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Jennifer L Orthmann-Murphy, MD, PhD

Assistant Professor of Neurology
Co-Director of Age Span Fellowship in MS/Neuroinflammatory Disorders, University of Pennsylvania
Faculty, Mahoney Institute for Neurosciences
Department: Neurology

Contact information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3606
Lab: 215-898-8282
Graduate Group Affiliations
B.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001.
Ph.D. (Neuroscience)
University of Pennsylvania Perelman School of Medicine, 2007.
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010.
Post-Graduate Training
Researcher in laboratory of Steven Scherer, University of Pennsylvania, 2008-2008.
Intern, Internal Medicine, University of Pennsylvania, 2010-2011.
Resident, Neurology, University of Pennsylvania, 2011-2014.
R25 Trainee, Neuroscience, University of Pennsylvania, 2013-2014.
Postdoctoral fellow, Solomon Snyder Department of Neuroscience, Johns Hopkins School of Medicine, 2014-2018.
Clinical Neuroimmunology and Postdoctoral Research Fellow, Johns Hopkins School of Medicine, Departments of Neuroscience and Neurology, 2014-2018.
Elective clinic work, Neurogenetics clinic (KKI); Neurogenetics/Hereditary Spastic Paraplegia clinic (NIH) 2016; Leukodystrophy clinic (CHOP) 2017, 2016-2018.
Board Certification in Neurology, American Board of Psychiatry and Neurology Specialty, 2014.
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Description of Research Expertise

Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.

Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination

Techniques: multiphoton imaging

Description of Clinical Expertise

Multiple Sclerosis, Neuroimmunology, Inherited White Matter Disorders

Selected Publications

Guo MH, ardakjian TM, Brzozowski MR, Scherer SS, Quinn C, Elman L, Orthmann-Murphy JL, Tropea TF, Ellis CA, Gonzalez-Alegre P : Temporal trends and yield of clinical diagnostic genetic testing in adult neurology. American Journal of Medical Genetics June 2021 Notes: https://doi.org/10.1002/ajmg.a.62372.

Jennifer L. Orthmann-Murphy: An Undiagnosed White Matter Disorders Neurogenetics Clinic. ACTRIMS Virtual Meeting 2020 Poster P100 2021.

Jennifer Orthmann-Murphy*, Cody L Call*, Gian C Molina-Castro, Yu Chen Hsieh, Matthew N Rasband, Peter A Calabresi, Dwight E Bergles. *Co-first authors: Remyelination alters the pattern of myelin in the cerebral cortex. eLife 2020.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Oligodendrogenesis following cortical demyelination generates a novel myelination pattern Platform Presentation at the American Academy of Neurology 71st Annual Meeting in Philadelphia, PA May 2019.

Mu W, Schiess N, Orthmann-Murphy JL, El-Hattab AW.: The utility of whole exome sequencing in diagnosing neurological disorders in adults from a highly consanguineous population. J Neurogenet Page: 10.1080/01677063.2018.1555249, February 2019.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Poster presentation at the American Neurological Association in Atlanta, GA October 2018.

Hughes EG*, Orthmann-Murphy JL*, Langseth AJ, Bergles DE: Myelin remodeling through experience dependent oligodendrogenesis in the adult somatosensory cortex. Nature Neuroscience 21(5): 696-706, May 2018.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Late-Breaking Topic in Myelin Disease: Mechanisms and Treatments session. Poster and Platform Presentation at the Myelin Gordon Research Conference in Ventura, CA. March 2018.

Nahhas N, Conant A, Orthmann-Murphy J, et al.: Pelizaeus-Merzbacher-Like Disease 1. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. (eds.). Seattle (WA): University of Washington, Seattle; 1993-2018. December 2017 Notes: Available from: https://www.ncbi.nlm.nih.gov/books/NBK470716/

Al Dhaibani MA, El-Hattab AW, Holroyd KB, Orthmann-Murphy J, Larson VA, Siddiqui KA, Szolics M, Schiess N: Novel mutation in the KCNJ10 gene in three siblings with seizures, ataxia and no electrolyte abnormalities. J Neurogenet Page: 1-5, November 2017.

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Last updated: 08/02/2021
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