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Chafic Karam, MD
44Professor of Clinical Neurology
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Neuromuscular Fellowship Director, University of Pennsylvania
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Neurology CME course director, University of Pennsylvania
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Chief, Neuromuscular Division, University of Pennsylvania
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Department: Neurology
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Contact information
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3400 Spruce St., 3 West Gates
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Office: 2156153751
30 Fax: 2153495579
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30 Fax: 2153495579
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Publications
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Links
ad Search PubMed for articles
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ad Search PubMed for articles
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Education:
21 7 MD c
2d St Joseph University, 2006.
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21 7 MD c
2d St Joseph University, 2006.
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Post-Graduate Training
24 3a Intern, Hotel Dieu de France, 2006-2007.
24 3d Intern, Mount Sinai Beth Israel, 2007-2008.
24 4c Resident in Neurology, Mount Sinai Beth Israel, 2008-2011.
24 96 Fellow in Neuromuscular Disorders, Harvard Neurology at Brigham and Women's Hospital and Massachusetts General Hospital., 2011-2012.
24 4f Fellow in Peripheral Nerve Disorders, Mayo Clinic, 2012-2013.
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24 3a Intern, Hotel Dieu de France, 2006-2007.
24 3d Intern, Mount Sinai Beth Israel, 2007-2008.
24 4c Resident in Neurology, Mount Sinai Beth Israel, 2008-2011.
24 96 Fellow in Neuromuscular Disorders, Harvard Neurology at Brigham and Women's Hospital and Massachusetts General Hospital., 2011-2012.
24 4f Fellow in Peripheral Nerve Disorders, Mayo Clinic, 2012-2013.
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Certifications
28 31 American Board of Psychiatry and Neurology, 22 Neurology Certificate No. 56979 16 , 2011.
28 30 American Board of Psychiatry and Neurology 2f Neuromuscular Medicine Certificate No. 557 16 , 2012.
28 31 United Council for Neurologic Subspecialties 30 Clinical Neuromuscular Pathology Certification 16 , 2015.
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Permanent link28 31 American Board of Psychiatry and Neurology, 22 Neurology Certificate No. 56979 16 , 2011.
28 30 American Board of Psychiatry and Neurology 2f Neuromuscular Medicine Certificate No. 557 16 , 2012.
28 31 United Council for Neurologic Subspecialties 30 Clinical Neuromuscular Pathology Certification 16 , 2015.
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Description of Clinical Expertise
2e CIDP, MMN, Amyloid Neuropathy.26 29
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14c John E. Dvorak, Sami Khella, Brian Drachman, Rebecca Row, Janice Pieretti, Hansie Mathelier, Chafic Karam: Prevalence and attribution of polyneuropathy in p.V142I (V122I) hereditary transthyretin amyloidosis. Journal of the Neurological Sciences April 2026.
1bb Joban Vaishnav, Dimitrios Bampatsias, Brian C. Boursiquot, Yevgeniy Brailovsky, Kristin Hsu, Jamie Zigterman, Rajshekhar Chakraborty, Ashutosh Wechalekar, Pablo Garcia Pavia, Ronald Witteles, Mazen Hanna, Chafic Karam, Mathew S. Maurer, and Jan M. Griffin : Disease Prognosis and Progression in Transthyretin Amyloidosis: JACC: CardioOncology State-of-the-Art Review. JACC: CardioOncology 26 8(2), April 2026.
ce Karam C.: Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy. Muscle Nerve. Page: 73(1):86-92. Jan 2026.
1da Chakraborty R, Brailovsky Y, Hanna M, Witteles R, Vaishnav J, Hoffman JE, Griffin JM, Garcia-Pavia P, Wolinsky D, Karam C, Lachmann HJ, Gertz MA, Boursiquot BC, Bampatsias D, Hsu K, Johnson PT, Zigterman JL, Kazemzadeh AC, Maurer MS, Wechalekar AD.: Prognostic Factors and Progression Biomarkers in AL Amyloidosis: Mapping Current Knowledge and Critical Gaps Blood. 2026 Mar 4:blood.2025031651. 2026.
229 Fedak RR, Ruggerie RN, Shan Y, Curvino EJ, de Sousa JF, Daniel S, Ngo-Casi M, Kamboh H, Vu T, Durmuş H, Mozaffar T, Howard JF Jr, English EP, Benson A, Duvernay MT, Singer MS, Kalayoglu MV, Brunn C, Bodansky A, Anderson MS, DeRisi JL, Garcia ST, Yu DJL, Zorn KC, Kurtoglu M, Miljković MD, Stewart CA, Jewell CM; MG-001 Study Team. : BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial. Nat Med 2026.
240 Vu T, Durmus H, Rivner M, Shroff S, Ragole T, Myers B, Pasnoor M, Small G, Karam C, Vullaganti M, Peltier A, Sahagian G, Feinberg MH, Slanksy A, Barnett-Tapia C, Siddiqi Z, Gwathmey K, Badruddoja MA, Kamboh H, Ruggerie RN, Fedak RR, Stewart CA, Kurtoglu M, Kalayoglu M, Singer M, Jewell CM, Miljkovic MD, Dimachkie M, Mozaffar T, Howard JF Jr; MG-001 Study Team.: BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial. Nat Med. 2026.
151 Blein C, Karam C, Arvin-Berod C, Gelinas D, Barrera-Sierra S, Syed HUTA, Ward C, Goyal A, Guptill J.: Real-world treatment utilization in adults with chronic inflammatory demyelinating polyneuropathy in the United States. Front Neurol. 2026 Jan 29;16:1726857 2026.
147 Singh A, Wyatt J, Théaudin M, Karam C, Kasper D, Streubel B, Frascello K, Bondue A.: Effectiveness and Utility of Genetic Testing in Establishing a Diagnosis of Hereditary Transthyretin Amyloidosis Journal of Clinical Medicine.(14(19):6821.), Sep 2025.
196 Khandelwal N, Sanchirico M, Ajibade A, Munshi K, Vu M, Engel-Nitz N, Steiger C, Anderson AJ, Karam C. : Characteristics, Treatment Patterns, Healthcare Resource Utilization, and Costs Among Patients with Multifocal Motor Neuropathy: A US Claims Database Cohort Study J Health Econ Outcomes Res. 2025 Jun 26;12(1):261-268. Jun 2025.
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Selected Publications
172 Donofrio PD, Gorson KC, Hofman E, Karam C, Kira JI, Kostera-Pruszczyk A, Léger JM, Nobile-Orazio E, Attarian S, Markov M, Tse A, De Roeck A, Lewis RA.: Diagnostic adjudication of potential participants with chronic inflammatory demyelinating polyradiculoneuropathy in the ADHERE trial of subcutaneous efgartigimod PH20 31 J Neurol Sci. Apr 2026.14c John E. Dvorak, Sami Khella, Brian Drachman, Rebecca Row, Janice Pieretti, Hansie Mathelier, Chafic Karam: Prevalence and attribution of polyneuropathy in p.V142I (V122I) hereditary transthyretin amyloidosis. Journal of the Neurological Sciences April 2026.
1bb Joban Vaishnav, Dimitrios Bampatsias, Brian C. Boursiquot, Yevgeniy Brailovsky, Kristin Hsu, Jamie Zigterman, Rajshekhar Chakraborty, Ashutosh Wechalekar, Pablo Garcia Pavia, Ronald Witteles, Mazen Hanna, Chafic Karam, Mathew S. Maurer, and Jan M. Griffin : Disease Prognosis and Progression in Transthyretin Amyloidosis: JACC: CardioOncology State-of-the-Art Review. JACC: CardioOncology 26 8(2), April 2026.
ce Karam C.: Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy. Muscle Nerve. Page: 73(1):86-92. Jan 2026.
1da Chakraborty R, Brailovsky Y, Hanna M, Witteles R, Vaishnav J, Hoffman JE, Griffin JM, Garcia-Pavia P, Wolinsky D, Karam C, Lachmann HJ, Gertz MA, Boursiquot BC, Bampatsias D, Hsu K, Johnson PT, Zigterman JL, Kazemzadeh AC, Maurer MS, Wechalekar AD.: Prognostic Factors and Progression Biomarkers in AL Amyloidosis: Mapping Current Knowledge and Critical Gaps Blood. 2026 Mar 4:blood.2025031651. 2026.
229 Fedak RR, Ruggerie RN, Shan Y, Curvino EJ, de Sousa JF, Daniel S, Ngo-Casi M, Kamboh H, Vu T, Durmuş H, Mozaffar T, Howard JF Jr, English EP, Benson A, Duvernay MT, Singer MS, Kalayoglu MV, Brunn C, Bodansky A, Anderson MS, DeRisi JL, Garcia ST, Yu DJL, Zorn KC, Kurtoglu M, Miljković MD, Stewart CA, Jewell CM; MG-001 Study Team. : BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial. Nat Med 2026.
240 Vu T, Durmus H, Rivner M, Shroff S, Ragole T, Myers B, Pasnoor M, Small G, Karam C, Vullaganti M, Peltier A, Sahagian G, Feinberg MH, Slanksy A, Barnett-Tapia C, Siddiqi Z, Gwathmey K, Badruddoja MA, Kamboh H, Ruggerie RN, Fedak RR, Stewart CA, Kurtoglu M, Kalayoglu M, Singer M, Jewell CM, Miljkovic MD, Dimachkie M, Mozaffar T, Howard JF Jr; MG-001 Study Team.: BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial. Nat Med. 2026.
151 Blein C, Karam C, Arvin-Berod C, Gelinas D, Barrera-Sierra S, Syed HUTA, Ward C, Goyal A, Guptill J.: Real-world treatment utilization in adults with chronic inflammatory demyelinating polyneuropathy in the United States. Front Neurol. 2026 Jan 29;16:1726857 2026.
147 Singh A, Wyatt J, Théaudin M, Karam C, Kasper D, Streubel B, Frascello K, Bondue A.: Effectiveness and Utility of Genetic Testing in Establishing a Diagnosis of Hereditary Transthyretin Amyloidosis Journal of Clinical Medicine.(14(19):6821.), Sep 2025.
196 Khandelwal N, Sanchirico M, Ajibade A, Munshi K, Vu M, Engel-Nitz N, Steiger C, Anderson AJ, Karam C. : Characteristics, Treatment Patterns, Healthcare Resource Utilization, and Costs Among Patients with Multifocal Motor Neuropathy: A US Claims Database Cohort Study J Health Econ Outcomes Res. 2025 Jun 26;12(1):261-268. Jun 2025.
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