faculty photo

Ingo Helbig, M.D.

Assistant Professor of Neurology
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
3400 Civic Center Blvd.
Philadelphia, PA 19104
Graduate Group Affiliations
Education:
M.D. (Clinical Medical)
University of Heidelberg, Germany, 2005.
Post-Graduate Training
Postdoctoral Fellow-Pediatric Epileptology, Austin Hospital, Melbourne Australia, 2005-2007.
Pediatric Resident, University medical Center, Schleswig-Holstein, 2007-2012.
Neuropediatric Resident, University medical Center, Schleswig-Holstein, 2012-2014.
Child Neurology Resident, The Children's Hospital of Philadelphia, 2014-2017.
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Description of Clinical Expertise

Neurology, Neurogenetics, Epilepsy, Pediatric Neurology

Description of Research Expertise

Gene findings for epileptic encephalopathies
Group was pivotal in the discovery of GRIN2A, CHD2, KCNA2, HCN1 and DNM1.

Gene discovery in familial epilepsies

Copy number variations in common epilepsies

Building of collaborative resources, science communication

Selected Publications

Jerome Clatot, Christopher B Currin, Qiansheng Liang, Tanadet Pipatpolkai, Shavonne L Massey, Ingo Helbig, Lucie Delemotte, Tim P Vogels, Manuel Covarrubias, Ethan M Goldberg: A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proceedings of the National Academy of Sciences 121(3): e2307776121, January 2024.

Dong Li, Qin Wang, Allan Bayat, Mark R Battig, Yijing Zhou, Daniëlle GM Bosch, Gijs van Haaften, Leslie Granger, Andrea K Petersen, Luis A Pérez-Jurado, Gemma Aznar-Laín, Anushree Aneja, Miroslava Hancarova, Sarka Bendova, Martin Schwarz, Radka Kremlíková Pourová, Zdenek Sedlacek, Beth A Keena, Michael E March, Cuiping Hou, Nora O'Connor, Elizabeth J Bhoj, Margaret H Harr, Gabrielle Lemire, Kym M Boycott, Meghan C Towne, Megan Li, Mark Tarnopolsky, Lauren Brady, Michael J Parker, Hanna Faghfoury, Lea Kristin Parsley, Emanuele Agolini, Maria Lisa Dentici, Antonio Novelli, Meredith S Wright, Rachel Palmquist, Khanh Lai, Marcello Scala, Pasquale Striano, Michele Iacomino, Federico Zara, Annina Cooper, Timothy J Maarup, Melissa Byler, Robert Roger Lebel, Tugce B Balci, Raymond J Louie, Michael J Lyons, Jessica Douglas, Catherine B Nowak, Alexandra Afenjar, Juliane Hoyer, Boris Keren, Saskia M Maas, Mahdi M Motazacker, Julian A Martinez-Agosto, Ahna M Rabani, Elizabeth M McCormick, Marni Falk, Sarah M Ruggiero, Ingo Helbig, Rikke S Møller, Lino Tessarollo, Francesco Tomassoni-Ardori, Mary Ellen Palko, Tzung-Chien Hsieh, Peter M Krawitz, Mythily Ganapathi, Bruce D Gelb, Vaidehi Jobanputra, Ashley Wilson, John Greally, Sébastien Jacquemont, Khadijé Jizi, Bruel Ange-Line, Chloé Quelin, Vinod K Misra, Erika Chick, Corrado Romano, Donatella Greco, Alessia Arena, Manuela Morleo, Vincenzo Nigro, Rie Seyama, Yuri Uchiyama, Naomichi Matsumoto, Ryoji Taira, Katsuya Tashiro, Yasunari Sakai, Gökhan Yigit, Bernd Wollnik, Michael Wagner, Barbara Kutsche, Anna CE Hurst, Michelle L Thompson, Ryan J Schmidt, Linda M Randolph, Rebecca C Spillmann, Vandana Shashi, Edward J Higginbotham, Dawn Cordeiro, Amanda Carnevale, Gregory Costain, Tayyaba Khan, Benoît Funalot, Frederic Tran Mau-Them, Luis Fernandez Garcia Moya, Sixto García-Miñaúr, Matthew Osmond, Lauren Chad, Nada Quercia, Diana Carrasco, Chumei Li, Amarilis Sanchez-Valle, Meghan Kelley, Mathilde Nizon, Brynjar O Jensson, Patrick Sulem, Kari Stefansson, Svetlana Gorokhova, Tiffany Busa, Marlène Rio, Hamza Hadj Abdallah, Marion Lesieur-Sebellin, Jeanne Amiel, Véronique Pingault, Sandra Mercier, Marie Vincent, Christophe Philippe, Clemence Fatus-Fauconnier, Kathryn Friend, Rebecca K Halligan, Sunita Biswas, Jane MR Rosser, Cheryl Shoubridge, Mark A Corbett, Christopher Barnett, Jozef Gecz, Kathleen A Leppig, Anne Slavotinek, Carlo Marcelis, Rolph Pfundt, Bert BA de Vries, Marjon A van Slegtenhorst, Alice S Brooks, Benjamin Cogne, Thomas Rambaud, Zeynep Tümer, Elaine H Zackai, Naiara Akizu, Yuanquan Song, and Hakon Hakonarson: Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. The Journal of Clinical Investigation 134(1): e171235, January 2024.

Zeynep Gokce-Samar, Annalisa Vetro, Julitta De Bellescize, Tiziana Pisano, Laloe Monteiro, Noémie Penaud, Christian M Korff, Joel Fluss, Carla Marini, Elisabetta Cesaroni, Blanca Mercedes Alvarez, Damien Sanlaville, Nicolas Chatron, Alexis A Arzimanoglou, Audrey Labalme, Vishnu A Cuddapah, Sarah M Ruggiero, Francois Lecoquierre, Gael Nicolas, Guerrot Anne Marie, Axel Lebas, Herve O Testard, Katherine L Helbig, Anna Ruiz, Adeline Ngoh, Manju A Kurian, Kimberley Reid, Robert Spaull, Pascal Joset, Georgia Ramantani, Katharina Steindl, Martin Krenn, Lucia Gerstl, Silvia Vieker, Dana Craiu, Manuela Pendziwiat, Chad Haldeman-Englert, Ilya Kanivets, Irina Romanova, Deepa S Rajan, Jill A Rosenfeld, Margaret Au, Katheryn Grand, M John Jr, Arnaud Isapof, Nathalie Villeneuve, Thomas Smol, Roseline Caumes, Pia Zacher, Sonja Neuser, Sigrid Tinschert, Konrad Platzer, Tobias Bartolomaeus, Ines Mohnke, Maximilian Radtke, Rami Abou Jamra, Ingo Helbig, Floortje E Jansen, Klaas Koop, Gabrielle Rudolf, Sebastien Küry, Julien Courchet, Renzo Guerrini, Gaetan Lesca: Molecular and Phenotypic Characterization of the RORB-Related Disorder. Neurology 2024.

Julie Xian, Kim Marie Thalwitzer, Jillian McKee, Katie Rose Sullivan, Elise Brimble, Eryn Fitch, Jonathan Toib, Michael C Kaufman, Danielle deCampo, Kristin Cunningham, Samuel R Pierce, James Goss, Charlene Son Rigby, Steffen Syrbe, Michael Boland, Benjamin Prosser, Nasha Fitter, Sarah M Ruggiero, Ingo Helbig: Delineating clinical and developmental outcomes in STXBP1-related disorders. Brain 146, December 2023.

Angela T Morgan, Thomas S Scerri, Adam P Vogel, Christopher A Reid, Mara Quach, Victoria E Jackson, Chaseley McKenzie, Emma L Burrows, Mark F Bennett, Samantha J Turner, Sheena Reilly, Sarah E Horton, Susan Block, Elaina Kefalianos, Carlos Frigerio-Domingues, Eduardo Sainz, Kristin A Rigbye, Travis J Featherby, Kay L Richards, Andrew Kueh, Marco J Herold, Mark A Corbett, Jozef Gecz, Ingo Helbig, Daisy GY Thompson-Lake, Frédérique J Liégeois, Robert J Morell, Andrew Hung, Dennis Drayna, Ingrid E Scheffer, David K Wright, Melanie Bahlo, Michael S Hildebrand: Stuttering associated with a pathogenic variant in the chaperone protein cyclophilin 40. Brain 146(12): 5086-5097, December 2023.

Lauren Jeffries, Emily K Mis, Kirsty McWalter, Sandra Donkervoort, Nina N Brodsky, Jean-Marie Carpier, Weizhen Ji, Cristian Ionita, Bhaskar Roy, Jon S Morrow, Armine Darbinyan, Krishna Iyer, Ritu B Aul, Siddharth Banka, Katherine R Chao, Laura Cobbold, Stacey Cohen, Helena M Custodio, Margaret Drummond-Borg, Frances Elmslie, Erika Finanger, Bryan E Hainline, Ingo Helbig, Stacy Hewson, Ying Hu, Adam Jackson, Dragana Josifova, Monica Konstantino, Meganne E Leach, Bryan Mak, David McCormick, Elisabeth McGee, Stanley Nelson, Joanne Nguyen, Kimberly Nugent, Lucy Ortega, Howard P Goodkin, Elizabeth Roeder, Sani Roy, Katie Sapp, Dimah Saade, Sanjay M Sisodiya, Karen Stals, Shelley Towner, William Wilson, Deciphering Developmental Disorders, Maria T Acosta, Margaret Adam, David R Adams, Pankaj B Agrawal, Mercedes E Alejandro, Justin Alvey, Laura Amendola, Ashley Andrews, Euan A Ashley, Mahshid S Azamian, Carlos A Bacino, Guney Bademci, Eva Baker, Ashok Balasubramanyam, Dustin Baldridge, Jim Bale, Michael Bamshad, Deborah Barbouth, Pinar Bayrak-Toydemir, Anita Beck, Alan H Beggs, Edward Behrens, Gill Bejerano, Jimmy Bennet, Beverly Berg-Rood, Jonathan A Bernstein, Gerard T Berry, Anna Bican, Stephanie Bivona, Elizabeth Blue, John Bohnsack, Carsten Bonnenmann, Devon Bonner, Lorenzo Botto, Brenna Boyd, Lauren C Briere, Elly Brokamp, Gabrielle Brown, Elizabeth A Burke, Lindsay C Burrage, Manish J Butte, Peter Byers, William E Byrd, John Carey, Olveen Carrasquillo, Ta Chen Peter Chang, Sirisak Chanprasert, Hsiao-Tuan Chao, Gary D Clark, Terra R Coakley, Laurel A Cobban, Joy D Cogan, Matthew Coggins, F Sessions Cole, Heather A Colley, Cynthia M Cooper, William J Craigen, Andrew B Crouse, Michael Cunningham, Precilla D'Souza, Hongzheng Dai, Surendra Dasari, Mariska Davids, Jyoti G Dayal, Matthew Deardorff, Esteban C Dell'Angelica, Shweta U Dhar, Katrina Dipple, Daniel Doherty, Naghmeh Dorrani, Emilie D Douine, David D Draper, Laura Duncan, Dawn Earl, David J Eckstein, Lisa T Emrick, Christine M Eng, Cecilia Esteves, Tyra Estwick, Marni Falk, Liliana Fernandez, Carlos Ferreira, Elizabeth L Fieg, Laurie C Findley, Paul G Fisher, Brent L Fogel, Irman Forghani, Laure Fresard, William A Gahl, Ian Glass, Rena A Godfrey, Katie Golden-Grant, Alica M Goldman, David B Goldstein, Alana Grajewski, Catherine A Groden, Andrea L Gropman, Irma Gutierrez, Sihoun Hahn, Rizwan Hamid, Neil A Hanchard, Kelly Hassey, Nichole Hayes, Frances High: Biallelic CRELD1 variants cause a multisystem syndrome including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections. Genetics in Medicine 26(2): 101023, November 2023.

Michael A Gargano, Nicolas Matentzoglu, Ben Coleman, Eunice B Addo-Lartey, Anna V Anagnostopoulos, Joel Anderton, Paul Avillach, Anita M Bagley, Eduard Bakštein, James P Balhoff, Gareth Baynam, Susan M Bello, Michael Berk, Holli Bertram, Somer Bishop, Hannah Blau, David F Bodenstein, Pablo Botas, Kaan Boztug, Jolana Čady, Tiffany J Callahan, Rhiannon Cameron, Seth J Carbon, Francisco Castellanos, J Harry Caufield, Lauren E Chan, Christopher G Chute, Jaime Cruz-Rojo, Noémi Dahan-Oliel, Jon R Davids, Maud de Dieuleveult, Vinicius de Souza, Bert BA de Vries, Esther de Vries, J Raymond DePaulo, Beata Derfalvi, Ferdinand Dhombres, Claudia Diaz-Byrd, Alexander JM Dingemans, Bruno Donadille, Michael Duyzend, Reem Elfeky, Shahim Essaid, Carolina Fabrizzi, Giovanna Fico, Helen V Firth, Yun Freudenberg-Hua, Janice M Fullerton, Davera L Gabriel, Kimberly Gilmour, Jessica Giordano, Fernando S Goes, Rachel Gore Moses, Ian Green, Matthias Griese, Tudor Groza, Weihong Gu, Julia Guthrie, Benjamin Gyori, Ada Hamosh, Marc Hanauer, Kateřina Hanušová, Yongqun He, Harshad Hegde, Ingo Helbig, Kateřina Holasová, Charles Tapley Hoyt, Shangzhi Huang, Eric Hurwitz, Julius OB Jacobsen, Xiaofeng Jiang, Lisa Joseph, Kamyar Keramatian, Bryan King, Katrin Knoflach, David A Koolen, Megan L Kraus, Carlo Kroll, Maaike Kusters, Markus S Ladewig, David Lagorce, Meng-Chuan Lai, Pablo Lapunzina, Bryan Laraway, David Lewis-Smith, Xiarong Li, Caterina Lucano, Marzieh Majd, Mary L Marazita, Victor Martinez-Glez, Toby H McHenry, Melvin G McInnis, Julie A McMurry, Michaela Mihulová, Caitlin E Millett, Philip B Mitchell, Veronika Moslerová, Kenji Narutomi, Shahrzad Nematollahi, Julian Nevado, Andrew A Nierenberg, Nikola Novák Čajbiková, John I Nurnberger Jr, Soichi Ogishima, Daniel Olson, Abigail Ortiz, Harry Pachajoa, Guiomar Perez de Nanclares, Amy Peters, Tim Putman, Christina K Rapp, Ana Rath, Justin Reese, Lauren Rekerle, Angharad M Roberts, Suzy Roy, Stephan J Sanders, Catharina Schuetz, Eva C Schulte, Thomas G Schulze, Martin Schwarz, Katie Scott, Dominik Seelow, Berthold Seitz, Yiping Shen, Morgan N Similuk, Eric S Simon, Balwinder Singh, Damian Smedley, Cynthia L Smith, Jake T Smolinsky, Sarah Sperry, Elizabeth Stafford, Ray Stefancsik, Robin Steinhaus, Rebecca Strawbridge, Jagadish Chandrabose Sundaramurthi, Polina Talapova, Jair A Tenorio Castano, Pavel Tesner, Rhys H Thomas, Audrey Thurm, Marek Turnovec, Marielle E van Gijn, Nicole A Vasilevsky, Markéta Vlčková, Anita Walden, Kai Wang, Ron Wapner, James S Ware, Addo A Wiafe, Samuel A Wiafe, Lisa D Wiggins, Andrew E Williams, Chen Wu, Margot J Wyrwoll, Hui Xiong, Nefize Yalin, Yasunori Yamamoto, Lakshmi N Yatham, Anastasia K Yocum, Allan H Young, Zafer Yüksel, Peter P Zandi, Andreas Zankl, Ignacio Zarante, Miroslav Zvolský, Sabrina Toro, Leigh C Carmody, Nomi L Harris, Monica C Munoz-Torres, Daniel Danis , Christopher J Mungall, Sebastian Köhler, Melissa A Haendel, Peter N Robinson : The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Research November 2023 Notes: In Press.

Sara E Molisani, Darshana Parikh, Marissa DiGiovine, Dennis Dlugos, Mark P Fitzgerald, Lawrence Fried, Ingo Helbig, Sudha Kilaru Kessler, Pamela Pojomovsky McDonnell, Susan Melamed, Marisa S Prelack, Uzma Sharif, Sarah Tefft, Jaclyn Tencer, Stephanie Witzman, Kathy Shaw, Nicholas S Abend: A quality improvement initiative to improve folic acid supplementation counseling for adolescent females with epilepsy. Epilepsia 64(10): 2818-2826, October 2023.

Jillian M Cameron, Colin A Ellis, Samuel F Berkovic, ILAE Genetics Commission, ILAE Genetic Literacy Task Force, Piero Perucca, J Helen Cross, Holger Lerche, Alina I Esterhuizen, Iscia Lopes‐Cendes, Meng‐Han Tsai, Daniel H Lowenstein, Nigel CK Tan, Ingo Helbig, Heather C Mefford, Andreas Brunklaus, Gaetan Lesca, Elizabeth Emma Palmer, Amy McTague, Faiza Fakhfakh, Norman Delanty, Daniel H Lowenstein, Nigel CK Tan, Alina I Esterhuizen: ILAE Genetics Literacy series: Progressive myoclonus epilepsies. Epileptic Disorders 25(5): 670-680, October 2023.

Marin Jacobwitz, Caitlyn Mulvihill, Michael C Kaufman, Alexander K Gonzalez, Karla Resendiz, Conall Francoeur, Ingo Helbig, Alexis A Topjian, Nicholas S Abend: A Comparison of Ketamine and Midazolam as First-Line Anesthetic Infusions for Pediatric Status Epilepticus. Neurocritical Care Page: 1-12, October 2023 Notes: In Press.

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Last updated: 02/01/2024
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