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Jennifer L Orthmann-Murphy, MD, PhD

Assistant Professor of Neurology
Co-Director of Age Span Fellowship in MS/Neuroinflammatory Disorders, University of Pennsylvania
Faculty, Mahoney Institute for Neurosciences
Department: Neurology

Contact information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3606
Lab: 215-898-8282
Graduate Group Affiliations
B.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001.
Ph.D. (Neuroscience)
University of Pennsylvania Perelman School of Medicine, 2007.
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010.
Post-Graduate Training
Researcher in laboratory of Steven Scherer, University of Pennsylvania, 2008-2008.
Intern, Internal Medicine, University of Pennsylvania, 2010-2011.
Resident, Neurology, University of Pennsylvania, 2011-2014.
R25 Trainee, Neuroscience, University of Pennsylvania, 2013-2014.
Postdoctoral fellow, Solomon Snyder Department of Neuroscience, Johns Hopkins School of Medicine, 2014-2018.
Clinical Neuroimmunology and Postdoctoral Research Fellow, Johns Hopkins School of Medicine, Departments of Neuroscience and Neurology, 2014-2018.
Elective clinic work, Neurogenetics clinic (KKI); Neurogenetics/Hereditary Spastic Paraplegia clinic (NIH) 2016; Leukodystrophy clinic (CHOP) 2017, 2016-2018.
Board Certification in Neurology, American Board of Psychiatry and Neurology Specialty, 2014.
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Description of Research Expertise

Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.

Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination

Techniques: multiphoton imaging

Description of Clinical Expertise

Multiple Sclerosis, Neuroimmunology, Inherited White Matter Disorders

Selected Publications

Hannah Loo and Jennifer L Orthmann-Murphy: How do deep cortical microglia impair remyelination? Gordon Research Conference Poster - Glial Biology March 2023.

Rebecca L. Koch, Claudia Soler-Alfonso, Bridget T. Kiely, Akihiro Asai, Ariana L. Smith, Deeksha S. Bali, Peter B. Kang, Andrew P. Landstrom, H. Orhan Akman, T. Andrew Burrow, Jennifer L. Orthmann-Murphy, Deberah S. Goldman, Surekha Pendyal, Areeg H. El-Gharbawy, Stephanie L. Austin, Laura E. Case, Raphael Schiffmann, Michio Hirano, and Priya S. Kishnani: Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource. Molecular Genetics and Metabolism March 2023.

Joseph Gallegos, Hannah Loo, Thomas Malloy, Jennifer L Orthmann-Murphy: Does a toxic reactive astrocyte subtype influence oligodendrocyte recovery in the cortex? ACTRIMS Annual Meeting Poster 434 February 2023.

Al-alya Alsabah, Zehra Isik Hasiloglu, Rami Massie, Bernard Brais, *Jennifer Orthmann Murphy, *Roberta La Piana: Prevalence of Peripheral Nervous System Involvement in Adult Leukodystrophies. AAN annual meeting 2023.

Alexandra Kornbluh and Jennifer L Orthmann-Murphy: A Practical Approach to Longitudinal Neurological Care of Adults With X-linked Adrenoleukodystrophy and Adrenomyeloneuropathy (X-ALD/AMN). American Academy of Neurology Annual Meeting Poster P17-4.009 May 2022.

Papapetropoulos S, Pontius A,Finger E, Karrenbauer V, Lynch DS, Brennan M, Zappia1 S, Koehler W, Schoels L, Hayer SN, Konno T, Ikeuchi T, Lund T, Orthmann-Murphy J, Eichler E and Wszolek ZK: Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development. Frontiers in Neurology Page: https://doi.org/10.3389/fneur.2021.788168, February 2022.

Bloom MS, Orthmann-Murphy J. Grinspan JB: Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination ASN Neuro 14: doi: 10.1177/17590914221097510, Jan-Dec 2022.

Ahmad Almutlaq and Jennifer L Orthmann-Murphy: Adult Polyglucosan Body Disease: An Adult-Onset Leukodystrophy That Could Be Mistaken For Multiple Sclerosis. MULTIPLE SCLEROSIS JOURNAL - ACTRIMS Annual Meeting Poster 2022.

E Bae, R Shinohara, J Orthmann-Murphy: BOSS: Beta-mixture Unsupervised Oligodendrocytes Segmentation System. bioRxiv 2022.

Guo MH, ardakjian TM, Brzozowski MR, Scherer SS, Quinn C, Elman L, Orthmann-Murphy JL, Tropea TF, Ellis CA, Gonzalez-Alegre P : Temporal trends and yield of clinical diagnostic genetic testing in adult neurology. American Journal of Medical Genetics 185(10): 2922-2928, Oct 2021 Notes: https://doi.org/10.1002/ajmg.a.62372.

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Last updated: 09/01/2023
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