Ning Li
Research Assistant Professor, Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine
Contact information
Department of Biomedical Sciences
School of Veterinary Medicine
University of Pennsylvania
418 Hill Pavilion
380 S. University Avenue
Philadelphia, PA 19104
School of Veterinary Medicine
University of Pennsylvania
418 Hill Pavilion
380 S. University Avenue
Philadelphia, PA 19104
Office: 215-746-7055
Email:
ningli@upenn.edu
ningli@upenn.edu
Publications
Education:
MD (Medicine)
Taishan Medical College, 2002.
Permanent linkMD (Medicine)
Taishan Medical College, 2002.
Description of Research Expertise
Mechanisms of colorectal cancer initiation and progression; Intratumoral heterogeneity and mechanisms of multi drug resistance, Role of epithelial-mesenchymal interactions during colorectal cancer development, Generation of engineered mouse models of colorectal cancer, In vivo single cell transcriptomic approaches.Selected Publications
Sela, Y., Li, J., Kuri, P., Merrell, A. J., Li, N., Lengner, C., Rompolas, P., Stanger, B. Z.: Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation. Elife 10, 2021.Kumar, S., Nandi, A., Singh, S., Regulapati, R., Li, N., Tobias, J. W., Siebel, C. W., Blanco, M. A., Klein-Szanto, A. J., Lengner, C., Welm, A. L., Kang, Y., Chakrabarti, R.: Dll1(+) quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun 12(1): 432, 2021.
Kolev, H. M., Tian, Y., Kim, M. S., Leu, N. A., Adams-Tzivelekidis, S., Lengner, C. J., Li, N., Kaestner, K. H.: A FoxL1-CreERT-2A-tdTomato mouse labels subepithelial telocytes. Cellular and Molecular Gastroenterology and Hepatology 12(3): 1155-1158.e4, 2021.
Efimova, N., Yang, C., Chia, J. X., Li, N., Lengner, C. J., Neufeld, K. L., Svitkina, T. M.: Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion. Journal of Cell Biology 219(9), 2020.
Tang, A. T., Sullivan, K. R., Hong, C. C., Goddard, L. M., Mahadevan, A., Ren, A., Pardo, H., Peiper, A., Griffin, E., Tanes, C., Mattei, L. M., Yang, J., Li, L., Mericko-Ishizuka, P., Shen, L., Hobson, N., Girard, R., Lightle, R., Moore, T., Shenkar, R., Polster, S. P., Roedel, C. J., Li, N., Zhu, Q., Whitehead, K. J., Zheng, X., Akers, A., Morrison, L., Kim, H., Bittinger, K., Lengner, C. J., Schwaninger, M., Velcich, A., Augenlicht, L., Abdelilah-Seyfried, S., Min, W., Marchuk, D. A., Awad, I. A., Kahn, M. L.: Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Science Translational Medicine 11(520), 2019.
Yousefi, M., Nakauka-Ddamba, A., Berry, C. T., Li, N., Schoenberger, J., Simeonov, K. P., Cedeno, R. J., Yu, Z., Lengner, C. J.: Calorie restriction governs intestinal epithelial regeneration through cell-autonomous regulation of mTORC1 in reserve stem cells. Stem Cell Reports 10(3): 703-711, 2018.
Cedeno, R. J., Nakauka-Ddamba, A., Yousefi, M., Sterling, S., Leu, N. A., Li, N., Pehrson, J. R., Lengner, C. J.: The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment. PloS One 12(9): e0185196, 2017.
Yousefi, M., Li, N., Nakauka-Ddamba, A., Wang, S., Davidow, K., Schoenberger, J., Yu, Z., Jensen, S. T., Kharas, M. G., Lengner, C. J.: Msi RNA-binding proteins control reserve intestinal stem cell quiescence. Journal of Cell Biology 215(3): 401-413, 2016.
Li, N., Yousefi, M., Nakauka-Ddamba, A., Tobias, J. W., Jensen, S. T., Morrisey, E. E., Lengner, C. J.: Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts. Developmental Dynamics 245(8): 822-33, 2016.
Li, N., Nakauka-Ddamba, A., Tobias, J., Jensen, S. T., Lengner, C. J.: Mouse label-retaining cells are molecularly and functionally distinct from reserve intestinal stem cells. Gastroenterology 151(2): 298-310.e7, 2016.
Katlinskaya, Y. V., Katlinski, K. V., Lasri, A., Li, N., Beiting, D. P., Durham, A. C., Yang, T., Pikarsky, E., Lengner, C. J., Johnson, F. B., Ben-Neriah, Y., Fuchs, S. Y.: Type I interferons control proliferation and function of the intestinal epithelium. Molecular and Cellular Biology 36(7): 1124-35, 2016.
Yu, Q., Katlinskaya, Y. V., Carbone, C. J., Zhao, B., Katlinski, K. V., Zheng, H., Guha, M., Li, N., Chen, Q., Yang, T., Lengner, C. J., Greenberg, R. A., Johnson, F. B., Fuchs, S. Y.: DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function. Cell Reports 11(5): 785-797, 2015.
Wang, S., Li, N., Yousefi, M., Nakauka-Ddamba, A., Li, F., Parada, K., Rao, S., Minuesa, G., Katz, Y., Gregory, B. D., Kharas, M. G., Yu, Z., Lengner, C. J.: Transformation of the intestinal epithelium by the MSI2 RNA-binding protein. Nat Commun 6: 6517, 2015.
Li, N., Yousefi, M., Nakauka-Ddamba, A., Li, F., Vandivier, L., Parada, K., Woo, D. H., Wang, S., Naqvi, A. S., Rao, S., Tobias, J., Cedeno, R. J., Minuesa, G., Y, K., Barlowe, T. S., Valvezan, A., Shankar, S., Deering, R. P., Klein, P. S., Jensen, S. T., Kharas, M. G., Gregory, B. D., Yu, Z., Lengner, C. J.: The Msi Family of RNA-binding proteins function redundantly as intestinal oncoproteins. Cell Reports 13(11): 2440-2455, 2015.