Leah Makaron
Assistant Professor of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Publications
Education:
DVM (Veterinary Medicine)
Ross University School of Veterinary Medicine, 2009.
Permanent linkDVM (Veterinary Medicine)
Ross University School of Veterinary Medicine, 2009.
Description of Clinical Expertise
Experience with various animal models utilized in biomedical research with a focus on non-human primate medicine, anesthesia and surgery. Interest in integrative medicine including acupuncture and TCVM. Regulatory oversight including protocol review, assisting labs with model development and protocol writing, collaborating with the Office of Animal Welfare on issues related to compliance, and the development of guidelines and policies governing the humane care of research animals at Penn.Description of Research Expertise
Neuroscience - Aging, memory and cognition; enrichment and behavior of animals in biomedical research environments; veterinary acupuncture; advocacy in research animal medicineSelected Publications
Wilson, J. M., Wallace, C. K., Brice, A. K., Makaron, L.: Mineralized trichobezoars in a rhesus macaque (Macaca mulatta). Journal of Medical Primatology 49(3): 158-161, 2020.Lyubarsky, A., Wielechowski, E., Aleman, T. S., Maguire, A. M., Ying, G. S., Bote, E., Makaron, L., Morgan, J. I. W., Tretiakova, A., Wilson, J., Bennett, J.: Safety of subretinal delivery of RGX-314 (AAV8-anti-VEGF Fab) in the non-human primate as assessed by full-field ERG. Investigative Ophthalmology & Visual Science 59(9), 2018.
Wang, L. L., Wilson, J. M., Calcedo, R., Bell, P., He, Z. N., White, J., Hewitt, M., Makaron, L., Kattenhorn, L., Wadsworth, S., Goode, T.: Strategies for selection of AAV Vectors for administration to liver: studies in nonhuman primates. Blood 128(22), 2016.
Greig, J. A., Nordin, J. M., Bote, E., Makaron, L., Garnett, M. E., Kattenhorn, L. M., Bell, P., Goode, T., Wilson, J. M.: Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques. Mol Ther Methods Clin Dev 3: 16079, Dec 2016.
Kramer, J. A., Grindley, J., Crowell, A. M., Makaron, L., Kohli, R., Kirby, M., Mansfield, K. G., Wachtman, L. M.: The common marmoset as a model for the study of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Veterinary Pathology 52(2): 404-13, 2015.
Makaron, L., Moran, C. A., Namjoshi, O., Rallapalli, S., Cook, J. M., Rowlett, J. K.: Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys. Pharmacol Biochem Behav 104: 62-8, 2013.
Makaron, L., Smith, K., Bailey, C., Kaliyaperumal, S., Miller, A., Kramer, J.: Immune-mediated interface dermatitis in a rhesus macaque. Journal of Medical Primatology 41(5): 332-5, 2012.
Shamy, J. L., Buonocore, M. H., Makaron, L. M., Amaral, D. G., Barnes, C. A., Rapp, P. R.: Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta). Neurobiology of Aging 27(10): 1405-15, 2006.