Jennifer L Orthmann-Murphy, MD, PhD
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
B.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001.
University of Pennsylvania Perelman School of Medicine, 2007.
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010.
Researcher in laboratory of Steven Scherer, University of Pennsylvania, 2008-2008.
Intern, Internal Medicine, University of Pennsylvania, 2010-2011.
Resident, Neurology, University of Pennsylvania, 2011-2014.
R25 Trainee, Neuroscience, University of Pennsylvania, 2013-2014.
Postdoctoral fellow, Solomon Snyder Department of Neuroscience, Johns Hopkins School of Medicine, 2014-2018.
Clinical Neuroimmunology and Postdoctoral Research Fellow, Johns Hopkins School of Medicine, Departments of Neuroscience and Neurology, 2014-2018.
Elective clinic work, Neurogenetics clinic (KKI); Neurogenetics/Hereditary Spastic Paraplegia clinic (NIH) 2016; Leukodystrophy clinic (CHOP) 2017, 2016-2018.
Board Certification in Neurology, American Board of Psychiatry and Neurology Specialty, 2014.
Description of Research ExpertiseResearch Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.
Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination
Techniques: multiphoton imaging
Description of Clinical ExpertiseMultiple Sclerosis, Neuroimmunology, Inherited White Matter Disorders
Selected PublicationsOrthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Oligodendrogenesis following cortical demyelination generates a novel myelination pattern Platform Presentation at the American Academy of Neurology 71st Annual Meeting in Philadelphia, PA May 2019.
Mu W, Schiess N, Orthmann-Murphy JL, El-Hattab AW.: The utility of whole exome sequencing in diagnosing neurological disorders in adults from a highly consanguineous population. J Neurogenet Page: 10.1080/01677063.2018.1555249, February 2019.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Poster presentation at the American Neurological Association in Atlanta, GA October 2018.
Hughes EG*, Orthmann-Murphy JL*, Langseth AJ, Bergles DE: Myelin remodeling through experience dependent oligodendrogenesis in the adult somatosensory cortex. Nature Neuroscience 21(5): 696-706, May 2018.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Late-Breaking Topic in Myelin Disease: Mechanisms and Treatments session. Poster and Platform Presentation at the Myelin Gordon Research Conference in Ventura, CA. March 2018.
Nahhas N, Conant A, Orthmann-Murphy J, et al.: Pelizaeus-Merzbacher-Like Disease 1. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. (eds.). Seattle (WA): University of Washington, Seattle; 1993-2018. December 2017 Notes: Available from: https://www.ncbi.nlm.nih.gov/books/NBK470716/
Al Dhaibani MA, El-Hattab AW, Holroyd KB, Orthmann-Murphy J, Larson VA, Siddiqui KA, Szolics M, Schiess N: Novel mutation in the KCNJ10 gene in three siblings with seizures, ataxia and no electrolyte abnormalities. J Neurogenet Page: 1-5, November 2017.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE: Remyelination of specific axonal domains in the somatosensory cortex. Dynamic Poster presentation at Society for Neuroscience in Washington, DC November 2017.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Remyelination of the mouse somatosensory cortex defined by longitudinal two photon in vivo imaging. Poster presentation at National MS Society Tykeson Fellows Conference in Denver, CO November 2017.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE: Remyelination of specific axonal domains in the somatosensory cortex. Poster presentation at Johns Hopkins School of Medicine Department of Neuroscience Annual Retreat in Cambridge, MD September 2017.