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Kyra O'Brien, MD

Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
Senior Fellow, Penn Leonard Davis Institute of Health Economics
Department: Neurology

Contact information
Penn Neuroscience Center - Neurology
3400 Civic Center Blvd
2nd Floor, South Pavilion
Philadelphia, PA 19104
BS (Biology)
Yale University, 2012.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2016.
Post-Graduate Training
Intern, Internal Medicine, Hospital of the University of Pennsylvania, 2016-2017.
Resident physician, Neurology, Hospital of the University of Pennsylvania, 2017-2020.
Clinical Fellow, Cognitive Neurology, Penn Memory Center, University of Pennsylvania, 2020-2021.
American Board of Psychiatry and Neurology - Neurology, 2020.
United Council for Neurologic Subspecialties, Behavioral Neurology and Neuropsychiatry, 2022.
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Description of Clinical Expertise

Dementia, mild cognitive impairment, Alzheimer's disease, memory disorders, cognitive evaluation, dementia diagnosis, dementia care

Description of Research Expertise

Dementia care delivery, health services research

Selected Publications

Kyra O’Brien MD, Cameron Coykendall, Melanie Kleid, Kristin Harkins MPH, Nathaniel Chin MD, Justin T. Clapp PhD MPH, and Jason Karlawish MD: Determinants of Plasma Alzheimer’s Disease Biomarker Use by Primary Care Providers and Dementia Specialists. Journal of General Internal Medicine 2024 Notes: doi: 10.1007/s11606-023-08583-9. Online ahead of print.

Antonia V. Bennett PhD, Kyra O'Brien MD, Monica Moreno BS, Kerry Lanigan BS, Katie Maslow MSW, FGSA, Carolyn A. Malone MPH, Laura C. Hanson MD, MPH, Sheryl Zimmerman PhD, Jason Karlawish MD, Emily A. Largent JD, PhD, RN, María P. Aranda PhD, MSW, MPA, Ladson Hinton MD, Brenda P. Nicholson MD, Louise Phillips MD, Sam Fazio PhD, Gary Epstein-Lubow MD: Development of a Lived Experience Panel to inform the design of embedded pragmatic trials of dementia care interventions. Journal of the American Geriatrics Society October 2023.

Kyra O’Brien MD, Justin Clapp PhD MPH, Shana D. Stites PsyD MS MA, Kristin Harkins MPH, Cameron Coykendall, Melanie Kleid, Jason Karlawish MD, Emily Largent JD PhD RN : Improving hospitalizations and care transitions for people living with dementia: Lessons from the COVID-19 pandemic Poster session presented at the 2023 Annual Scientific Meeting of the American Geriatrics Society May 2023.

Kyra O’Brien MD, Cameron Coykendall, Melanie Kleid, Kristin Harkins MPH, Nathaniel Chin MD, Justin Clapp PhD, Jason Karlawish MD: Clinician perspectives on the clinical use of plasma Alzheimer’s disease biomarkers. Poster session presented at the NIA IMPACT Collaboratory 2023 Scientific Conference on embedded Pragmatic Clinical Trials (ePCTs) in Dementia April 2023.

Emily A Largent, Joshua Grill, Kyra O'Brien, David Wolk, Kristin Harkins, Jason Karlawish: Testing for Alzheimer Disease Biomarkers and Disclosing Results Across the Disease Continuum. Neurology Jan 2023 Notes: DOI:10.1212/WNL.0000000000206891.

O’Brien K, Burke R, and Karlawish, J: A Roadmap for Modifying Clinician Behavior to Improve the Detection of Cognitive Impairment. Journal of General Internal Medicine 38: 508–512, 2023.

Kyra O'Brien, Rui Feng, Frederick Sieber, Edward R. Marcantonio, Ann Tierney, Jay Magaziner, Jeffrey L. Carson, Derek Dillane, Daniel I. Sessler, Diane Menio, Sabry Ayad, Trevor Stone, Steven Papp, Eric S. Schwenk, Mitchell Marshall, J. Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A. Hoeft, Jason Karlawish, Samir Mehta, Derek J. Donegan, Annamarie Horan, Susan S. Ellenberg, Mark D. Neuman: Outcomes with spinal versus general anesthesia for patients with and without preoperative cognitive impairment: Secondary analysis of a randomized clinical trial. Alzheimer's & Dementia 2023.

O’Brien KS, Wolk D, Lee E, Das S, Wisse L, De Jager PL, Schneider JA, Bennett DA, McMillan C.: Evidence for a Longevity Genetic Locus Associated with Tau Load in PART Platform. 71st American Academy of Neurology Annual Meeting, Philadelphia, PA May 2019 Notes: poster presentation.

McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA: Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Ann Clin Transl Neurol 5(8): 927-934, Aug 2018.

Jefferson-George KS, Wolk DA, Lee EB, McMillan CT: Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimers Dement 13(9): 1048-1053, Sep 2017.

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Last updated: 02/27/2024
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