Tomas S. Aleman, MD
Irene Heinz-Given and John LaPorte Research Professor
Attending Physician, Department of Ophthalmology, Hospital of the University of Pennsylvania
Director of the Retinal Structure and Function Laboratory, Perelman Center for Advanced Medicine, Perelman School of Medicine, University of Pennsylvania
Co-Director Center for Hereditary Retinal Degenerations, Scheie Eye Institute
Department: Ophthalmology
Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
51 North 39th Street
Philadelphia, PA 19104
Office: 215-614-4100
Fax: 215-615-0527
Fax: 215-615-0527
Publications
Education:
B.S. (Sciences - High Honors)
F. Engels Vocational Schools, 1982.
M.D. (Medicine)
University of Havana (High Honors), 1988.
B.S. (Sciences - High Honors)
F. Engels Vocational Schools, 1982.
M.D. (Medicine)
University of Havana (High Honors), 1988.
Post-Graduate Training
Transitional Internship, Hospital Salvador Allende, Havana, Cuba, 1987-1988.
Junior Resident Medical Officer, Solwezi General Hospital, Republic of Zambia, 1988-1990.
Resident in Family Medicine, Policlinico Turcios Lima, Havana, Cuba., 1990-1991.
Resident in Ophthalmology, Hospital Salvador Allende, Havana, Cuba, 1991-1994.
Postdoctoctoral training in Hereditary Retinal Degenerations, Bascom Palmer Eye Institute, University of Miami, 1995-1997.
Research Fellow, Center for Hereditary Retinal Degenerations, Scheie Eye Institute, University of Pennsylvania, 1997-1999.
Internship in Internal Medicine, Brookdale University Hospital, New York, NY, 2010-2011.
Resident in Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 2011-2014.
Fellowship in Medical Retina, Scheie Eye Institute, University of Pennsylvania, 2014-2015.
Transitional Internship, Hospital Salvador Allende, Havana, Cuba, 1987-1988.
Junior Resident Medical Officer, Solwezi General Hospital, Republic of Zambia, 1988-1990.
Resident in Family Medicine, Policlinico Turcios Lima, Havana, Cuba., 1990-1991.
Resident in Ophthalmology, Hospital Salvador Allende, Havana, Cuba, 1991-1994.
Postdoctoctoral training in Hereditary Retinal Degenerations, Bascom Palmer Eye Institute, University of Miami, 1995-1997.
Research Fellow, Center for Hereditary Retinal Degenerations, Scheie Eye Institute, University of Pennsylvania, 1997-1999.
Internship in Internal Medicine, Brookdale University Hospital, New York, NY, 2010-2011.
Resident in Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 2011-2014.
Fellowship in Medical Retina, Scheie Eye Institute, University of Pennsylvania, 2014-2015.
Certifications
Instituto Superior de Ciencias Medicas de la Havana, Havana, Cuba, 1994.
American Board of Ophthalmology, 2019.
Permanent linkInstituto Superior de Ciencias Medicas de la Havana, Havana, Cuba, 1994.
American Board of Ophthalmology, 2019.
Description of Research Expertise
Dr. Aleman has extensive expertise in the study of hereditary retinal degenerations. He is part of the Retinal Degeneration Center at Scheie Eye Institute and the CAROT center of the Department of Ophthalmology of the University of Pennsylvania. His research expertise includes state-of-the-art psychophysical, electrophysiological and imaging studies in patients and animal models of the human disease. Most of the studies in which Dr. Aleman is an investigator are aimed to lead patients with these incurable retinal degenerations into clinical trials as well as in the detailed characterization of patients, both children and adults, with these conditions.Clinical Trials
Dr. Aleman is a co-principal investigator in an ongoing gene therapy trial for choroideremia.
Key Words
Hereditary Retinal Degenerations, retinitis pigmentosa, choroideremia, cone rod dystrophy, optical coherence tomography, electroretinogram
Description of Clinical Expertise
Dr. Aleman cares for children and adults with retinal degenerations, hereditary or acquired, at Scheie Eye Institute and at the Perelman Center for Advanced Medicine. He is also a staff physician at Puentes Clinic. He is the co-principal investigator of a gene therapy trial for choroideremia. He is also responsible for all clinical electrophysiological investigations within this department, which provides this service to a large number of specialists in the region.Description of Other Expertise
Fluent in SpanishSelected Publications
Pierce EA, Aleman TS, Jayasundera KT, Ashimatey BS, Kim K, Rashid A, Jaskolka MC, Myers RL, Lam BL, Bailey ST, Comander JI, Lauer AK, Maguire AM, Pennesi ME.: Gene Editing for CEP290-Associated Retinal Degeneration. N Engl J Med May 2024.Wynne N, Jiang YY, Aleman TS, Morgan JIW.: FOVEAL PHENOTYPES IN CHOROIDEREMIA ON ADAPTIVE OPTICS SCANNING LIGHT OPHTHALMOSCOPY. Retina 44: 659-668, Apr 2024.
Aung MH, Aleman TS, Garcia AS, McGeehan B, Ying GS, Avery RA.: Stimulus type and duration affect magnitude and evolution of flicker-induced hyperemia measured by laser speckle flowgraphy at the optic disc and peripapillary vessels. Sci Rep 14: 6659, Mar 2024.
Wu V, Swider M, Sumaroka A, Dufour VL, Vance JE, Aleman TS, Aguirre GD, Beltran WA, Cideciyan AV.: Retinal response to light exposure in BEST1-mutant dogs evaluated with ultra-high resolution OCT. Vision Research Mar 2024.
Lam BL, Pennesi ME, Kay CN, Panda S, Gow JA, Zhao G, MacLaren RE; XIRIUS Study Group.: Assessment of Visual Function with Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa in the Randomized XIRIUS Phase 2/3 Study. Ophthalmology Feb 2024.
Kim B, Daniel E, Aleman TS, Cousins KAQ, Iacobucci E, Yu Y, Ying G-S, Irwin D: Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s Disease. Invest. Ophthalmol. Vis. Sci. Invest. Ophthalmol. Vis. Sci. Page: 1375, 2024.
Bedoukian E, Bennett J, Uyhazi KE, Maguire AM, O'Neil E, Krauss E, Roman AJ, Sumaroka A, Swider M, Scoles D, Garafalo AV, Cideciyan AV, Aleman TS: Treatment potential of RPGRIP1-associated inherited retinal degenerations. Invest. Ophthalmol. Vis. Sci. Page: 2209, 2024.
Cideciyan AV, Li RTH, Roman AJ, Sumaroka A, Stanton CM, Swider M, Garafalo AV, Heon E, Vincent A, Wright AF, Megaw R, Aleman TS, Browning AC, Dhillon B: Early-onset sub-RPE deposits in late-onset retinal degeneration (L-ORD)caused by the c.489C>G (p.S163R) founder variant in C1QTNF5. Invest. Ophthalmol. Vis. Sci. Page: 1385, 2024.
Wynne N, Jiang Y, Aleman TS, Morgan JIW: Retinal sensitivity in comparison to cone density in choroideremia. Invest. Ophthalmol. Vis. Sci. Page: 4946, 2024.
1. Aleman TS, Cideciyan AV, Weber ML, Santos A, Uyhazi KE, Parchinski K, Chung W, Margaritis P, Sun J, Scoles D, Garafalo AV, Jayagopal A, Yerxa BR, Tuller S, Maguire AM, Bennett J: AAV8-hLCA5 subretinal delivery to the macula in LCA5-associated Leber Congenital Amaurosis (LCA5-LCA): Preliminary safety and efficacy results of an ongoing phase I/II gene therapy trial. Invest. Ophthalmol. Vis. Sci. Page: 3288, 2024.