Selected Publications

Aguirre, G. D., Cideciyan, A. V., Dufour, V. L., Ripolles-Garcia, A., Sudharsan, R., Swider, M., Nikonov, R., Iwabe, S., Boye, S. L., Hauswirth, W. W., Jacobson, S. G., Beltran, W. A.: Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis. Mol. Ther. 29(8): 2456-2468, 2021.

Sudharsan, R., Murgiano, L., Tang, H. Y., Olsen, T. W., Chavali, V. R. M., Aguirre, G. D., Beltran, W. A.: Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration. Sci Rep. 11(1): 460, 2021.

Badiei, A., Sudharsan, R., Santana, E., Dunaief, J. L., Aguirre, G. D.: Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. Exp. Eye Res. 181: 72-84, 2019.

Sudharsan, R., Beltran, W. A.: Progress in Gene Therapy for Rhodopsin Autosomal Dominant Retinitis Pigmentosa. Adv. Exp. Med. Biol. 1185: 113-118, 2019.

Cideciyan, A. V., Sudharsan, R., Dufour, V. L., Massengill, M. T., Iwabe, S., Swider, M., Lisi, B., Sumaroka, A., Marinho, L. F., Appelbaum, T., Rossmiller, B., Hauswirth, W. W., Jacobson, S. G., Lewin, A. S., Aguirre, G. D., Beltran, W. A.: Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proc. Natl. Acad. Sci. U.S.A. 115(36): E8547-E8556, 2018.

Sudharsan, Raghavi, Elliott, Michael H, Dolgova, Natalia, Aguirre, Gustavo D, Beltran, William A: Photoreceptor outer segment isolation from a single canine retina for RPE phagocytosis assay. Adv. Exp. Med. Biol. 1074: 593-601, 2018.

Sudharsan, R., Beiting, D. P., Aguirre, G. D., Beltran, W. A.: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration. Sci. Rep. 7(1): 17897, 2017.

Sudharsan, R., Simone, K. M., Anderson, N. P., Aguirre, G. D., Beltran, W. A.: Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 58(1): 270-281, 2017.

Marsili, S., Genini, S., Sudharsan, R., Gingrich, J., Aguirre, G. D., Beltran, W. A.: Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One 10(2): e0115723, 2015.

Sudharsan, R., Azuma, Y.: The SUMO ligase PIAS1 regulates UV-induced apoptosis by recruiting Daxx to SUMOylated foci. J Cell Sci. 125(Pt 23): 5819-29, 2012.

Stensrud, K. F., Adam, P. R., La Mar, C. D., Olive, A. J., Lushington, G. H., Sudharsan, R., Shelton, N. L., Givens, R. S., Picking, W. L., Picking, W. D.: Deoxycholate interacts with IpaD of Shigella flexneri in inducing the recruitment of IpaB to the type III secretion apparatus needle tip. J. Biol. Chem. 283(27): 18646-54, 2008.