Samuel Alperin, MD
Assistant Professor of Clinical Neurology
Co-Chair of Section of Community Neurology, CHOP
Medical Director Inpatient Neurology Consult Service, CHOP
Department: Neurology
Education
BS
Cornell University, 2011.
MD
Hofstra Northwell Medical School, 2017.
BS
Cornell University, 2011.
MD
Hofstra Northwell Medical School, 2017.
Post-Graduate Training
Child Neurology Residency, Cincinnati Children's Hospital, 2017-2022.
Child Neurology Residency, Cincinnati Children's Hospital, 2017-2022.
Certifications
ABPN, 2022.
Permanent linkABPN, 2022.
Description of Clinical Expertise
Angelman Syndrome, Dup15q Syndrome, 22q11 Deletion Syndrome, 22q11 Duplication Syndrome, Autism, ADHDORCID identifier 
0000-0003-4703-2870
Selected Publications
Kristen Craddock, Holly Dubbs, and Samuel Alperin : Examining Epilepsy Characteristics, Workup, and Treatment in a Novel Angelman Syndrome Cohort Abstract for Child Neurology Society 2026 Oct 2026Potter SN, Petzold C, Garbarini K, Forsythe AN, Jalazo E, Gable J, Zentz S, Okoniewski KC, Alperin S, Berry-Kravis E, Bird LM, Carson RP, de Wit MY, Heimer G, Le Pichon JB, Lindsey W, Lowden A, Makowski C, Marsh E, Myers KA, Nangia S, Nespeca M, Roche-Martínez A, Schleifer P, Sell E, Thibert R, Walleigh D, Moore A, Wheeler A. : Examining Epilepsy in Angelman Syndrome: Insights From Caregiver-Reported Data in the Linking Angelman and Dup15q Data for Expanded Research Database. Pediatric Neurology Jun 2026.
Giuliana Caprara, Ashley Acevedo, Ashely Quinones, Samuel Alperin, Pamela Feliciano, Juhi Pandey, and the SPARK Consortium: A Glimpse into the Autism Phenotype within Rare Genetic Syndromes: An Exploration within the SPARK Study. Poster at Insar April 2026.
Conley C, Dienes E, He XA, Chao JH, Callahan MJ, Onisei AM, Bennett EE, Stein ALS, Alperin S, Kalin J, Mukerji S, Safavi A, Diaz CD, and Cravero J: Perceived Risk of Imaging Modalities to Evaluate Developmental Delay (PRIMEDD): A Multicenter, Multispecialty Comparison. Pediatric Anesthesia Dec 2025
Ihnen SKZ, Alperin S, Capal JK, Cohen AL, Peters JM, Bebin EM, Northrup HA, Sahin M, Krueger DA; TACERN Study Group.: Accumulated seizure burden predicts neurodevelopmental outcome at 36 months of age in patients with tuberous sclerosis complex. Epilepsia Jan 2025.
Tyler M. Spivey, Donald L. Gilbert, Samuel Alperin: Neurological Conferences: A Comparison Study. Child Neurology Society 2023 October 2023.
Ihnen SK, Alperin S, Capal J, Horn P, Griffith M, Cohen A, Peters J, Warfield S, Kroeck M, Sahin M, Wu J, Bebin M, Northrup, Krueger D: Developmental Profiles in Early-Life Tuberous Sclerosis Complex (TSC). Platform Presentation at 2022 Child Neurology Society in Cincinnati October 2022.
Alperin S, Krueger DA, Franz DN, Agricola KD, Stires G, Horn PS, Capal JK.: Symptom rates and profile clustering in tuberous sclerosis complex-associated neuropsychiatric disorders (TAND). J Neurodev Disord 13: 60, Dec 2021.
Alperin, S., Krueger, D.A., & Capal J.K.: Tuberous Sclerosis-Associated Neuropsychiatric Disorders at Cincinnati Children’s Hospital. Poster presentation at CNS-ICNA 2020 Meeting(Virtual) Oct 2020.
Alperin, S., Clemens, N., Merritt, C., Statile A.M., & Mallon, D.: Implementation of a humanities in medicine curriculum for pediatric residents. Poster Presentation at Association of Pediatric Program Directors' Annual Spring Meeting, San Diego, CA Mar 2020.