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Luca Musante
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Director of Extracellular Vesicle Core, University of Pennsylvania School of Veterinary Medicine
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Contact information
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Penn Vet-Rosenthal
35 3800 Spruce Street
Philadelphia, PA 19104
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35 3800 Spruce Street
Philadelphia, PA 19104
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Office: 215-573-8215
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Email:
musante@upenn.edu
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musante@upenn.edu
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Publications
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Links
b5 Search PubMed for articles
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b5 Search PubMed for articles
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Education:
21 8 MSc 2e (Biochemistry & Clinical Chemistry) c
4f University of Modena and Reggio Emilia, Modena, Italy , 2000.
21 8 PhD 22 (Experimental Medicine) c
3a University of Pavia, Pavia, Italy, 2005.
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Permanent link21 8 MSc 2e (Biochemistry & Clinical Chemistry) c
4f University of Modena and Reggio Emilia, Modena, Italy , 2000.
21 8 PhD 22 (Experimental Medicine) c
3a University of Pavia, Pavia, Italy, 2005.
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f0 • Manage all aspects of the laboratory, including capital acquisitions and service contracts, training and education related to EV Core Services and instruments, and quality assurance/control of instrumentation and processes.
fe • Communicate fees for service, assist in study design, website design, education (seminars), and updates through communications, maintaining expertise in the use of the facility and being available for assistance with planning experiments.
a2 • Advise graduate students, Post-Doctoral Fellows, and Faculty at U Penn and outside U Penn about techniques and specific activities in the EV Core.
87 • Responsible for keeping track of all ongoing projects and make sure all protocols are properly documented and invoiced.
37 • Analyze the facility operating metrics.
16c • Assess the impact of developing technologies on current facility operations and present the recommendations to the PI (Dr. Andrew Hoffman). Advise the PI on future acquisitions and industry interactions, grant opportunities including grant writing for purposes of capital priorities, and direction of the EV Core with respect to scientific trends.
90 • Review and update the long-range plans, ensuring coordination between individual core plans and the core’s scientific mission.
d6 • Encourage cross collaboration through the creation of a strong network of EV researchers both in the academia and the industry promoting sharing of rigorous, reproducible data following MISEV guidelines.
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Description of Research Expertise
12e Direct the EV Core with the mission to offer the UPenn community access to service, training and the appropriate instrumentation related to isolation and minimal characterization of EVs with the aim to encourage procedure standardization to maintain high standards in EV research.f0 • Manage all aspects of the laboratory, including capital acquisitions and service contracts, training and education related to EV Core Services and instruments, and quality assurance/control of instrumentation and processes.
fe • Communicate fees for service, assist in study design, website design, education (seminars), and updates through communications, maintaining expertise in the use of the facility and being available for assistance with planning experiments.
a2 • Advise graduate students, Post-Doctoral Fellows, and Faculty at U Penn and outside U Penn about techniques and specific activities in the EV Core.
87 • Responsible for keeping track of all ongoing projects and make sure all protocols are properly documented and invoiced.
37 • Analyze the facility operating metrics.
16c • Assess the impact of developing technologies on current facility operations and present the recommendations to the PI (Dr. Andrew Hoffman). Advise the PI on future acquisitions and industry interactions, grant opportunities including grant writing for purposes of capital priorities, and direction of the EV Core with respect to scientific trends.
90 • Review and update the long-range plans, ensuring coordination between individual core plans and the core’s scientific mission.
d6 • Encourage cross collaboration through the creation of a strong network of EV researchers both in the academia and the industry promoting sharing of rigorous, reproducible data following MISEV guidelines.
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359 Erdbrügger, U., Blijdorp, C. J., Bijnsdorp, I. V., Borràs, F. E., Burger, D., Bussolati, B., Byrd, J. B., Clayton, A., Dear, J. W., Falcón-Pérez, J. M., Grange, C., Hill, A. F., Holthöfer, H., Hoorn, E. J., Jenster, G., Jimenez, C. R., Junker, K., Klein, J., Knepper, M. A., Koritzinsky, E. H., Luther, J. M., Lenassi, M., Leivo, J., Mertens, I., Musante, L., Oeyen, E., Puhka, M., van Royen, M. E., Sánchez, C., Soekmadji, C., Thongboonkerd, V., van Steijn, V., Verhaegh, G., Webber, J. P., Witwer, K., Yuen, P. S. T., Zheng, L., Llorente, A., Martens-Uzunova, E. S.: Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles 10(7): e12093, 2021.
16e Musante, L., Bontha, S. V., La Salvia, S., Fernandez-Piñeros, A., Lannigan, J., Le, T. H., Mas, V., Erdbrügger, U.: Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet - a neglected source for uEVs. Scientific Reports 10(1): 3701, 2020.
134 La Salvia, S., Musante, L., Lannigan, J., Gigliotti, J. C., Le, T. H., Erdbrügger, U.: T cell-derived extracellular vesicles are elevated in essential HTN. American Journal of Physiology: Renal Physiology 319(5): F868-f875, 2020.
145 Good, M. E., Musante, L., La Salvia, S., Howell, N. L., Carey, R. M., Le, T. H., Isakson, B. E., Erdbrügger, U.: Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries. Hypertension 75(1): 218-228, 2020.
14a Eichner, N. Z. M., Gilbertson, N. M., Heiston, E. M., Musante, L., L. A. Salvia S, Weltman, A., Erdbrugger, U., Malin, S. K.: Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes. Med Sci Sports Exerc 52(3): 729-735, 2020.
125 Musante, L., Tataruch, D., Gu, D., Liu, X., Forsblom, C., Groop, P. H., Holthofer, H.: Proteases and protease inhibitors of urinary extracellular vesicles in diabetic nephropathy. J Diabetes Res 2015: 289734, 2015.
104 Musante, L., Saraswat, M., Ravidà, A., Byrne, B., Holthofer, H.: Recovery of urinary nanovesicles from ultracentrifugation supernatants. Nephrol Dial Transplant 28(6): 1425-33, 2013.
1aa Musante, L., Candiano, G., Petretto, A., Bruschi, M., Dimasi, N., Caridi, G., Pavone, B., Del Boccio, P., Galliano, M., Urbani, A., Scolari, F., Vincenti, F., Ghiggeri, G. M.: Active focal segmental glomerulosclerosis is associated with massive oxidation of plasma albumin. Journal of the American Society of Nephrology 18(3): 799-810, 2007.
160 Musante, L., Candiano, G., Bruschi, M., Zennaro, C., Carraro, M., Artero, M., Giuffrida, M. G., Conti, A., Santucci, A., Ghiggeri, G. M.: Characterization of plasma factors that alter the permeability to albumin within isolated glomeruli. Proteomics 2(2): 197-205, 2002.
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Selected Publications
146 Heiston, E. M., Ballantyne, A., La Salvia, S., Musante, L., Erdbrügger, U., Malin, S. K.: Acute exercise decreases insulin-stimulated extracellular vesicles in conjunction with augmentation index in adults with obesity. Journal of Physiology 2022.359 Erdbrügger, U., Blijdorp, C. J., Bijnsdorp, I. V., Borràs, F. E., Burger, D., Bussolati, B., Byrd, J. B., Clayton, A., Dear, J. W., Falcón-Pérez, J. M., Grange, C., Hill, A. F., Holthöfer, H., Hoorn, E. J., Jenster, G., Jimenez, C. R., Junker, K., Klein, J., Knepper, M. A., Koritzinsky, E. H., Luther, J. M., Lenassi, M., Leivo, J., Mertens, I., Musante, L., Oeyen, E., Puhka, M., van Royen, M. E., Sánchez, C., Soekmadji, C., Thongboonkerd, V., van Steijn, V., Verhaegh, G., Webber, J. P., Witwer, K., Yuen, P. S. T., Zheng, L., Llorente, A., Martens-Uzunova, E. S.: Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles 10(7): e12093, 2021.
16e Musante, L., Bontha, S. V., La Salvia, S., Fernandez-Piñeros, A., Lannigan, J., Le, T. H., Mas, V., Erdbrügger, U.: Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet - a neglected source for uEVs. Scientific Reports 10(1): 3701, 2020.
134 La Salvia, S., Musante, L., Lannigan, J., Gigliotti, J. C., Le, T. H., Erdbrügger, U.: T cell-derived extracellular vesicles are elevated in essential HTN. American Journal of Physiology: Renal Physiology 319(5): F868-f875, 2020.
145 Good, M. E., Musante, L., La Salvia, S., Howell, N. L., Carey, R. M., Le, T. H., Isakson, B. E., Erdbrügger, U.: Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries. Hypertension 75(1): 218-228, 2020.
14a Eichner, N. Z. M., Gilbertson, N. M., Heiston, E. M., Musante, L., L. A. Salvia S, Weltman, A., Erdbrugger, U., Malin, S. K.: Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes. Med Sci Sports Exerc 52(3): 729-735, 2020.
125 Musante, L., Tataruch, D., Gu, D., Liu, X., Forsblom, C., Groop, P. H., Holthofer, H.: Proteases and protease inhibitors of urinary extracellular vesicles in diabetic nephropathy. J Diabetes Res 2015: 289734, 2015.
104 Musante, L., Saraswat, M., Ravidà, A., Byrne, B., Holthofer, H.: Recovery of urinary nanovesicles from ultracentrifugation supernatants. Nephrol Dial Transplant 28(6): 1425-33, 2013.
1aa Musante, L., Candiano, G., Petretto, A., Bruschi, M., Dimasi, N., Caridi, G., Pavone, B., Del Boccio, P., Galliano, M., Urbani, A., Scolari, F., Vincenti, F., Ghiggeri, G. M.: Active focal segmental glomerulosclerosis is associated with massive oxidation of plasma albumin. Journal of the American Society of Nephrology 18(3): 799-810, 2007.
160 Musante, L., Candiano, G., Bruschi, M., Zennaro, C., Carraro, M., Artero, M., Giuffrida, M. G., Conti, A., Santucci, A., Ghiggeri, G. M.: Characterization of plasma factors that alter the permeability to albumin within isolated glomeruli. Proteomics 2(2): 197-205, 2002.
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