University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Faculty Overview

Richard A. Stone, MD

faculty photo
William C. Frayer Professor of Ophthalmology
Attending, Hospital of the University of Pennsylvania, Hospital of the University of Pennsylvania
Attending, Philadelphia Veterans Administration Hospital, Philadelphia Veterans Administration Hospital
Attending, Scheie Eye Institute, Glaucoma Service, Penn Presbyterian Medical Center, Scheie Eye Institute, Glaucoma Service, Penn Presbyterian Medical Center
Department: Ophthalmology

Contact information
125 John Morgan Building
University of Pennsylvania School of Medicine
Philadelphia, PA 19104
A.B. (Chemistry)
Harvard College (summa cum laude), 1968.
Columbia University College of Physicians and Surgeons, 1972.
Post-Graduate Training
Intern, Internal Medicine, Hospital of the University of Pennsylvania, 1972-1973.
Resident, Ophthalmology, Barnes Hospital, St. Louis, MO, 1973-1976.
Clinical Associate, National Eye Institute, National Institutes of Health, Bethesda, MD, 1976-1978.
American Board of Ophthalmology, 1977.
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Description of Research Expertise

Dr. Stone has extensive experience in basic and translational ophthalmology research. His laboratory applies pharmacologic, histologic and molecular biology techniques to the eye, addressing problems in ocular physiology and eye development. His research provided many of the initial descriptions of neuropeptides in the eye and in associated cranial ganglia; and with collaborators, he has contributed to the understanding of mechanisms controlling intraocular pressure. His laboratory provided the initial descriptions of the subtypes of retinal neurons involved in regulating post-natal eye growth and their potential roles in emmetropization and in the pathogenesis of myopia (i.e., nearsightedness); and he has undertaken many pharmacologic initiatives designed to understand and/or correct experimental refractive errors. Most recently, his work has implicated the endogenous retinal clock and circadian mechanisms in the control of eye growth and in the etiology of refractive errors.

Dr. Stone’s translational research previously involved glaucoma. Most recently, he has stimulated many initiatives to move laboratory research in refractive development to the clinic. This research has included analyses of novel risk factors and the initial demonstrations of diurnal oscillations of the dimensions of the human eye. In addition, he has interfaced with computer vision engineers to advance clinical ophthalmic diagnosis, principally in glaucoma, and more recently in retinopathy of prematurity (ROP) with CHOP (Children’s Hospital of Philadelphia) colleagues. Many of Dr. Stone’s findings have led to industry initiatives for clinical development.

Key Words

Ocular development, refractive errors, glaucoma, ocular pharmacology, molecular biology, histology, ocular imaging.

Description of Clinical Expertise

Dr. Stone cared for patients with glaucoma and related eye diseases for many years at the Scheie Eye Institute. Recently, he stopped providing direct clinical care.

Selected Publications

Stone RA: The nervous system and intraocular pressure. The Glaucomas, Chapter 17. Ritch R, Shields MB and Krupin T (eds.). Edition 2: 357-383, 1996.

Wilson LB, Quinn GE, Ying G-s, Francis EF, Schmid G, Lam A, Orlow J and Stone RA : The relation of axial length and intraocular pressure fluctuations in human eyes. Invest Ophthalmol Vis Sci 47: 1778-1784, May 2006.

Stone RA, Wilson LB, Ying GS, Liu C, Criss JS, Orlow J, Lindstrom JM, Quinn GE: Associations between childhood refraction and parental smoking Invest Ophthalmol Vis Sci 47(10): 4277-87, Oct 2006.

Brown JS, Flitcroft DI, Ying GS, Francis EL, Schmid GF, Quinn GE, Stone RA: In vivo human choroidal thickness measurements: evidence for diurnal fluctuations. Invest Ophthalmol Vis Sci 50(1): 5-12, Jan 2009.

Stone RA, Ying GS, Pearson DJ, Bansal M, Puri M, Miller Ey, Alexander J, Piltz-Seymour J, Nyberg W, Maguire MG, Eledath J, Sawhney H: Utility of digital stereo images for optic disc evaluation. Invest Ophthalmol Vis Sci 51(11): 5667-74, Nov 2010.

Stone RA, Khurana TS: Gene profiling in experimental models of eye growth: clues to myopia pathogenesis. Vision Res 50(23): 2322-33, Nov 2010.

Stone RA, Pardue MT, Iuvone PM, Khurana TS: Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms. Exp Eye Res 114: 35-47, Sep 2013.

Bansal M, Sizintsev M, Eledath J, Sawhney H, Pearson DJ, Stone RA: 3D Optic Disc Reconstruction via a Global Fundus Stereo Algorithm Conf Proc IEEE Eng Med Biol Soc Page: 5877-82, July 2013 Notes:

Wang L, Kallem V, Bansal M, Eledath J, Sawhney H, Karp K, Pearson DJ, Mills MD, Quinn GE, Stone RA: Interactive retinal vessel extraction by integrating vessel tracing and graph search. Med Image Comput Assist Interv 16(Pt 2): 567-74, Sep 2013 Notes: Conference Presentation.

Wang L, Kallem V, Bansal M, Eledath J, Sawhney H, Pearson DJ, Stone RA: Automatic 3D Change Detection for Glaucoma Diagnosis. IEEE App Com Vis (WACV) Page: 401-8, March 2014 Notes:

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Last updated: 07/13/2021
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