University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Faculty Overview

Tomas S. Aleman, MD

faculty photo
Associate Professor of Ophthalmology at the Hospital of the University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
Office: 215-614-4100
Fax: 215-615-0527
B.S. (Sciences (High Honors))
F. Engels Vocational Schools, 1982.
M.D. (Medicine)
University of Havana (High Honors), 1988.
Post-Graduate Training
Transitional Internship, Hospital Salvador Allende, Havana, Cuba, 1987-1988.
Junior Resident Medical Officer, Solwezi General Hospital, Republic of Zambia, 1988-1990.
Resident in Family Medicine, Policlinico Turcios Lima, Havana, Cuba., 1990-1991.
Resident in Ophthalmology, Hospital Salvador Allende, Havana, Cuba, 1991-1994.
Postdoctoctoral training in Hereditary Retinal Degenerations, Center for Hereditary Retinal Degenerations, Bascom Palmer Eye Institute, University of Miami, 1995-1995.
Research Fellow, Center for Hereditary Retinal Degenerations, Scheie Eye Institute, University of Pennsylvania, 1997-1999.
Internship in Internal Medicine, Brookdale University Hospital, New York, NY, 2010-2011.
Resident in Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 2011-2014.
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Description of Research Expertise

Dr. Aleman has extensive expertise in the study of hereditary retinal degenerations. He is part of the Retinal Degeneration Center at Scheie Eye Institute and the CAROT center of the Department of Ophthalmology of the University of Pennsylvania. His research expertise includes state-of-the-art psychophysical, electrophysiological and imaging studies in patients and animal models of the human disease. Most of the studies in which Dr. Aleman is an investigator are aimed to lead patients with these incurable retinal degenerations into clinical trials as well as in the detailed characterization of patients, both children and adults, with these conditions.

Clinical Trials
Dr. Aleman is a co-principal investigator in an ongoing gene therapy trial for choroideremia.

Key Words
Hereditary Retinal Degenerations, retinitis pigmentosa, choroideremia, cone rod dystrophy, optical coherence tomography, electroretinogram

Description of Clinical Expertise

Dr. Aleman cares for children and adults with retinal degenerations, hereditary or acquired, at Scheie Eye Institute and at the Perelman Center for Advanced Medicine. He is also a staff physician at Puentes Clinic. He is the co-principal investigator of a gene therapy trial for choroideremia. He is also responsible for all clinical electrophysiological investigations within this department, which provides this service to a large number of specialists in the region.

Description of Other Expertise

Fluent in Spanish

Selected Publications

Garnai, Sarah J; Brinkmeier, Michelle L; Emery, Ben; Aleman, Tomas S; Pyle, Louise C; Veleva-Rotse, Biliana; Sisk, Robert A; Rozsa, Frank W; Ozel, Ayse Bilge; Li, Jun Z; Moroi, Sayoko E; Archer, Steven M; Lin, Cheng-Mao; Sheskey, Sarah; Wiinikka-Buesser, Laurel; Eadie, James; Urquhart, Jill E; Black, Graeme C M; Othman, Mohammad I; Boehnke, Michael; Sullivan, Scot A; Skuta, Gregory L; Pawar, Hemant S; Katz, Alexander E; Huryn, Laryssa A; Hufnagel, Robert B; Genomic Ascertainment Cohort; Camper, Sally A; Richards, Julia E; Prasov, Lev.: Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice. PLoS Genetics 15(5): e1008130, May 2019.

Bryant Laura, Lozynska Olga, Marsh Anson, Papp Tyler E, van Gorder Lucas, Serrano Leona W, Gai Xiaowu, Maguire Albert M, Aleman Tomas S, Bennett Jean: Identification of a novel pathogenic missense mutation in using whole exome sequencing: a case report. The British journal of ophthalmology Jul 2018.

Silson Edward H, Aleman Tomas S, Willett Aimee, Serrano Leona W, Pearson Denise J, Rauschecker Andreas M, Maguire Albert M, Baker Chris I, Bennett Jean, Ashtari Manzar: Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia. Investigative ophthalmology & visual science 59(8): 3249-3258, Jul 2018.

Song Ji Yun, Aravand Puya, Nikonov Sergei, Leo Lanfranco, Lyubarsky Arkady, Bennicelli Jeannette L, Pan Jieyan, Wei Zhangyong, Shpylchak Ivan, Herrera Pamela, Bennett Daniel J, Commins Nicoletta, Maguire Albert M, Pham Jennifer, den Hollander Anneke I, Cremers Frans P M, Koenekoop Robert K, Roepman Ronald, Nishina Patsy, Zhou Shangzhen, Pan Wei, Ying Gui-Shuang, Aleman Tomas S, de Melo Jimmy, McNamara Ilan, Sun Junwei, Mills Jason, Bennett Jean: Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness. Molecular therapy : the journal of the American Society of Gene Therapy 26(6): 1581-1593, Jun 2018.

Sulewski Michael E, Serrano Leona W, Han Grace, Aleman Tomas S, Nichols Charles W: Structural and Electrophysiologic Outcomes in a Patient with Retinal Metallosis. Ophthalmology. Retina 2(2): 173-175, Feb 2018.

Nti Akosua A, Serrano Leona W, Sandhu Harpal S, Uyhazi Katherine E, Edelstein Ilaina D, Zhou Elaine J, Bowman Scott, Song Delu, Gangadhar Tara C, Schuchter Lynn M, Mitnick Sheryl, Huang Alexander, Nichols Charles W, Amaravadi Ravi K, Kim Benjamin J, Aleman Tomas S: FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA: Preliminary Results From a Phase I/II Clinical Treatment Trial. Retina (Philadelphia, Pa.) Jan 2018.

Bryant Laura, Lozynska Olga, Han Grace, Morgan Jessica I W, Gai Xiaowu, Maguire Albert M, Aleman Tomas, Bennett Jean: On variants and disease-causing mutations: Case studies of a SEMA4A variant identified in inherited blindness. Ophthalmic genetics 39(1): 144-146, Jan-Feb 2018.

Bryant Laura, Lozynska Olga, Maguire Albert M, Aleman Tomas S, Bennett Jean: Prescreening whole exome sequencing results from patients with retinal degeneration for variants in genes associated with retinal degeneration. Clinical ophthalmology (Auckland, N.Z.) 12: 49-63, 2018.

Kim Benjamin J, Irwin David J, Song Delu, Daniel Ebenezer, Leveque Jennifer D, Raquib Aaishah R, Pan Wei, Ying Gui-Shuang, Aleman Tomas S, Dunaief Joshua L, Grossman Murray: Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration. Neurology 89(15): 1604-1611, Oct 2017.

Aleman Tomas S, Ventura Camila V, Cavalcanti Milena M, Serrano Leona W, Traband Anastasia, Nti Akosua A, Gois Adriana L, Bravo-Filho Vasco, Martins Thayze T, Nichols Charles W, Maia Mauricio, Belfort Rubens: Quantitative Assessment of Microstructural Changes of the Retina in Infants With Congenital Zika Syndrome. JAMA ophthalmology 135(10): 1069-1076, Oct 2017.

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Last updated: 07/23/2020
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