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a8
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1b
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Akhilesh Basi Reddy, MA MB BChir PhD
78
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Professor of Systems Pharmacology and Translational Therapeutics
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3
8a
Member, Institute for Translational Medicine and Therapeutics (ITMAT)
57
Member, Diabetes Research Center
6f
Member, Penn Institute of Diabetes and Metabolism (IDOM)
83
Member, Penn Center for Research on Coronavirus and Other Emerging Pathogens
6a
Member, Circadian rhythms and Sleep Institute (CSI)
5f
Member, Penn Institute of RNA Innovation
7c
Member, Circadian rhythms and Sleep Institute (CSI) Seminar Committee
5e
Member, Institute of Structural Biology
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Department: Systems Pharmacology and Translational Therapeutics
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1
b
1d
46
Contact information
78
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10-125 Smilow Center for Translational Research
Philadelphia, PA 19104
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Philadelphia, PA 19104
35
ab
12
1f
Graduate Group Affiliations
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3
2
4
b
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6a
- Pharmacology 6b
- Cell and Molecular Biology 64
- Neuroscience e
13
Education:
21 7 BA 24 (Medical Sciences Tripos) c
34 University of Cambridge, UK, 1998.
21 8 PhD c
4b MRC Laboratory of Molecular Biology, Cambridge, UK, 2003.
21 d MB BChir c
34 University of Cambridge, UK, 2003.
21 7 MA c
34 University of Cambridge, UK, 2012.
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27
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Permanent link21 7 BA 24 (Medical Sciences Tripos) c
34 University of Cambridge, UK, 1998.
21 8 PhD c
4b MRC Laboratory of Molecular Biology, Cambridge, UK, 2003.
21 d MB BChir c
34 University of Cambridge, UK, 2003.
21 7 MA c
34 University of Cambridge, UK, 2012.
c
2 29
21
1e
1d
24
5e
71
e 29
27
Description of Clinical Expertise
21 General Neurology71
Description of Research Expertise
b9 Circadian clocks, Sleep, Metabolism, Neural circuits, Deep Learning, Machine Intelligence, Digital Biology, Programmable Biology, Large language models (LLMs), AI safetye 29
23
167 O'Neill, J. S., G. van Ooijen, L. E. Dixon, C. Troein, F. Corellou, F. Y. Bouget, A. B. Reddy* and A. J. Millar*: Circadian rhythms persist without transcription in a eukaryote. Nature 469(7331): 554-558, 2011 Notes: *Joint senior author. My lab performed the molecular biology aspects.
186 Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB*.: Peroxiredoxins are conserved markers of circadian rhythms. Nature 485(7399): 459-64, 2012 Notes: *Senior author.
125 Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O'Neill JS, Reddy AB.: Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA 113(36): 10085-90, 2016.
129 Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB*.: The pentose phosphate pathway regulates the circadian clock. Cell Metabolism 24(3): 462-73, 2016.
1c2 Henslee EA, Crosby P, Kitcatt SJ, Parry JSW, Bernardini A, Abdallat RG, Braun G, Fatoyinbo HO, Harrison EJ, Edgar RS, Hoettges KF, Reddy AB, Jabr RI, von Schantz M, O'Neill JS, Labeed FH.: Rhythmic potassium transport regulates the circadian clock in human red blood cells. Nature Communications 8(1): 1978, 2017 Notes: Provided funding, experimental design input and reagents.
130 Sandipan Ray*, Utham K. Valekunja*, Alessandra Stangherlin, Steven A. Howell, Ambrosius P. Snijders, Gopinath Damodaran, Akhilesh B. Reddy: Circadian rhythms in the absence of the clock gene Bmal1. Science 367(6479): 800-806, 2020.
162 Ratnasekhar Ch, Guillaume Rey, Sandipan Ray, Pawan K. Jha, Paul C. Driscoll, Mariana Silva Dos Santos, Dania M. Malik, Radoslaw Lach, Aalim M. Weljie, James I. MacRae, Utham K. Valekunja, and Akhilesh B. Reddy: Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells 3b Nature Communications 12(1), 2021.
7a Pawan K Jha, Utham K Valekunja, Sandipan Ray, Mathieu Nollet, Akhilesh B Reddy a8 : Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep. Communications Biology 5(1): 846, 2022.
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Selected Publications
136 O'Neill, J. S. and A. B. Reddy*: Circadian clocks in human red blood cells. Nature 469(7331): 498-503, 2011 Notes: *Senior author. Also covered by News & Views editorial by Bass & Takehashi in the same issue, Nature 469:476–478 (2011).167 O'Neill, J. S., G. van Ooijen, L. E. Dixon, C. Troein, F. Corellou, F. Y. Bouget, A. B. Reddy* and A. J. Millar*: Circadian rhythms persist without transcription in a eukaryote. Nature 469(7331): 554-558, 2011 Notes: *Joint senior author. My lab performed the molecular biology aspects.
186 Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB*.: Peroxiredoxins are conserved markers of circadian rhythms. Nature 485(7399): 459-64, 2012 Notes: *Senior author.
125 Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O'Neill JS, Reddy AB.: Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA 113(36): 10085-90, 2016.
129 Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB*.: The pentose phosphate pathway regulates the circadian clock. Cell Metabolism 24(3): 462-73, 2016.
1c2 Henslee EA, Crosby P, Kitcatt SJ, Parry JSW, Bernardini A, Abdallat RG, Braun G, Fatoyinbo HO, Harrison EJ, Edgar RS, Hoettges KF, Reddy AB, Jabr RI, von Schantz M, O'Neill JS, Labeed FH.: Rhythmic potassium transport regulates the circadian clock in human red blood cells. Nature Communications 8(1): 1978, 2017 Notes: Provided funding, experimental design input and reagents.
130 Sandipan Ray*, Utham K. Valekunja*, Alessandra Stangherlin, Steven A. Howell, Ambrosius P. Snijders, Gopinath Damodaran, Akhilesh B. Reddy: Circadian rhythms in the absence of the clock gene Bmal1. Science 367(6479): 800-806, 2020.
162 Ratnasekhar Ch, Guillaume Rey, Sandipan Ray, Pawan K. Jha, Paul C. Driscoll, Mariana Silva Dos Santos, Dania M. Malik, Radoslaw Lach, Aalim M. Weljie, James I. MacRae, Utham K. Valekunja, and Akhilesh B. Reddy: Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells 3b Nature Communications 12(1), 2021.
7a Pawan K Jha, Utham K Valekunja, Sandipan Ray, Mathieu Nollet, Akhilesh B Reddy a8 : Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep. Communications Biology 5(1): 846, 2022.
2c