, Suri M, Patel C, Bournez M, Faivre L, Tran-Mau-Them F, Baker J, Fabie N, Weaver K, Shillington A, Hopkin RJ, Barge-Schaapveld DQCM, Ruivenkamp CA, Bökenkamp R, Vergano S, Seco Moro MN, Díaz de Bustamante A, Misra VK, Kennelly K, Rogers C, Friedman J, Wigby KM, Lenberg J, Graziano C, Ahrens-Nicklas RC, Lefebvre V.: Consolidation of the clinical and genetic definition of a SOX4-related neurodevelopmental syndrome. J Med Genet 2022.

Chory J, Olson EN, Solnica-Krezel L, Munro S, Fuchs E, St Johnston D, Lefebvre V, Coupland G, Millar SE, Lin H.: 20 years of Developmental Cell: Looking back. Dev Cell 56: 3181-3184, Dec 2021.

Nunomura S, Nanri Y, Lefebvre V, Izuhara K.: Epithelial SOX11 regulates eyelid closure during embryonic eye development. Biochem Biophys Res Commun 549: 27-33, Apr 2021.

Haseeb A, Kc R, Angelozzi M, de Charleroy C, Rux D, Tower RJ, Yao L, Pellegrino da Silva R, Pacifici M, Qin L, Lefebvre V.: SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation. Proc Natl Acad Sci U S A 118: e2019152118, Feb 2021.

Jones K, Angelozzi M, Gangishetti U, Haseeb A, de Charleroy C, Lefebvre V, Bhattaram P.: Human Adult Fibroblast-like Synoviocytes and Articular Chondrocytes Exhibit Prominent Overlap in Their Transcriptomic Signatures. ACR Open Rheumatol 2021.

de Charleroy C, Haseeb A, Lefebvre V.: Preparation of Adult Mouse Skeletal Tissue Sections for RNA In Situ Hybridization. Methods Mol Biol 2021.