Michael Guo, MD, PhD
Assistant Professor of Neurology
Department: Neurology
Contact information
3400 Spruce Street
3 Gates Building
Philadelphia, PA 19104
3 Gates Building
Philadelphia, PA 19104
Graduate Group Affiliations
Education:
BS (Cellular and Molecular Biology)
University of Michigan--Ann Arbor, 2010.
PhD (Genetics and Genomics)
Harvard University, 2016.
MD
University of Florida, 2018.
BS (Cellular and Molecular Biology)
University of Michigan--Ann Arbor, 2010.
PhD (Genetics and Genomics)
Harvard University, 2016.
MD
University of Florida, 2018.
Post-Graduate Training
Intern in Internal Medicine, University of North Carolina Chapel Hill, 2018-2019.
Resident in Neurology, University of Pennsylvania, 2019-2022.
Intern in Internal Medicine, University of North Carolina Chapel Hill, 2018-2019.
Resident in Neurology, University of Pennsylvania, 2019-2022.
Certifications
American Board of Psychiatry and Neurology, 2022.
Permanent linkAmerican Board of Psychiatry and Neurology, 2022.
Description of Clinical Expertise
Alzheimer's diseasefrontotemporal dementia
neurodegeneration
neurogenetics
Description of Research Expertise
geneticshuman genetics
genomics
somatic mosaicism
complex trait genetics
Mendelian genetics
transcriptomics
Alzheimer's disease
neurodegeneration
Selected Publications
Gibson AW, Elser H, Rosso M, Cornblath EJ, Fonkeu Y, Prasad S, Rothstein A, Nasrallah IM, Wolk DA, Guo MH : Ischemic stroke associated with amyloid-related imaging abnormalities in a patient treated with lecanemab. Alzheimer's & Dementia 20(11): 8192-8197, November 2024.Baldwin A, Copeland J, Azage M, Dratch L, Johnson K, Paul RA, Amado DA, Baer M, Deik A, Elman LB, Guo M, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn CC, Tropea TF, Scherer SS, Shinohara RT, Hamilton RH, Ellis CA.: Disparities in Genetic Testing for Neurologic Disorders. Neurology 102(6): e209161, Mar 2024.
Dratch L, Bardakjian TM, Johnson K, Babaian N, Gonzalez-Alegre P, Elman L, Quinn C, Guo MH, Scherer SS, Amado DA.: The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics. Biology 13(2): 93, Feb 2024.
Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA.: Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurol 271(2): 733-747, Feb 2024.
Guo MH, Francioli LC, Stenton SL, Goodrich JK, Watts NA, Singer-Berk M, Groopman E, Darnowsky PW, Solomonson M, Baxter S; gnomAD Project Consortium; Tiao G, Neale BM, Hirschhorn JN, Rehm HL, Daly MJ, O'Donnell-Luria A, Karczewski KJ, MacArthur DG, Samocha KE.: Inferring compound heterozygosity from large-scale exome sequencing data. Nat Genet 56(1), Jan 2024.
Ho C-H, Dippel MA, McQuade MS, Mishra A, Pribitzer S, Nguyen LA, Hardy S, Chandok H, Chardon F, McDiarmid TA, DeBerg HA, Buckner JH, Shendure J, de Boer CG, Guo MH, Tewhey R, Ray JP: Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cells. BioRxiv 2024.
Lofrano-Porto A, Pereira SA, Dauber A, Bloom JC, Fontes AN, Asimow N, de Moraes OL, Araujo PAT, Abreu AP, Guo MH, De Oliveira SF, Liu H, Lee C, Kuohung W, Coelho MS, Carroll RS, Jiang R, Kaiser UB.: OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. J Clin Invest 133(23): e161701, Dec 2023.
Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins J.: Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease. medRxiv 16, Nov 2023.
Deignan JL, Gregg AR, Grody WW, Guo MH, Kearney H, Monaghan KG, Raraigh KS, Taylor J, Zepeda-Mendoza CJ, Ziats C; ACMG Board of Directors.: Updated recommendations for CFTR carrier screening: A position statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med 25(8): 100867, Aug 2023.
Guo MH, Sama P, LaBarre BA, Lokhande H, Balibalos J, Chu C, Du X, Kheradpour P, Kim CC, Oniskey T, Snyder T, Soghoian DZ, Weiner HL, Chitnis T, Patsopoulos NA.: Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets. Genome Biol 23(1): 127, Jul 2022.