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Dennis L. Kolson, M.D., Ph.D.
3bProfessor of Neurology
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Member, Cancer Center, University of Pennsylvania
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Member, Basic Research Committee, Dept. Neurology, University of Pennsylvania
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Member, Center for AIDS Research, University of Pennsylvania
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Member, MD/PhD Combined Degree Admissions/Advisory Committee, University of Pennsylvania
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Department: Neurology
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Contact information
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280C Clinical Research Building
22 University of Pennsylvania
37 415 Curie Blvd.
Philadelphia, PA 19104/6146
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22 University of Pennsylvania
37 415 Curie Blvd.
Philadelphia, PA 19104/6146
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Office: 215 573-3505
32 Fax: 215 573-2029
32 Lab: 215-573-3504
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32 Fax: 215 573-2029
32 Lab: 215-573-3504
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Email:
KOLSOND@MAIL.MED.UPENN.EDU
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KOLSOND@MAIL.MED.UPENN.EDU
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Graduate Group Affiliations
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Publications
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Education:
21 9 B.S. 14 (Biology) c
47 Pennsylvania State University, magna cum laude, 1977.
21 9 M.S. 20 (Biological Sciences) c
31 University of Pittsburgh, 1980.
21 a Ph.D. 20 (Biological Sciences) c
31 University of Pittsburgh, 1984.
21 9 M.D. c
4f University of Pittsburgh School of Medicine, cum laude, 1985.
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21 9 B.S. 14 (Biology) c
47 Pennsylvania State University, magna cum laude, 1977.
21 9 M.S. 20 (Biological Sciences) c
31 University of Pittsburgh, 1980.
21 a Ph.D. 20 (Biological Sciences) c
31 University of Pittsburgh, 1984.
21 9 M.D. c
4f University of Pittsburgh School of Medicine, cum laude, 1985.
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Post-Graduate Training
24 5a Intern In Medicine, Mercy Hospital of Pittsburgh, Pittsburgh, 1985-1986.
24 66 Resident in Neurology, Duke Univ. Medical Center, Durham, North Carolina, 1986-1989.
24 57 Fellow in Neurovirology, Univ. of Penn., Philadelphia, PA, 1989-1992.
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24 5a Intern In Medicine, Mercy Hospital of Pittsburgh, Pittsburgh, 1985-1986.
24 66 Resident in Neurology, Duke Univ. Medical Center, Durham, North Carolina, 1986-1989.
24 57 Fellow in Neurovirology, Univ. of Penn., Philadelphia, PA, 1989-1992.
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Certifications
28 43 Amercian Board of Neurology and Psychiatry, 1990.
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Permanent link28 43 Amercian Board of Neurology and Psychiatry, 1990.
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75 Mechansims and determinants of HIV induced neuronal injury. Neuronal cell responses to virus induced injury.
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84 Key words: neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor.
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26 Description of Research
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28a The Kolson lab focuses the roles for inflammation, immune activation, and oxidative stress in virus-induced neurodegeneration. Major areas of focus involve immunodeficiency viruses (HIV and simian immunodeficiency virus/SIV). Research in the lab involves analysis of human brain specimens from HIV infected individuals, studies of neurodegeneration and neuroinflammation in SIV-infected Rhesus macaques, in vitro modeling of HIV-induced neurodegeneration, and oxidative stress responses in vitro and in vivo. We also study responses to HIV infection in cohorts of individuals participating in national/international clinical cohort trials.
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354 We have developed a unique in vitro model of HIV-induced neurodegeneration, and we combine this model with analyses of autopsied human brains from HIV infected individuals and SIV-infected Rhesus macaques to identify pathways of neurodegeneration and modulating effects of host antioxidant response genes. We have identified a defect in the human host anti-oxidant response to HIV infection of the brain that determines an individual's risk for neurodegeneration and neurocognitive impairment in HIV infection. This has led to a pilot proof-of-principle neuroprotection drug study in Rhesus macaques. In neurogenetic studies, we have linked a common genetic polymorphism ((GT)n dinucleotide repeat length variation) in the antioxidant gene heme oxygenase-1, to risk for neuroinflammation and neurocognitive impairment in HIV-infected persons.
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258 Dr. Kolson has had active NIH funding for his laboratory since 1992, and he has trained PhD and MD-PhD students in his lab. Several of his students have been awarded a Ruth L. Kirschtein (F30, F31) National Research Service Award (NRSA) to support their own research training. He is active in training graduate and medical students as a laboratory research mentor, and he also gives interested trainees an opportunity for exposure to translational aspects of neurovirology/neuroimmunology research by offering students an opportunity to attend his weekly multiple sclerosis outpatient clinic.
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Description of Research Expertise
2a Research Interests75 Mechansims and determinants of HIV induced neuronal injury. Neuronal cell responses to virus induced injury.
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84 Key words: neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor.
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26 Description of Research
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28a The Kolson lab focuses the roles for inflammation, immune activation, and oxidative stress in virus-induced neurodegeneration. Major areas of focus involve immunodeficiency viruses (HIV and simian immunodeficiency virus/SIV). Research in the lab involves analysis of human brain specimens from HIV infected individuals, studies of neurodegeneration and neuroinflammation in SIV-infected Rhesus macaques, in vitro modeling of HIV-induced neurodegeneration, and oxidative stress responses in vitro and in vivo. We also study responses to HIV infection in cohorts of individuals participating in national/international clinical cohort trials.
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354 We have developed a unique in vitro model of HIV-induced neurodegeneration, and we combine this model with analyses of autopsied human brains from HIV infected individuals and SIV-infected Rhesus macaques to identify pathways of neurodegeneration and modulating effects of host antioxidant response genes. We have identified a defect in the human host anti-oxidant response to HIV infection of the brain that determines an individual's risk for neurodegeneration and neurocognitive impairment in HIV infection. This has led to a pilot proof-of-principle neuroprotection drug study in Rhesus macaques. In neurogenetic studies, we have linked a common genetic polymorphism ((GT)n dinucleotide repeat length variation) in the antioxidant gene heme oxygenase-1, to risk for neuroinflammation and neurocognitive impairment in HIV-infected persons.
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258 Dr. Kolson has had active NIH funding for his laboratory since 1992, and he has trained PhD and MD-PhD students in his lab. Several of his students have been awarded a Ruth L. Kirschtein (F30, F31) National Research Service Award (NRSA) to support their own research training. He is active in training graduate and medical students as a laboratory research mentor, and he also gives interested trainees an opportunity for exposure to translational aspects of neurovirology/neuroimmunology research by offering students an opportunity to attend his weekly multiple sclerosis outpatient clinic.
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Description of Clinical Expertise
45 multiple sclerosis, neurological complication of AIDS1a 29
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13e Patel SH, Kolson DL, Glosser G, Matozzo I, Ge Y, Babb JS, Mannon LJ and Grossman RI. : Correlation between percentage of brain parenchymal volume and neurocognitive performance in HIV infected patients. Am. J. Neuroradiol. 23: 543-549, 2002.
188 Chen W, Sulcove J, Frank I, Jaffer S, Ozdener H and Kolson DL. : Development of a human neuronal cell model for HIV/macrophage-induced neurotoxicity: apoptosis induced by HIV-1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pathway. J. Virology 76: 9407-9419, 2002.
12d Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ and Kolson DL. : Age-related total gray matter and white matter changes in normal adult brain. Part I. Volumetric MR imaging analysis. Am. J. Neuroradiol. 23: 1327-1333, 2002.
14c Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ and Kolson DL. : Age-related total gray matter and white matter changes in normal adult brain. Part II: quantitative magnetization transfer ratio histogram analysis. Am. J. Neuroradiol. 23: 1334-1341, 2002.
150 O’Donnell, LA, Chen W, Agrawal A, Sulcove J and Kolson DL. : Potential neuroprotective role of APJ/apelin interactions: protection against HIV-induced apoptosis. NIMH workshop: Viral and Host Genetic Factyors Regulating HIV/CNS Disease, Rockville, MD. 2002.
e2 Martin-Garcia J, Kolson DL, Gonzalez-Scarano F. : Chemokine receptors in the brain: their role in HIV infection and pathogenesis. AIDS (in press). 2002.
11e Ge Y, Grossman RL, Udupa JK, Babb JS, Kolson DL and McGowan JC. : Magnetization transfer ratio histogram analysis of gray matter in relapsing-remitting multiple sclerosis. Am. J. Neuroradiol. 22: 470-475, 2001.
122 Ge Y, Grossman RL, Udupa JK, Babb JS, Nyul LG and Kolson DL. : Brain atrophy in relapsing-remitting multiple sclerosis: fractional volumetric analysis of gray matter and white matter. Radiology 220: 606-610, 2001.
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Selected Publications
e3 Kolson DL, Sabnekar P, Baybis M and Crino PB: Gene expression in TUNEL-positive Neurons in HIV-infected brain. J. Neurovirol. 10((suppl. 1)): 102-7, 2004.13e Patel SH, Kolson DL, Glosser G, Matozzo I, Ge Y, Babb JS, Mannon LJ and Grossman RI. : Correlation between percentage of brain parenchymal volume and neurocognitive performance in HIV infected patients. Am. J. Neuroradiol. 23: 543-549, 2002.
188 Chen W, Sulcove J, Frank I, Jaffer S, Ozdener H and Kolson DL. : Development of a human neuronal cell model for HIV/macrophage-induced neurotoxicity: apoptosis induced by HIV-1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pathway. J. Virology 76: 9407-9419, 2002.
12d Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ and Kolson DL. : Age-related total gray matter and white matter changes in normal adult brain. Part I. Volumetric MR imaging analysis. Am. J. Neuroradiol. 23: 1327-1333, 2002.
14c Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ and Kolson DL. : Age-related total gray matter and white matter changes in normal adult brain. Part II: quantitative magnetization transfer ratio histogram analysis. Am. J. Neuroradiol. 23: 1334-1341, 2002.
150 O’Donnell, LA, Chen W, Agrawal A, Sulcove J and Kolson DL. : Potential neuroprotective role of APJ/apelin interactions: protection against HIV-induced apoptosis. NIMH workshop: Viral and Host Genetic Factyors Regulating HIV/CNS Disease, Rockville, MD. 2002.
e2 Martin-Garcia J, Kolson DL, Gonzalez-Scarano F. : Chemokine receptors in the brain: their role in HIV infection and pathogenesis. AIDS (in press). 2002.
11e Ge Y, Grossman RL, Udupa JK, Babb JS, Kolson DL and McGowan JC. : Magnetization transfer ratio histogram analysis of gray matter in relapsing-remitting multiple sclerosis. Am. J. Neuroradiol. 22: 470-475, 2001.
122 Ge Y, Grossman RL, Udupa JK, Babb JS, Nyul LG and Kolson DL. : Brain atrophy in relapsing-remitting multiple sclerosis: fractional volumetric analysis of gray matter and white matter. Radiology 220: 606-610, 2001.
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