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Wesley B. Baker, PhD

Assistant Professor of Neurology
Department: Neurology

Contact information
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 8145713886
Graduate Group Affiliations
Education:
BS (Physics)
Bucknell University, 2005.
PhD (Physics)
University of Pennsylvania, 2015.
Post-Graduate Training
Postdoc in Anesthesiology & Critical Care, University of Pennsylvania, 2015-2017.
Research Associate in Neurology , Children's Hospital of Philadelphia, 2017-2020.
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Description of Research Expertise

I am a physicist with specialization in optics in biological tissues. In 2015, I received my PhD in the Department of Physics and Astronomy at the University of Pennsylvania under the supervision of Arjun Yodh. I then completed a 2-year postdoctoral fellowship mentored by W. Andrew Kofke in the department of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania. Emergent themes from my previous work include (1) studying ischemic pathophysiology with diffuse optics, (2) formulating new analytical models/paradigms to improve the fidelity of cerebral hemodynamic data based on optical signals, and (3) devising new clinical applications for diffuse optics, such as non-invasive monitoring of cerebral perfusion pressure. As a researcher in biomedical optics, I aim to develop optical tools for clinical use. Broadly, I envision designing clinical research that furthers the prognostic utility of optical tools in the treatment of acute brain injury. I also envision harnessing cerebral hemodynamic data from optical measurements in human patients and pre-clinical animal models to illuminate etiologies of neurological injuries/disorders with the hope of establishing novel therapies (e.g., ischemic stroke, hydrocephalus).

Selected Publications

Baker WB, Forti RM, Ranieri N, Hurlock AM, Goto R, Anderson D, Lynch JM, Lang S, Flanders TM, Heuer G, Ko TS, White BR: Low Frequency Power in Cerebral Blood Flow Detects Impaired Oxygen Metabolism in Neonatal Hydrocephalus. SPIE Photonics West: Clinical and Translational Neurophotonics Page: 13302-21, 2025.

Emani VS, Ozturk C, Singh M, Long C, Duffy S, Gottlieb Sen D, Roche ET, Baker WB: Finite element modeling of abdominal near-infrared spectroscopy for infant splanchnic oximetry. International Journal for Numerical Methods in Biomedical Engineering 41(4): e70035, 2025.

Baker WB, Hurlock AM, Mcintosh C, Zhao H, Davis C, Anderson D, Bayle B, Goto R, Forti RM, Ko TS, White BR, Lynch JM. Optica Biophotonics Congress Apr 2025.: Optical Monitoring Reveals Increased Intracranial Pressure After the Glenn Surgery in Children with Single-Ventricle Heart Defects. Optica Biophotonics Congress Page: BTu1B.2, 2025.

Rosenthal ZP, Majeski JB, Somarowthu A, Quinn DK, Lindquist BE, Putt ME, Karaj A, Favilla CG, Baker WB, Hosseini G, Rodriguez JP, Cristancho MA, Sheline YI, William Shuttleworth C, Abbott CC, Yodh AG, Goldberg EM. Nat Commun. 2025 May 18;16(1):4619. : Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans. Nat Commun. 18(16): 4619, 2025.

Andersen KN, Yao S, White BR, Jacobwitz M, Breimann J, Jahnavi J, Schmidt A, Baker WB, Ko TS, Gaynor JW, Vossough A, Xiao R, Licht DJ, Shih EK. J Am Heart Assoc. 2025 Feb 4;14(3):e035359.: Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes. J Am Heart Assoc 14(3): e035359, 2025.

Ko TS, Greenwood JC, Morgan RW, Abella BS, Shofer FS, Mason M, Weintraub D, Bungatavula D, Lewis A, Ranieri NR, Yodh AG, Baker WB, Forti RM, Kao SH, Shin SS, Kilbaugh TJ, Jang DH: Attenuation of mitochondrial dysfunction in a ventricular fibrillation swine model of cardiac arrest treated with carbon monoxide. Resuscitation 213: 110647, 2025.

Favilla CG, Carter S, Hartl B, Gitlevich R, Mullen MT, Yodh AG, Baker WB, Konecky S: Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver. Neurophotonics 11(1): 015008, January 2024.

Favilla CG, Forti RM, Carter S, Kofke WA, Kasner SE, Baker WB, Yodh AG, Messé SR, Cummings S, Kung DK, Burkhardt JK, Choudhri OA, Pukenas B, Srinivasan VM, Hurst RW, Detre JA: Microvascular reperfusion during endovascular therapy: the balance of supply and demand. J Neurointerv Surg. 16(11): 1108-1114, 2024.

Gaudio HA, Padmanabhan V, Landis WP, Silva LEV, Slovis J, Starr J, Weeks MK, Widmann NJ, Forti RM, Laurent GH, Ranieri NR, Mi F, Degani RE, Hallowell T, Delso N, Calkins H, Dobrzynski C, Haddad S, Kao SH, Hwang M, Shi L, Baker WB, Tsui F, Morgan RW, Kilbaugh TJ, Ko TS: A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury. Sci Rep. Page: 30710, 2024.

Silva LEV, Gaudio HA, Widmann NJ, Forti RM, Padmanabhan V, Senthil K, Slovis JC, Mavroudis CD, Lin Y, Shi L, Baker WB, Morgan RW, Kilbaugh TJ, Tsui FR, Ko TS: Amplitude spectrum area is dependent on the electrocardiogram magnitude: evaluation of different normalization approaches. Physiol Meas. 45(11), 2024.

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Last updated: 06/27/2025
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