Sahily Reyes-Esteves
Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
Attending Physician, Division of Vascular neurology, Department of Neurology, Hospital of the University of Pennsylvania
Department: Neurology
Contact information
3400 Spruce St
Philadelphia, PA 19104
Philadelphia, PA 19104
Graduate Group Affiliations
Education
BS
University of Puerto Rico School of Medicine, 2010.
PhD
MD Anderson/UTHealth Graduate School of Biomedical Sciences, 2017.
MD
University of Puerto Rico School of Medicine, 2018.
BS
University of Puerto Rico School of Medicine, 2010.
PhD
MD Anderson/UTHealth Graduate School of Biomedical Sciences, 2017.
MD
University of Puerto Rico School of Medicine, 2018.
Post-Graduate Training
Intern in Medicine, Hospital of the University of Pennsylvania, 2018-2019.
Resident in Neurology, Hospital of the University of Pennsylvania, 2019-2022.
Fellow in Vascular Neurology, Hospital of the University of Pennsylvania, 2022-2023.
Post-Doctoral Researcher, Brenner Bioengineering Lab, Perelman School of Medicine, University of Pennsylvania, 2023-2024.
Permanent linkIntern in Medicine, Hospital of the University of Pennsylvania, 2018-2019.
Resident in Neurology, Hospital of the University of Pennsylvania, 2019-2022.
Fellow in Vascular Neurology, Hospital of the University of Pennsylvania, 2022-2023.
Post-Doctoral Researcher, Brenner Bioengineering Lab, Perelman School of Medicine, University of Pennsylvania, 2023-2024.
Selected Publications
Marzolini N, Brysgel TV, Rahman RJ, Essien EO, Nwe SY, Wu J, Majumder A, Patel MN, Tiwari S, Espy CL, Dong F, Santos-De León SA, Shah A, Shuvaev VV, Hood ED, Chase LS, Weissman D, Katzen JB, Frank DB, Bennett ML, Marcos-Contreras OA, Myerson JW, Muzykantov VR, Reyes-Esteves S, Brenner JS.: Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. Advanced Science 2026.Sahily Reyes-Esteves, Aparajeeta Majumder, Nicolas Marzolini, Marco E Zamora, Soomin Jeong, Yufei Wang, Manthan N Patel, Carolann Espy, Tyler Ellis Papp, Awurama Akyianu, Jia Nong, Lawson Messe, Serena Omo-Lamai, Hamideh Parhiz, Jacob W Myerson, Oscar A Marcos-Contreras, Jacob S Brenner : Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage. Journal of Neuroinflammation 22(1):234, Oct 2025.
Fischer D, Reyes-Esteves S, Law C, Ford A, Schwab P, Abella BS, Schneider ALC, Kumar MA: Implementation of a specialized neuroprognostication consultation program and associated provider attitudes: A survey-based study. Resusc Plus 23, Mar 2025.
Reyes-Esteves S, Singh A, Ternes K, Mendizabal A: Approaching neuro-palliative care with historically minoritized groups in the United States: A literature review and actionable recommendations. J Neurol Sci 468: 123333, Jan 2025 Notes: DOI: 10.1016/j.jns.2024.123333.
Reyes-Esteves S, Hunter CA. : Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source. Sci Immunol. 2025.
Reyes, S.: Targeted IL-10 therapy improves outcomes in experimental intracerebral hemorrhage. Immune Modulation and Engineering Symposium, Philadelphia, PA Nov 2024 Notes: Oral Presentation.
Majumder, A. Reyes-Esteves, S., Marcos-Contreras, O. Brenner, J: Targeted IL-10 therapy improves outcomes in intracerebral hemorrhage. NanoDDS 2024, Orlando, FL Sep 2024 Notes: Poster Presentation.
Omo-Lamai S, Nong J, Savalia K, Kelley BJ, Wu J, Esteves-Reyes S, Chase LS, Muzykantov VR, Marcos-Contreras OA, Dollé JP, Smith DH, Brenner JS: Targeting of nanoparticles to the cerebral vasculature after traumatic brain injury. PLoS One 19(6): e0297451, Jun 2024.
Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA: Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke Mol Ther 32(5): 1344-1358, May 2024.
Reyes-Esteves S, George DK, Cucchiara B: Sex differences in treatment effect in neuroprotectant trials for acute ischemic stroke: A systematic review J Neurol Sci 460: 122992, May 2024 Notes: DOI: 10.1016/j.jns.2024.122992.