Christopher Perrone, MD
Associate Professor of Clinical Neurology
Associate Clerkship Director, Perelman School of Medicine
Neurology Outpatient Epic Governance Chair, University of Pennsylvania
Director of Clinical Informatics, Department of Neurology, University of Pennsylvania
Department: Neurology
Contact information
3400 Spruce Street, 3 W. Gates Building
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-662-3606
Education
B.S. (Biology and Psychology)
Tufts University, Medford, MA, 2010.
M.D.
University of Massachusetts Medical School, Worcester, MA, 2014.
B.S. (Biology and Psychology)
Tufts University, Medford, MA, 2010.
M.D.
University of Massachusetts Medical School, Worcester, MA, 2014.
Post-Graduate Training
Internal Medicine Residency Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA , 2014-2015.
PGY 2-4, Neurology Residency Program, University of Pennsylvania Health System, Philadelphia, PA , 2015-2018.
PGY 5, Clinical Neuroimmunology Fellowship Program, University of Pennsylvania Health System, Philadelphia, PA , 2018-2019.
Internal Medicine Residency Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA , 2014-2015.
PGY 2-4, Neurology Residency Program, University of Pennsylvania Health System, Philadelphia, PA , 2015-2018.
PGY 5, Clinical Neuroimmunology Fellowship Program, University of Pennsylvania Health System, Philadelphia, PA , 2018-2019.
Certifications
American Board of Psychiatry and Neurology, 2018.
Permanent linkAmerican Board of Psychiatry and Neurology, 2018.
Selected Publications
Sy Hwang, Sunil Thomas, Heather Williams, Amit Bar-Or, Vishakha Sharma, Frederik Buijs, Christopher Perrone, Danielle Mowery: Same Inputs, Different EDSS: Measuring Specification Drift in Clinical Scoring Pipelines. Cold Spring Harbor Laboratory Press June 2026.Baller E, Cooper E, Bakhtiar N, Bar-Or A, Brandstadter R, Gur R, Horwath E, Jacobs D, Perrone C, Pritschet L, Roalf D, Satterthwaite T, Shinohara R, Schindler M: Age and Sex-Specific Patterns of Cognitive Performance During Midlife in People With Multiple Sclerosis. Biological Psychiatry 99(10): S271-S272, May 2026.
Shah U, Hwang S, Sharma V, Morrison A, Naydovich L, Thomas S, Williams H, Schriver E, Batugo A, Tackenberg B, Buijs F, Bar-Or A, Mowery D, Perrone CM: Defining PIRA with AI: MS disability assessment derived from a large language model. ACTRIMS February 2026.
Hwang S, Thomas S, Williams H, Hutchinson T, Schriver E, Batugo A, Bar-Or A, Sharma V, Buijs F, Perrone C, Mowery D.: Leveraging Large Language Models to Derive Multiple Sclerosis Progression Assessments from Clinical Notes: A Feasibility Study. Pac Symp Biocomput 31: 324-337, January 2026.
Hu C, Son J, McAlpine L, Walker EL, Dahl M, Song E, Ferreira Brito S, Kavak K, Onomichi K, Bar-Or A, Perrone C, Riley CS, Weinstock Guttman B, De Jager PL, Longbrake EE, Xia Z.: Long COVID in people with multiple sclerosis and related disorders: a multicenter cross-sectional study. Ann Clin Transl Neurol. 12(12): 2446-2459, December 2025.
Oh J, Smolders J, Buijs F, Federer-Gsponer J, Meyer zu Hörste G, Mamdani M, Perrone C, Mowery DL, Kühnel T, van Tulder K, Testa C, Elze MC, Pedotti R, Kaczmarek L, Sharma V, Tackenberg B, Bar-Or A, Wiendl H: Integrating multicentre data to explore rwPIRMA: Results from the INTONATE-MS consortium. ECTRIMS September 2025 Notes: Poster presentation; presented by co-author.
Cooper EC, Schindler MK, Bar-Or A, Brandstadter RB, Calkins ME, Gur R, Jacobs DA, Markowitz C, Moore T, Naydovich LR, Perrone CM, Ruparel K, Spangler BC, Troyan S, Shinohara RT, Satterthwaite TD, Baller EB: Investigating mood and cognition in people with multiple sclerosis: A prospective cross-sectional study protocol. BMJ Open 15(5), May 2025.
Baller EB, Luo AC, Schindler MK, Cooper EC, Pecsok MK, Cieslak MC, Martin ML, Bar-Or A, Elahi A, Perrone CM, Spangler BC, Satterthwaite TD, Shinohara RT: Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis. JAMA Netw Open 8(4), April 2025.
Martin ML, Robert-Fitzgerald T, Schindler MK, Perrone C, Schultz G, Lynch S, Mirkovic N, Thomas S, Elahi A, Reid D, Moore TM, Baller EB, Satterthwaite TD, Cieslak M, Covitz S, Adebimpe A, Manning A, Markowitz CE, Detre JA, Bar-Or A, Kakara M, Shinohara RT.: Impact of insurance status on MRI phenotypes in MS. Mult Scler Relat Disord 92(105919), December 2024.
Oh J, Smolders J, Buijs F, Meyer zu Hörste G, Perrone C, van den Brand J, Federer-Gsponer J, Pedotti R, Kaczmarek L, Sharma V, Heinzmann D, Tackenberg B, Bar-Or A, Wiendl H: Defining PIRA and Lack of Disease Stability in the Real-World: Interim Results. European Committee for Treatment and Research in Multiple Sclerosis November 2024 Notes: Poster presentation; presented by co-author.