Andrew Meltzer Hoffman
Gilbert S. Kahn Dean of Veterinary Medicine, University of Pennsylvania School of Veterinary Medicine
Professor, Large Animal Medicine, University of Pennsylvania School of Veterinary Medicine
Publications
Education:
DVM (Veterinary Medicine)
Cornell University College of Veterinary Medicine, 1985.
DVSc (Pharmacology)
University of Guelph, Ontario, 1990.
Permanent linkDVM (Veterinary Medicine)
Cornell University College of Veterinary Medicine, 1985.
DVSc (Pharmacology)
University of Guelph, Ontario, 1990.
Description of Clinical Expertise
Clinical interests incllude:* Pulmonary Physiology
* Cellular and Molecular Biology
* Regenerative Medicine
Contributions include (1) novel studies into the pathophysiology of equine asthma, (2) development of rigorous methods of assessing pulmonary function in animals, (3) development of novel non-surgical treatments for human emphysema, (4) elucidation of molecular mechanisms controlling lung regeneration, and (5) development of companion animal disease models, specifically for advancement of research into roles for extracellular vesicles in disease pathogenesis and therapeutic factors.
Description of Research Expertise
Dr. Hoffman has extensive experience, publications (~100), and patents (4) concerning novel methods of evaluation or therapies in spontaneous and experimental disease models in large animals. He also has ~15 yrs experience specifically in the development of preclinical large animal models in accordance with Good Laboratory Practices (GLP), including as PI/PD in a current study funded by NIH (RO1-HL112987-01A1) “Autologous Lung Derived Mesenchymal Stromal Cell Therapy for Emphysema”. Importantly this active study includes GLP-like pre-clinical studies in a large animal (sheep) model of emphysema followed by the first-in-human Phase 1 investigation of autologous LMSCs therapy for advanced emphysema in years 4-5, the latter under the direction of Edward P. Ingenito MD, PhD (PD/PI, Brigham and Womens Hospital).Previously Drs. Hoffman and Ingenito developed major advances in human emphysema therapy, specifically non-surgical methods for lung volume reduction which are currently in Phase III again successfully linking pre-clinical large animal models with human studies. In addition, Dr. Hoffman’s laboratory serves as a Regenerative Medicine / Stem Cell core and project leader on several studies involving canine, feline, and avian species funded by a variety of Foundations and industry partners.
These multifaceted experiences have given the PD/PI the experience to lead multi-disciplinary projects involving stem cell implantations, bioengineering technologies, large animal experimental or spontaneous models, cell-molecular biology, biomarker analyses, clinical trial design, and FDA (GLP, GCP, GMP) compliance.
Selected Publications
Borel, F., Sun, H., Zieger, M., Cox, A., Cardozo, B., Li, W., Oliveira, G., Davis, A., Gruntman, A., Flotte, T. R., Brodsky, M. H., Hoffman, A. M., Elmallah, M. K., Mueller, C.: Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. Proc Natl Acad Sci U S A 115(11): 2788-2793, 2018.Yang, V. K., Tai, A. K., Huh, T. P., Meola, D. M., Juhr, C. M., Robinson, N. A., Hoffman, A. M.: Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease. PLoS One 13(1): e0188617, 2018.
Davis, A. M., Thane, K. E., Hoffman, A. M.: Practical methods for assessing emphysema severity based on estimation of linear mean intercept (lm) in the context of animal models of alpha-1 antitrypsin deficiency. Methods Mol Biol 1639: 93-106, 2017.
Yang, V. K., Loughran, K. A., Meola, D. M., Juhr, C. M., Thane, K. E., Davis, A. M., Hoffman, A. M.: Circulating exosome microRNA associated with heart failure secondary to myxomatous mitral valve disease in a naturally occurring canine model. J Extracell Vesicles 6(1): 1350088, 2017.
Wichtel M, Gomez D, Burton S, Wichtel J, Hoffman AM.: Relationships between equine airway reactivity measured by flowmetric plethysmography and specific indicators of airway inflammation in horses with suspected inflammatory airway disease. Equine Vet J 48(4): 466-71, July 2016.
Platz, J., Bonenfant, N. R., Uhl, F. E., Coffey, A. L., McKnight, T., Parsons, C., Sokocevic, D., Borg, Z. D., Lam, Y. W., Deng, B., Fields, J. G., DeSarno, M., Loi, R., Hoffman, A. M., Bianchi, J., Dacken, B., Petersen, T., Wagner, D. E., Weiss, D. J.: Comparative decellularization and recellularization of wild-type and alpha 1,3 galactosyltransferase knockout pig lungs: A model for ex vivo xenogeneic lung bioengineering and transplantation. Tissue Eng Part C Methods 22(8): 725-39, 2016.
Rettmer, H., Hoffman, A. M., Lanz, S., Oertly, M., Gerber, V.: Owner-reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting. Equine Vet J 47(3): 291-5, 2015.
Graham, J. E., Meola, D. M., Kini, N. R., Hoffman, A. M.: Comparison of the effects of glycerol, dimethyl sulfoxide, and hydroxyethyl starch solutions for cryopreservation of avian red blood cells. Am J Vet Res 76(6): 487-93, 2015.
Houtsma, A., Bedenice, D., Pusterla, N., Pugliese, B., Mapes, S., Hoffman, A. M., Paxson, J., Rozanski, E., Mukherjee, J., Wigley, M., Mazan, M. R.: Association between inflammatory airway disease of horses and exposure to respiratory viruses: a case control study. Multidiscip Respir Med 10: 33, 2015.
Cruz, F. F., Borg, Z. D., Goodwin, M., Sokocevic, D., Wagner, D. E., Coffey, A., Antunes, M., Robinson, K. L., Mitsialis, S. A., Kourembanas, S., Thane, K., Hoffman, A. M., McKenna, D. H., Rocco, P. R., Weiss, D. J.: Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice. Stem Cells Transl Med 4(11): 1302-16, 2015.