faculty photo

Colin A Ellis, MD

Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
Assistant Professor of Neurology, University of Pennsylvania, Department of Neurology
Program Director, Epilepsy Fellowship, Department of Neurology, University of Pennsylvania
Department: Neurology

Contact information
University of Pennsylvania
Department of Neurology
3 West Gates Building
Philadelphia, PA 19104
Office: 215-349-5166
Fax: 215-349-5733
Education:
ScB (Cog. Neuroscience)
Brown University, 2005.
MD (Medicine)
University of Pennsylvania School of Medicine, 2012.
Post-Graduate Training
Intern in Medicine, Hospital of the University of Pennsylvania, 2012-2013.
Resident in Epilepsy, Hospital of the University of Pennsylvania, 2013-2016.
Fellow in Epilepsy, Hospital of the University of Pennsylvania, 2016-2017.
Fellow, Epilepsy & Genetics, University of Melbourne and Austin Health Melbourne, Australia, 2017-2018.
Post-Doctoral Research Fellow, University of Pennsylvania, 2017-2019.
Certifications
Diplomat - American Board of Psychiatry and Neurology , 2016.
Epilepsy Certification, American Board of Psychiatry and Neurology, 2017.
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Description of Clinical Expertise

Dr. Ellis is a neurologist with expertise in the management of seizures and epilepsy. This includes expertise in EEG, anti-seizure medications, surgical treatment of epilepsy, neurostimulation, and implantable devices. Dr. Ellis also has clinical expertise in genetics and the genetic causes of epilepsy. He sees patients with epilepsy for genetic evaluations at the University of Pennsylvania and the Children's Hospital of Philadelphia.

Description of Research Expertise

Dr. Ellis's research is focused on the genetic basis of epilepsy. He is particularly interested in the discovery of genes that cause epilepsy; the heritability of epilepsy within families; and the use of genetics to improve the diagnosis and treatment of epilepsy.

Selected Publications

Guo MH, Bardakjian TM, Brzozowski MR, Scherer SS, Quinn C, Elman L, Orthmann-Murphy J, Tropea TF, Ellis CA, Gonzalez-Alegre P.: Temporal trends and yield of clinical diagnostic genetic testing in adult neurology. Am J Med Genet A 185(10): 2922-2928, Oct 2021.

Galosi S, Edani BH, Martinelli S, Hansikova H, Eklund EA, Caputi C, Masuelli L, Corsten-Janssen N, Srour M, Oegema R, Bosch DGM, Ellis CA, Amlie-Wolf L, Accogli A, Atallah I, Averdunk L, Barañano KW, Bei R, Bagnasco I, Brusco A, Demarest S, Alaix AS, Di Bonaventura C, Distelmaier F, Elmslie F, Gan-Or Z, Good JM, Gripp K, Kamsteeg EJ, Macnamara E, Marcelis C, Mercier N, Peeden J, Pizzi S, Pannone L, Shinawi M, Toro C, Verbeek NE, Venkateswaran S, Wheeler PG, Zdrazilova L, Zhang R, Zorzi G, Guerrini R, Sessa WC, Lefeber D, Tartaglia M, Hamdan FF, Grabińska KA, Leuzzi V.: De novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus. Brain Aug 2021.

Crawford K, Xian J, Helbig KL, Galer PD, Parthasarathy S, Lewis-Smith D, Kaufman MC, Fitch E, Ganesan S, O'Brien M, Codoni V, Ellis CA, Conway LJ, Taylor D, Krause R, Helbig I.: Computational analysis of 10,860 phenotypic annotations in individuals with SCN2A-related disorders. Genet Med 23(7): 1263-1272, Jul 2021.

Fitzgerald MP, Kaufman MC, Massey SL, Fridinger S, Prelack M, Ellis C, Ortiz-Gonzalez X, Fried LE, DiGiovine MP; CHOP Pediatric Epilepsy Program Collaborative, Melamed S, Malcolm M, Banwell B, Stephenson D, Witzman SM, Gonzalez A, Dlugos D, Kessler SK, Goldberg EM, Abend NS, Helbig I.: Assessing seizure burden in pediatric epilepsy using an electronic medical record-based tool through a common data element approach. Epilepsia 62(7): 1617-1628, Jul 2021.

Lewis-Smith D, Galer PD, Balagura G, Kearney H, Ganesan S, Cosico M, O'Brien M, Vaidiswaran P, Krause R, Ellis CA, Thomas RH, Robinson PN, Helbig I.: Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable. Epilepsia 62(6): 1293-1305, Jun 2021.

Lewis-Smith D, Ganesan S, Galer PD, Helbig KL, McKeown SE, O'Brien M, Khankhanian P, Kaufman MC, Gonzalez AK, Felmeister AS, Krause R, Ellis CA, Helbig I.: Phenotypic homogeneity in childhood epilepsies evolves in gene-specific patterns across 3251 patient-years of clinical data. Eur J Hum Genet May 2021.

Dreier JW, Ellis CA, Berkovic SF, Cotsapas C, Ottman R, Christensen J.: Epilepsy risk in offspring of affected parents; a cohort study of the "maternal effect" in epilepsy. Ann Clin Transl Neurol 8(1), Jan 2021.

Conrad EC, Chugh N, Ganguly TM, Gugger JJ, Tizazu EF, Shinohara RT, Raghupathi R, Becker DA, Gelfand MA, Omole AT, Decker BM, Pathmanathan JS, Davis KA, Ellis CA.: Using Generalized Polyspike Train to Predict Drug-Resistant Idiopathic Generalized Epilepsy. J Clin Neurophysiol Dec 2020.

Ellis CA, Ottman R, Epstein MP, Berkovic SF; Epi4K Consortium.: Generalized, focal, and combined epilepsies in families: New evidence for distinct genetic factors. Epilepsia 61(12): 2667-2674, Dec 2020.

Kulick-Soper CV, Stein JM, Chen IH, Ellis CA, Davis KA.: Unilateral thalamic lesion mimicking genetic generalized epilepsy. Epileptic Disord 22: 836-838, Dec 2020.

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Last updated: 12/29/2021
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