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Wesley Baker, PhD

Research Associate of Neurology
Research Associate, University of Pennsylvania
Department: Neurology

Contact information

,
Education:
BS (Physics)
Bucknell University, 2005.
PhD (Physics)
University of Pennsylvania, 2015.
Post-Graduate Training
Postdoc in Anesthesiology & Critical Care, University of Pennsylvania, 2015-2017.
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Description of Research Expertise

I am a physicist with specialization in optics in biological tissues. In 2015, I received my PhD in the Department of Physics and Astronomy at the University of Pennsylvania under the supervision of Arjun Yodh. I then completed a 2-year postdoctoral fellowship mentored by W. Andrew Kofke in the department of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania. Emergent themes from my previous work include (1) studying ischemic pathophysiology with diffuse optics, (2) formulating new analytical models/paradigms to improve the fidelity of cerebral hemodynamic data based on optical signals, and (3) devising new clinical applications for diffuse optics, such as non-invasive monitoring of cerebral perfusion pressure. As a researcher in biomedical optics, I aim to develop optical tools for clinical use. Broadly, I envision designing clinical research that furthers the prognostic utility of optical tools in the treatment of acute brain injury. I also envision harnessing cerebral hemodynamic data from optical measurements in human patients and pre-clinical animal models to illuminate etiologies of neurological injuries/disorders with the hope of establishing novel therapies (e.g., ischemic stroke, hydrocephalus).

Selected Publications

Baker Wesley B, Balu Ramani, He Lian, Busch David R, Yodh Arjun G, St. Lawrence Keith, Kofke W. Andrew: Non-invasive Optical Cerebral Blood Flow and Oxygenation Monitoring in Critically Brain-injured Patients. International Anesthesia Research Society Annual Meeting April 2018.

Baker Wesley B, Parthasarathy Ashwin B, He Lian, Kavuri Venkaiah C, Diop Mamadou, Milej Daniel, Busch David R, Gannon Kimberly P, Mullen Michael T, Detre John A, Licht Daniel J, St Lawrence Keith, Balu Ramani, Kofke W Andrew, Yodh Arjun G: Noninvasive optical monitoring of cerebral blood flow, critical closing pressure, and arteriole compliance in adult human subjects. Optical Society of America Biophotonics Congress: Biomedical Optics April 2018.

Parthasarathy Ashwin B, Gannon Kimberly P, Baker Wesley B, Favilla Christopher G, Balu Ramani, Kasner Scott E, Yodh Arjun G, Detre John A, Mullen Michael T: Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 38(2): 230-240, Feb 2018.

Busch David R, Balu R, Baker Wesley B, Guo Wensheng, He Lian, Diop Mamadou, Milej Daniel, Kavuri Venkaiah, Amendolia Olivia, St. Lawrence Keith, Yodh Arjun G, Kofke W Andrew: Detection of Brain Hypoxia Based on Non-invasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy. Neurocritical Care Page: In Press, 2018.

Baker Wesley B, Parthasarathy Ashwin B, Gannon Kimberly P, Kavuri Venkaiah C, Mullen Michael T, Busch David R, He Lian, Yodh Arjun G, Balu Ramani, Kofke W. Andrew: Non-invasive Optical Monitoring of Critical Closing Pressure in Humans. Society for Neuroscience in Anesthesiology and Critical Care Annual Meeting October 2017.

Baker Wesley B, Parthasarathy Ashwin B, Gannon Kimberly P, Kavuri Venkaiah C, Busch David R, Abramson Kenneth, He Lian, Mesquita Rickson C, Mullen Michael T, Detre John A, Greenberg Joel H, Licht Daniel J, Balu Ramani, Kofke W Andrew, Yodh Arjun G: Noninvasive optical monitoring of critical closing pressure and arteriole compliance in human subjects. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37(8): 2691-2705, Aug 2017.

Cochran J M, Chung S H, Leproux A, Baker W B, Busch D R, DeMichele A M, Tchou J, Tromberg B J, Yodh A G: Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy. Physics in medicine and biology 62(12): 4637-4653, Jun 2017.

Baker Wesley B, Li Zhe, Schenkel Steven, Chandra Malavika, Busch David R, Englund Erin K, Ratcliffe Sarah J, Yodh Arjun G, Floyd Thomas F, Mohler Emile R: Optical Measurement of the effects of exercise training on muscle oxygen metabolism and blood flow in patients with peripheral artery disease. SPIE Photonics West BIOS February 2017.

Baker Wesley B, Li Zhe, Schenkel Steven S, Chandra Malavika, Busch David R, Englund Erin K, Schmitz Kathryn H, Yodh Arjun G, Floyd Thomas F, Mohler Emile R: Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease. Journal of applied physiology (Bethesda, Md. : 1985) 123(6): 1599-1609, 12 2017.

Busch David R, Rusin Craig G, Miller-Hance Wanda, Kibler Kathy, Baker Wesley B, Heinle Jeffrey S, Fraser Charles D, Yodh Arjun G, Licht Daniel J, Brady Kenneth M: Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest. Biomedical optics express 7(9): 3461-3470, Sep 2016.

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Last updated: 06/27/2018
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