faculty photo

Colin A Ellis, MD

Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
Department: Neurology

Contact information
University of Pennsylvania
Department of Neurology
3 West Gates Building
Philadelphia, PA 19104
Office: 215-349-5166
Fax: 215-349-5733
Education:
ScB (Cog. Neuroscience)
Brown University, 2005.
MD (Medicine)
University of Pennsylvania School of Medicine, 2012.
Post-Graduate Training
Intern in Medicine, Hospital of the University of Pennsylvania, 2012-2013.
Resident in Epilepsy, Hospital of the University of Pennsylvania, 2013-2016.
Fellow in Epilepsy, Hospital of the University of Pennsylvania, 2016-2017.
Post-Doctoral Research Fellow, University of Pennsylvania, 2017-2019.
Fellow, Epilepsy & Genetics, University of Melbourne and Austin Health Melbourne, Australia, 2017-2018.
Certifications
Diplomat - American Board of Psychiatry and Neurology , 2016.
Epilepsy Certification, American Board of Psychiatry and Neurology, 2017.
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Description of Clinical Expertise

Dr. Ellis is a neurologist with expertise in the management of seizures and epilepsy. This includes expertise in EEG, anti-seizure medications, surgical treatment of epilepsy, neurostimulation, and implantable devices. Dr. Ellis also has clinical expertise in genetics and the genetic causes of epilepsy. He sees patients with epilepsy for genetic evaluations at the University of Pennsylvania and the Children's Hospital of Philadelphia.

Description of Research Expertise

Dr. Ellis's research is focused on the genetic basis of epilepsy. He is particularly interested in the discovery of genes that cause epilepsy; the heritability of epilepsy within families; and the use of genetics to improve the diagnosis and treatment of epilepsy.

Selected Publications

Galer PD, Ganesan S, Lewis-Smith D, McKeown SE, Pendziwiat M, Helbig KL, Ellis CA, Rademacher A, Smith L, Poduri A, Seiffert S, von Spiczak S, Muhle H, van Baalen A, Thomas RH, Krause R, Weber Y, Helbig I.: Semantic Similarity Analysis Reveals Robust Gene-Disease Relationships in Developmental and Epileptic Encephalopathies. Am J Hum Genet 107(4): 683-697, Oct 2020.

Galer PD, Ganesan S, Lewis-Smith D, McKeown SE, Pendziwiat M, Helbig KL, Ellis CA, Rademacher A, Smith L, Poduri A, Seiffert S, von Spiczak S, Muhle H, van Baalen A; NCEE Study Group; EPGP Investigators; EuroEPINOMICS-RES Consortium; Genomics Research and Innovation Network, Thomas RH, Krause R, Weber Y, Helbig I.: Semantic Similarity Analysis Reveals Robust Gene-Disease Relationships in Developmental and Epileptic Encephalopathies. American Journal of Human Genetics 107(4): 683-697, Oct 2020.

Tizazu E, Ellis CA, Reichert J, Lancaster E: Low rate of glutamic acid decarboxylase 65 (GAD-65) antibodies in chronic epilepsy. Seizure 80: 38-41, Aug 2020.

Ganesan S, Galer PD, Helbig KL, McKeown SE, O'Brien M, Gonzalez AK, Felmeister AS, Khankhanian P, Ellis CA, Helbig I.: A longitudinal footprint of genetic epilepsies using automated electronic medical record interpretation. Genet Med Aug 2020.

Helbig I, Ellis CA: Personalized medicine in genetic epilepsies - possibilities, challenges, and new frontiers. Neuropharmacology 172, Aug 2020.

Lewis-Smith D, Ellis CA, Helbig I, Thomas RH.: Early-onset Genetic Epilepsies Reaching Adult Clinics. Brain 143(3): e19, Mar 2020.

Ellis CA, Berkovic SF, Epstein MP, Ottman R; Epi4K Consortium.: The "maternal effect" on epilepsy risk: Analysis of familial epilepsies and reassessment of prior evidence. Annals of Neurology 87(1): 132-138, Jan 2020.

Ellis CA, Petrovski S, Berkovic SF.: Epilepsy genetics: clinical impacts and biological insights. Lancet Neurology 19(1): 93-100, Jan 2020.

Ellis CA, Ottman R, Epstein MP, Berkovic SF.: Generalized, focal, and combined epilepsies in families: New evidence for distinct genetic factors. Epilepsia in press, in press 2020.

Leu C, Stevelink R, Smith AW, Goleva SB, Kanai M, Ferguson L, Campbell C, Kamatani Y, Okada Y, Sisodiya SM, Cavalleri GL, Koeleman BPC, Lerche H, Jehi L, Davis LK, Najm IM, Palotie A, Daly MJ, Busch RM; Epi25 Consortium, Lal D.: Polygenic burden in focal and generalized epilepsies. Brain 142(11): 3473-3481, Nov 2019.

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Last updated: 11/19/2020
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