Charles-Antoine Assenmacher
Technical Director of the Comparative Pathology Core, University of Pennsylvania, School of Veterinary Medicine
Assistant Professor of Comparative Pathology, University of Pennsylvania School of Veterinary Medicine
Publications
Education:
DVM
University of Liège, School of Veterinary Medicine, Liège, Belgium, 2012.
Permanent linkDVM
University of Liège, School of Veterinary Medicine, Liège, Belgium, 2012.
Description of Research Expertise
My main research interest is the pathological evaluation of laboratory animals used in fundamental research and preclinical studies. A major focus of this research is the assessment of effects and toxicities of immunotherapies and genetic engineering. I am also passionate about developing the field of image analysis on digital slides for data quantification and analysis. Diagnostically, I have a strong interest in ocular pathology and oversee the ocular pathology service within the Penn Vet Diagnostic Laboratory.Selected Publications
Bertram, C. A., Aubreville, M., Donovan, T. A., Bartel, A., Wilm, F., Marzahl, C., Assenmacher, C. A., Becker, K., Bennett, M., Corner, S., Cossic, B., Denk, D., Dettwiler, M., Gonzalez, B. G., Gurtner, C., Haverkamp, A. K., Heier, A., Lehmbecker, A., Merz, S., Noland, E. L., Plog, S., Schmidt, A., Sebastian, F., Sledge, D. G., Smedley, R. C., Tecilla, M., Thaiwong, T., Fuchs-Baumgartinger, A., Meuten, D. J., Breininger, K., Kiupel, M., Maier, A., Klopfleisch, R.: Computer-assisted mitotic count using a deep learning-based algorithm improves interobserver reproducibility and accuracy. Veterinary Pathology 59(2): 211-226, 2022.Sultan, L. R., Cary, T. W., Al-Hasani, M., Karmacharya, M. B., Venkatesh, S. S., Assenmacher, C. A., Radaelli, E., Sehgal, C. M.: Can Sequential Images from the Same Object Be Used for Training Machine Learning Models? A Case Study for Detecting Liver Disease by Ultrasound Radiomics. AI (Basel) 3(3): 739-750, 2022.
Lenz, J. A., Assenmacher, C. A., Costa, V., Louka, K., Rau, S., Keuler, N. S., Zhang, P. J., Maki, R. G., Durham, A. C., Radaelli, E., Atherton, M. J.: Increased tumor-infiltrating lymphocyte density is associated with favorable outcomes in a comparative study of canine histiocytic sarcoma. Cancer Immunology, Immunotherapy 71(4): 807-818, 2022.
Assenmacher, C. A., Santagostino, S. F., Oyama, M. A., Marine, J. C., Bonvin, E., Radaelli, E.: Classification and Grading of Melanocytic Lesions in a Mouse Model of NRAS-driven Melanomagenesis. Journal of Histochemistry and Cytochemistry 69(3): 203-218, 2021.
Zhang, Q., Hresko, M. E., Picton, L. K., Su, L., Hollander, M. J., Nunez-Cruz, S., Zhang, Z., Assenmacher, C. A., Sockolosky, J. T., Garcia, K. C., Milone, M. C.: A human orthogonal IL-2 and IL-2Rbeta system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia. Science Translational Medicine 13(625): eabg6986, 2021.
Velalopoulou, A., Karagounis, I. V., Cramer, G. M., Kim, M. M., Skoufos, G., Goia, D., Hagan, S., Verginadis,, II, Shoniyozov, K., Chiango, J., Cerullo, M., Varner, K., Yao, L., Qin, L., Hatzigeorgiou, A. G., Minn, A. J., Putt, M., Lanza, M., Assenmacher, C. A., Radaelli, E., Huck, J., Diffenderfer, E., Dong, L., Metz, J., Koumenis, C., Cengel, K. A., Maity, A., Busch, T. M.: FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response. Cancer Research 81(18): 4808-4821, 2021.
Tarrant, J. C., Binder, Z. A., Bugatti, M., Vermi, W., van den Oord, J., Ranieri, B., Assenmacher, C. A., Hoepp, N., O'Rourke, D. M., Shan, X., Danet-Desnoyers, G., Radaelli, E.: Pathology of macrophage activation syndrome in humanized NSGS mice. Research in Veterinary Science 134: 137-146, 2021.
Santagostino, S. F., Assenmacher, C. A., Tarrant, J. C., Adedeji, A. O., Radaelli, E.: Mechanisms of Regulated Cell Death: Current Perspectives. Veterinary Pathology 58(4): 596-623, 2021.
Nguyen, G. N., Everett, J. K., Kafle, S., Roche, A. M., Raymond, H. E., Leiby, J., Wood, C., Assenmacher, C. A., Merricks, E. P., Long, C. T., Kazazian, H. H., Nichols, T. C., Bushman, F. D., Sabatino, D. E.: A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells. Nature Biotechnology 39(1): 47-55, 2021.
Church, M. E., Ceja, G., McGeehan, M., Miller, M. C., Farias, P., Sanchez, M. D., Swain, G. P., Assenmacher, C. A., Stopa, E. G., Vite, C. H., Bar-Or, A., Alvarez, J. I.: Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis. Journal of Immunology 207(1): 44-54, 2021.
Chen, K. W., Demarco, B., Ramos, S., Heilig, R., Goris, M., Grayczyk, J. P., Assenmacher, C. A., Radaelli, E., Joannas, L. D., Henao-Mejia, J., Tacchini-Cottier, F., Brodsky, I. E., Broz, P.: RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. Proceedings of the National Academy of Sciences of the United States of America 118(28), 2021.
Breda, L., Ghiaccio, V., Tanaka, N., Jarocha, D., Ikawa, Y., Abdulmalik, O., Dong, A., Casu, C., Raabe, T. D., Shan, X., Danet-Desnoyers, G. A., Doto, A. M., Everett, J., Bushman, F. D., Radaelli, E., Assenmacher, C. A., Tarrant, J. C., Hoepp, N., Kurita, R., Nakamura, Y., Guzikowski, V., Smith-Whitley, K., Kwiatkowski, J. L., Rivella, S.: Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Molecular Therapy 29(4): 1625-1638, 2021.
Aghajanian, H., Kimura, T., Rurik, J. G., Hancock, A. S., Leibowitz, M. S., Li, L., Scholler, J., Monslow, J., Lo, A., Han, W., Wang, T., Bedi, K., Morley, M. P., Linares Saldana, R. A., Bolar, N. A., McDaid, K., Assenmacher, C. A., Smith, C. L., Wirth, D., June, C. H., Margulies, K. B., Jain, R., Pure, E., Albelda, S. M., Epstein, J. A.: Targeting cardiac fibrosis with engineered T cells. Nature 573(7774): 430-433, 2019.