Srdjan Joksimovic, PharmD, PhD
Research Assistant Professor of Neurology
Penn Research Associate, CHOP
Department: Neurology
Contact information
3615 Civic Center Blvd.
Abramson, Suite 409
Philadelphia, PA 19104-4319
Abramson, Suite 409
Philadelphia, PA 19104-4319
Email:
joksimovis@chop.edu
joksimovis@chop.edu
Education:
PharmD (Pharmacy)
School of Pharmacy University of Belgrade, 2006.
PhD (Pharmacology)
School of Pharmacy University of Belgrade, 2013.
PharmD (Pharmacy)
School of Pharmacy University of Belgrade, 2006.
PhD (Pharmacology)
School of Pharmacy University of Belgrade, 2013.
Post-Graduate Training
Postdoctoral fellow in Anesthesiology, School of Medicine University of Virginia, 2014-2016.
Permanent linkPostdoctoral fellow in Anesthesiology, School of Medicine University of Virginia, 2014-2016.
Selected Publications
Joksimovic SM, Ghodsi SM, Heinsbroek JA, Orfila JE, Busquet N, Tesic V, Valdez R, Fine-Raquet B, Jevtovic-Todorovic V, Raol YH, Herson PS, Todorovic SM: CaV3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology. Elsevier Ltd. Dec 2022.Joksimovic SM, Sampath D, Krishnan K, Covey DF, Jevtovic-Todorovic V, Raol YH, Todorovic SM.: Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats. Br J Anaesth 127(3): 435-446, Sept 2021.
Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V.: Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells 9: 2674, Dec 2020.
Raol YH, Joksimovic SM, Sampath D, Matter BA, Lam PM, Kompella UB, Todorovic SM, González MI.: The role of KCC2 in hyperexcitability of the neonatal brain. Neurosci Lett 738: 135324, Nov 2020.
Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, Tesic V, Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM.: Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci 14: 26, May 2020.
Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V.: Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain. Br J Anaesth 124(5): 603-613, May 2020.
Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM.: Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol 177(8): 1735-1753, Apr 2020.
Diana P, Joksimovic SM, Faisant A, Jevtovic-Todorovic V.: Early exposure to general anesthesia impairs social and emotional development in rats. Mol Neurobiol 57(1): 41-50, Jan 2020.
Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM.: The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol 57(1): 208-216, Jan 2020.
Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM.: Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Br J Anaesth 122(5): 643-651, May 2019.