Brian Flesner
Contact information
Hill Pavillion - PennVet
380 S. University Ave.
Philadelphia, PA 19104
380 S. University Ave.
Philadelphia, PA 19104
Email:
flesner@upenn.edu
flesner@upenn.edu
Publications
Education:
DVM (Veterinary Medicine)
University of Illinois, 2010.
MSc (Medical Oncology)
University of Missouri, 2014.
Permanent linkDVM (Veterinary Medicine)
University of Illinois, 2010.
MSc (Medical Oncology)
University of Missouri, 2014.
Description of Clinical Expertise
Oncology clinical trials, especially in canine osteosarcoma and cancer pain.Description of Research Expertise
The current focus of my research is based on translational models of naturally occurring cancer in companion animals. Specifically, I focus on chemotoxicity and chemotherapy mechanisms of action, improving chemotherapy efficacy with novel combination protocols or investigational drugs, improving the treatment paradigm for canine (and thereby human) osteosarcoma, and understanding and treating cancer pain.Selected Publications
Reising, A. J., Donnelly, L. L., Flesner, B. K., Maitz, C. A., Bryan, J. N.: Solitary osseous plasmacytomas in dogs: 13 cases (2004-2019). Journal of Small Animal Practice 2021.Musser, M. L., Curran, K. M., Flesner, B. K., Johannes, C. M.: A retrospective evaluation of chemotherapy overdoses in dogs and cats. Front Vet Sci 8: 718967, 2021.
Middleton, J. R., Getchell, R. G., Flesner, B. K., Hess, W. J., Johnson, P. J., Scarfe, A. D., Starling, D. E.: Considerations related to the use of molecular diagnostic tests in veterinary clinical and regulatory practice. Journal of the American Veterinary Medical Association 259(6): 590-595, 2021.
LeBlanc, A. K., Mazcko, C. N., Cherukuri, A., Berger, E. P., Kisseberth, W. C., Brown, M. E., Lana, S. E., Weishaar, K., Flesner, B. K., Bryan, J. N., Vail, D. M., Burton, J. H., Willcox, J. L., Mutsaers, A. J., Woods, J. P., Northrup, N. C., Saba, C., Curran, K. M., Leeper, H., Wilson-Robles, H., Wustefeld-Janssens, B. G., Lindley, S., Smith, A. N., Dervisis, N., Klahn, S., Higginbotham, M. L., Wouda, R. M., Krick, E., Mahoney, J. A., London, C. A., Barber, L. G., Balkman, C. E., McCleary-Wheeler, A. L., Suter, S. E., Martin, O., Borgatti, A., Burgess, K., Childress, M. O., Fidel, J. L., Allstadt, S. D., Gustafson, D. L., Selmic, L. E., Khanna, C., Fan, T. M.: Adjuvant sirolimus does not improve outcome in pet dogs receiving standard-of-care therapy for appendicular osteosarcoma: A prospective, randomized trial of 324 dogs. Clin Cancer Res 27(11): 3005-3016, 2021.
Harrison, N. J., Shumway, K. L., Hansen, S. A., Maitz, C. A., Thombs, L. A., Flesner, B. K.: A 3D-printed apparatus for imaging multiple rats simultaneously. Comparative Medicine 71(2): 116-122, 2021.
L. Ashworth H, K. Flesner B, J. Norquest C, A. Maitz C: Nasal angiofibroma treatment outcome using intensity-modulated radiation therapy in a dog. Veterinary Radiology & Ultrasound 62(4): e40-e43, 2021.
Weissman, Marc, Donnelly, Lindsay L, Branson, Keith, Glahn, Anastasia, Nagy, Dusty, Havis, Brett, Johnson, Gayle, Flesner, Brian K: Electrochemotherapy for a cutaneous squamous cell carcinoma in a Vietnamese pot-bellied Pig (Susscrofa). Journal of Exotic Pet Medicine 34: 37-43, 2020.
Flesner, B. K., Wood, G. W., Gayheart-Walsten, P., Sonderegger, F. L., Henry, C. J., Tate, D. J., Bechtel, S. M., Donnelly, L. L., Johnson, G. C., Kim, D. Y., Wahaus, T. A., Bryan, J. N., Reyes, N.: Autologous cancer cell vaccination, adoptive T-cell transfer, and interleukin-2 administration results in long-term survival for companion dogs with osteosarcoma. Journal of Veterinary Internal Medicine 34(5): 2056-2067, 2020.
Dedeaux, A. M., Flesner, B. K., Reinhart, J. M., Langohr, I. M., Husnik, R., Geraci, S. N., Taboada, J., Rademacher, N., Thombs, L. A., Bryan, J. N., Trepanier, L. A., Boudreaux, B. B.: Biochemical, functional, and histopathologic characterization of lomustine-induced liver injury in dogs. American Journal of Veterinary Research 81(10): 810-820, 2020.
Schaefer, E. A. F., Chu, S., Pearce, J. W., Bryan, J. N., Flesner, B. K.: Papillomavirus DNA not detected in canine lobular orbital adenoma and normal conjunctival tissue. BMC Veterinary Research 15(1): 226, 2019.
Flesner, B. K., Fletcher, J. M., Smithee, T., Boudreaux, B.: Long-term survival and glycemic control with toceranib phosphate and prednisone for a metastatic canine insulinoma. Journal of the American Animal Hospital Association 55(1): e55105, 2019.