Wojciech K Panek
Diplomate, American College of Veterinary Internal Medicine (Neurology). Assistant Professor, Neurology and Neurosurgery, Clinician Educator, University of Pennsylvania School of Veterinary Medicine
Contact information
Department of Clinical Sciences and Advanced Medicine
University of Pennsylvania, School of Veterinary Medicine
Philadelphia, PA 19104
University of Pennsylvania, School of Veterinary Medicine
Philadelphia, PA 19104
Office: 215 746 8387
Fax: N/A
Lab: 215 746 8387
Fax: N/A
Lab: 215 746 8387
Email:
wkp@upenn.edu
wkp@upenn.edu
Publications
Education:
DVM (Veterinary Medicine)
Wroclaw University of Environmental and Life Sciences, Poland., 2013.
DACVIM (Small Animal Neurology & Neurosurgery)
American College of Veterinary Internal Medicine (ACVIM), 2023.
Permanent linkDVM (Veterinary Medicine)
Wroclaw University of Environmental and Life Sciences, Poland., 2013.
DACVIM (Small Animal Neurology & Neurosurgery)
American College of Veterinary Internal Medicine (ACVIM), 2023.
Description of Clinical Expertise
My clinical interests focus on management of canine patients with spontaneously occurring brain and spinal cord tumors as well as age-related neurodegenerative disorders.Description of Research Expertise
My research includes translational neuro-oncology and neuro-aging and primarily focuses on developing a comprehensive understanding of the regulatory signals that govern the immune system mobilization and/or exhaustion in patients suffering from CNS tumors and Canine Cognitive Dysfunction.Selected Publications
Mondino, A., Khan, M., Case, B., Fefer, G., Panek, W. K., Gruen, M. E., Olby, N. J.: Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs. Front Vet Sci 10: 1150590, 2023.Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., Gruen, M. E., Olby, N. J., Mowat, F. M.: Age-associated changes in electroretinography measures in companion dogs. Doc Ophthalmol 147(1): 15-28, 2023.
Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., Olby, N. J.: Relationship between hearing, cognitive function, and quality of life in aging companion dogs. Journal of Veterinary Internal Medicine 36(5): 1708-1718, 2022.
Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., Murdoch, D. M., Case, B., Olby, N. J., Gruen, M. E.: Use of cognitive testing, questionnaires, and plasma biomarkers to quantify cognitive impairment in an aging pet dog population. Journal of Alzheimer's Disease 87(3): 1367-1378, 2022.
Hebel, M., Panek, W. K., Ruszkowski, J. J., Nabzdyk, M., Niedzielski, D., Pituch, K. C., Jackson, A. M., Kielbowicz, M., Pomorska-Mol, M.: Computed tomography findings in a cohort of 169 dogs with elbow dysplasia - a retrospective study. BMC Veterinary Research 17(1): 296, 2021.
Panek, W. K., Murdoch, D. M., Gruen, M. E., Mowat, F. M., Marek, R. D., Olby, N. J.: Plasma amyloid beta concentrations in aged and cognitively impaired pet dogs. Molecular Neurobiology 58(2): 483-489, 2021.
Kanojia, D., Panek, W. K., Cordero, A., Fares, J., Xiao, A., Savchuk, S., Kumar, K., Xiao, T., Pituch, K. C., Miska, J., Zhang, P., Kam, K. L., Horbinski, C., Balyasnikova, I. V., Ahmed, A. U., Lesniak, M. S.: BET inhibition increases betaIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine. Science Translational Medicine 12(558), 2020.
Rashidi, A., Miska, J., Lee-Chang, C., Kanojia, D., Panek, W. K., Lopez-Rosas, A., Zhang, P., Han, Y., Xiao, T., Pituch, K. C., Kim, J. W., Talebian, M., Fares, J., Lesniak, M. S.: GCN2 is essential for CD8(+) T cell survival and function in murine models of malignant glioma. Cancer Immunology, Immunotherapy 69(1): 81-94, 2020.
Panek, W. K., Gruen, M. E., Murdoch, D. M., Marek, R. D., Stachel, A. F., Mowat, F. M., Saker, K. E., Olby, N. J.: Plasma neurofilament light chain as a translational biomarker of aging and neurodegeneration in dogs. Molecular Neurobiology 57(7): 3143-3149, 2020.
Cordero, A., Kanojia, D., Miska, J., Panek, W. K., Xiao, A., Han, Y., Bonamici, N., Zhou, W., Xiao, T., Wu, M., Ahmed, A. U., Lesniak, M. S.: FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis. Oncogene 38(37): 6445-6460, 2019.
Zhang, P., Miska, J., Lee-Chang, C., Rashidi, A., Panek, W. K., An, S., Zannikou, M., Lopez-Rosas, A., Han, Y., Xiao, T., Pituch, K. C., Kanojia, D., Balyasnikova, I. V., Lesniak, M. S.: Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma. Proceedings of the National Academy of Sciences of the United States of America 116(47): 23714-23723, 2019.
Panek, W. K., Pituch, K. C., Miska, J., Kim, J. W., Rashidi, A., Kanojia, D., Lopez-Rosas, A., Han, Y., Yu, D., Chang, C. L., Kane, J. R., Zhang, P., Cordero, A., Lesniak, M. S.: Local application of autologous platelet-rich fibrin patch (PRF-P) suppresses regulatory T cell recruitment in a murine glioma model. Molecular Neurobiology 56(7): 5032-5040, 2019.
Miska, J., Lee-Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. S., Lesniak, M. S.: HIF-1alpha is a metabolic switch between glycolytic-driven migration and oxidative phosphorylation-driven immunosuppression of tregs in glioblastoma. Cell Reports 27(1): 226-237 e4, 2019.
Kim, J. W., Kane, J. R., Panek, W. K., Young, J. S., Rashidi, A., Yu, D., Kanojia, D., Hasan, T., Miska, J., Gomez-Lim, M. A., Ulasov, I. V., Balyasnikova, I. V., Ahmed, A. U., Wainwright, D. A., Lesniak, M. S.: A dendritic cell-targeted adenoviral vector facilitates adaptive immune response against human glioma antigen (CMV-IE) and prolongs survival in a human glioma tumor model. Neurotherapeutics 15(4): 1127-1138, 2018.
Pituch, K. C., Miska, J., Krenciute, G., Panek, W. K., Li, G., Rodriguez-Cruz, T., Wu, M., Han, Y., Lesniak, M. S., Gottschalk, S., Balyasnikova, I. V.: Adoptive transfer of IL13Ralpha2-specific chimeric antigen receptor t cells creates a pro-inflammatory environment in glioblastoma. Molecular Therapy 26(4): 986-995, 2018.
Kim, Julius W, Pituch, Katarzyna C, Xiao, Annie, Young, Jacob S, Panek, Wojciech K, Muroski, Megan E, Rashidi, Aida, Kane, J Robert, Kanojia, Deepak, Lesniak, Maciej S: Gene/viral treatment approaches for malignant brain cancer. Elsevier, Page: 211-227, 2018.
Kim, J. W., Miska, J., Young, J. S., Rashidi, A., Kane, J. R., Panek, W. K., Kanojia, D., Han, Y., Balyasnikova, I. V., Lesniak, M. S.: A comparative study of replication-incompetent and -competent adenoviral therapy-mediated immune response in a murine glioma model. Mol Ther Oncolytics 5: 97-104, 2017.
Panek, W. K., Kane, J. R., Young, J. S., Rashidi, A., Kim, J. W., Kanojia, D., Lesniak, M. S.: Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma. Oncotarget 8(51): 89391-89405, 2017.
Panek, W. K., Khan, O. F., Yu, D., Lesniak, M. S.: Multiplexed nanomedicine for brain tumors: nanosized Hercules to tame our Lernaean Hydra inside? Nanomedicine (Lond) 12(20): 2435-2439, 2017.
Yu, D., Khan, O. F., Suva, M. L., Dong, B., Panek, W. K., Xiao, T., Wu, M., Han, Y., Ahmed, A. U., Balyasnikova, I. V., Zhang, H. F., Sun, C., Langer, R., Anderson, D. G., Lesniak, M. S.: Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression. Proceedings of the National Academy of Sciences of the United States of America 114(30): E6147-E6156, 2017.