Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.
Erion Renske, King Anna N, Wu Gang, Hogenesch John B, Sehgal Amita: Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue. eLife 5, Apr 2016.
Zhang Ray, Podtelezhnikov Alexei A, Hogenesch John B, Anafi Ron C: Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA). Journal of biological rhythms Mar 2016.
Vaquero-Garcia Jorge, Barrera Alejandro, Gazzara Matthew R, González-Vallinas Juan, Lahens Nicholas F, Hogenesch John B, Lynch Kristen W, Barash Yoseph: A new view of transcriptome complexity and regulation through the lens of local splicing variations. eLife 5, Feb 2016.
Ma Di, Liu Tongyu, Chang Lin, Rui Crystal, Xiao Yuanyuan, Li Siming, Hogenesch John B, Chen Y Eugene, Lin Jiandie D: The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis. The Journal of biological chemistry 290(52): 31003-12, Dec 2015.
DeBruyne Jason P, Baggs Julie E, Sato Trey K, Hogenesch John B: Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock. Proceedings of the National Academy of Sciences of the United States of America 112(40): 12420-5, Oct 2015.
Jang Christopher, Lahens Nicholas F, Hogenesch John B, Sehgal Amita: Ribosome profiling reveals an important role for translational control in circadian gene expression. Genome research Sep 2015.
Hayer Katharina E, Pizarro Angel, Lahens Nicholas F, Hogenesch John B, Grant Gregory R: Benchmark analysis of algorithms for determining and quantifying full-length mRNA splice forms from RNA-seq data. Bioinformatics (Oxford, England) Sep 2015.
Altman Brian J, Hsieh Annie L, Sengupta Arjun, Krishnanaiah Saikumari Y, Stine Zachary E, Walton Zandra E, Gouw Arvin M, Venkataraman Anand, Li Bo, Goraksha-Hicks Pankuri, Diskin Sharon J, Bellovin David I, Simon M Celeste, Rathmell Jeffrey C, Lazar Mitchell A, Maris John M, Felsher Dean W, Hogenesch John B, Weljie Aalim M, Dang Chi V: MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell metabolism Sep 2015.
Lee Yool, Jang A Reum, Francey Lauren J, Sehgal Amita, Hogenesch John B: KPNB1 mediates PER/CRY nuclear translocation and circadian clock function. eLife 4, Aug 2015.
Wolman Marc A, Jain Roshan A, Marsden Kurt C, Bell Hannah, Skinner Julianne, Hayer Katharina E, Hogenesch John B, Granato Michael: A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning. Neuron 85(6): 1200-11, Mar 2015.
back to top
Last updated: 04/16/2016
The Trustees of the University of Pennsylvania