Wesley B. Baker, PhD
Assistant Professor of Neurology
Department: Neurology
Contact information
3501 Civic Center Boulevard
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 8145713886
Email:
bakerw@chop.edu
bakerw@chop.edu
Publications
Education:
BS (Physics)
Bucknell University, 2005.
PhD (Physics)
University of Pennsylvania, 2015.
BS (Physics)
Bucknell University, 2005.
PhD (Physics)
University of Pennsylvania, 2015.
Post-Graduate Training
Postdoc in Anesthesiology & Critical Care, University of Pennsylvania, 2015-2017.
Research Associate in Neurology , Children's Hospital of Philadelphia, 2017-2020.
Permanent linkPostdoc in Anesthesiology & Critical Care, University of Pennsylvania, 2015-2017.
Research Associate in Neurology , Children's Hospital of Philadelphia, 2017-2020.
Description of Research Expertise
I am a physicist with specialization in optics in biological tissues. In 2015, I received my PhD in the Department of Physics and Astronomy at the University of Pennsylvania under the supervision of Arjun Yodh. I then completed a 2-year postdoctoral fellowship mentored by W. Andrew Kofke in the department of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania. Emergent themes from my previous work include (1) studying ischemic pathophysiology with diffuse optics, (2) formulating new analytical models/paradigms to improve the fidelity of cerebral hemodynamic data based on optical signals, and (3) devising new clinical applications for diffuse optics, such as non-invasive monitoring of cerebral perfusion pressure. As a researcher in biomedical optics, I aim to develop optical tools for clinical use. Broadly, I envision designing clinical research that furthers the prognostic utility of optical tools in the treatment of acute brain injury. I also envision harnessing cerebral hemodynamic data from optical measurements in human patients and pre-clinical animal models to illuminate etiologies of neurological injuries/disorders with the hope of establishing novel therapies (e.g., ischemic stroke, hydrocephalus).Selected Publications
Ranieri NR, Forti RM, Baker WB, Nicolson SC, Lynch JM: Monitoring Cerebral Oxygenation During Neonatal Cardiac Surgery: Limitations of Conventional NIRS. Paediatric Anaesthesia Page: 70183, April 2026.Lewis A, Forti RM, Ko TS, Greenwood JC, Kelly M, Shofer FS, Kao SH, Shin SS, Bungatavula D, Mason M, Starr J, Ehinger JK, Kilbaugh TJ, Yodh AG, Jang DH, Baker WB: Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning. Neurotoxicology 114: 103454, April 2026 Notes: Baker WB and Jang DH are co-senior authors.
Winston CN, Bowe ME, Lee S, Ranieri NR, Ades A, Gebb J, Rychik J, Naim MY, Bostwick A, Forti RM, Ko TS, Foglia EE, Baker WB, Lynch JM: Noninvasive optical monitoring of cerebral hemodynamics immediately after birth in neonates with congenital heart disease. Resuscitation Plus 28: 101272, March 2026.
Silva LEV, Gaudio HA, Padmanabhan B, Forti RM, Shi L, Mason M, Sueishi T, Kirschen MP, Baker WB, Kilbaugh TJ, Morgan RW, Tsui FR, Ko TS: Machine Learning-Based Return of Spontaneous Circulation Prediction During Cardiopulmonary Resuscitation in a Swine Model of Cardiac Arrest: Effect of Data Resolution and Multimodal Physiological Waveforms. Critical Care Medicine 54(2): 257-269, February 2026.
Lewis A, Forti RM, Ko TS, Elmer E, McManus MJ, Yodh AG, Kilbaugh TJ, Baker WB: Optical and microdialysis monitoring of succinate prodrug treatment in a rotenone-induced model of mitochondrial dysfunction in swine. Metabolites 16(65): 16010065, January 2026.
Majeski JB, Forti RM, Chong SH, Aparanji S, Zhao M, Abramson K, Ramachandran NR, Srinivasan VJ, Baker WB, Yodh AG: Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring. Neurophotonics 12(3): 035005, July 2025.
Baker WB, Forti RM, Ranieri N, Hurlock AM, Goto R, Anderson D, Lynch JM, Lang S, Flanders TM, Heuer G, Ko TS, White BR: Low Frequency Power in Cerebral Blood Flow Detects Impaired Oxygen Metabolism in Neonatal Hydrocephalus. SPIE Photonics West: Clinical and Translational Neurophotonics Page: 13302-21, 2025.
Rosenthal ZP, Majeski JB, Somarowthu A, Quinn DK, Lindquist BE, Putt ME, Karaj A, Favilla CG, Baker WB, Hosseini G, Rodriguez JP, Cristancho MA, Sheline YI, William Shuttleworth C, Abbott CC, Yodh AG, Goldberg EM. Nat Commun. 2025 May 18;16(1):4619. : Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans. Nat Commun. 18(16): 4619, 2025.
Andersen KN, Yao S, White BR, Jacobwitz M, Breimann J, Jahnavi J, Schmidt A, Baker WB, Ko TS, Gaynor JW, Vossough A, Xiao R, Licht DJ, Shih EK.: Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes. J Am Heart Assoc 14(3): e035359, 2025.
Ko TS, Greenwood JC, Morgan RW, Abella BS, Shofer FS, Mason M, Weintraub D, Bungatavula D, Lewis A, Ranieri NR, Yodh AG, Baker WB, Forti RM, Kao SH, Shin SS, Kilbaugh TJ, Jang DH: Attenuation of mitochondrial dysfunction in a ventricular fibrillation swine model of cardiac arrest treated with carbon monoxide. Resuscitation 213: 110647, 2025.
