Lou J. Soslowsky - Faculty Biosketch

Lou J. Soslowsky, Ph.D.

Fairhill Professor

Director of Orthopaedic Research, University of Pennsylvania

Director of Basic Science Research, Shoulder and Elbow Service, University of Pennsylvania

Vice Chair for Research, Department of Orthopaedic Surgery, University of Pennsylvania (reappointed 2009, 2024)

Fellow, Institute of Aging, University of Pennsylvania

Founding Director, Penn Center for Musculoskeletal Disorders, University of Pennsylvania (Type 1 center designation in 2008)

Executive Committee, University of Pennsylvania, Department of Bioengineering

Executive Committee, Department of Bioengineering, University of Pennsylvania

Associate Dean for Research Integration, University of Pennsylvania, Perelman School of Medicine

Department: Orthopaedic Surgery

Contact information

McKay Orthopaedic Research Laboratory
307A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081

Office: 215-898-8654
Fax: 215-573-2133

Email:
soslowsk@upenn.edu

Graduate Group Affiliations

Bioengineering

Publications

Search PubMed for articles

Links
Search PubMed for articles
McKay Orthopaedic Research Laboratory
Lou Soslowsky Lab Homepage
Penn Center for Musculoskeletal Disorders

Education
Diploma
East Brunswick High School , 1982.
B.S. (Engineering Mechanics)
Columbia University, 1986.
M.S. (Engineering Mechanics)
Columbia University, 1987.
M.Phil
Columbia University, 1989.
Ph.D. (Engineering Mech./Biomechanics, Mentor: Van C. Mow)
Columbia University, 1991.
Cert. (Academic Medicine Leadership Program)
Wharton School of the University of Pennsylvania , 2008.

Post-Graduate Training
Research Assistant, Bioengineering Institute, Columbia University (Richard Skalak, Advisor), 1983-1986.
Teaching Assistant, Department of Mathematics, Columbia University (David Bayer, Professor), 1984-1985.
Frank E. Stinchfield Research Fellow, Departments of Mechanical Engineering and Orthopaedic Surgery, Columbia University (Van C. Mow, Advisor), 1986-1991.

Certifications
NA, .

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

orthopaedic research, orthopaedic biomechanics and tissue engineering, tendons and ligaments, shoulder and elbow

Selected Publications

Tamburro MK, Carlson JA, Yen WK, Weiss SN, Kroll EE, Doro MK, Nuss CA, Chen M, Stewart DC, Eekhoff JD, Soslowsky LJ, Volk SW: Loss of type III collagen has limited effect on tendon healing in young adult mice. Matrix Biol. 146, Jun 2026.

Taylor BL, Leiphart RJ, DiStefano MS, Weiss SN, Broadaway HB, Soslowsky LJ: Stage-Specific Collagen V Knockdown Reveals Temporal Control of Fibrillogenesis, Remodeling, and Mechanics in Tendon Healing. Int J Mol Sci 27(10): 4551, May 2026.

Carlson JA, Yen W, Weiss SN, Volk SW, Soslowsky LJ: Collagen III Deficiency Following Injury in Female Murine Tendons Alters Matrix Composition, Structure, Organization and Function. J Orthop Res 44(6): e70227, May 2026.

DiStefano MS, Eekhoff JD, Weiss SN, Nuss CA, Betts RL, Kuntz AF, Soslowsky LJ : Developmental, but not Homeostatic, Collagen V Expression Regulates Mature Murine Supraspinatus Tendon Structure, Function, and Gene Expression. J Orthop Res. 44(2), Feb 2026.

DiStefano MS, Eekhoff JD, Weiss SN, Nuss CA, Betts RL, Kuntz AF, Soslowsky LJ : Murine Supraspinatus Tendons Demonstrate Aging-Related Changes in Multiscale Mechanics, Structure, and Gene Expression. J Orthop Res. 44(1): e70013, Jan 2026.

Leiphart RJ, Weiss SN, Dyment NA, Soslowsky LJ: Regional FDL tendon properties are regulated by biglycan in a collagen VI-independent manner. Matrix Biol Plus. 6(29): 100190, 2026.

DiStefano MS, Betts RL, Nuss CA, Chenna SS, Soslowsky LJ : Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development. Ann Biomed Eng 2026 Notes: Epub ahead of print.

Leiphart RJ, Eekhoff JD, Weiss SN, Betts R, Carlson JA, Paglia-Garcés PL, Dyment NA, Birk DE, Soslowsky LJ: Collagen V Influences Homeostatic Maintenance of Patellar Tendon Failure Properties in Mature Female Mice. J Orthop Res 44(1): e70054, 2026.

Eekhoff JD, Soslowsky LJ : Statistical nonParametric Mapping Enables Rigorous Comparison of Collagen Fibril Diameter Distributions. Ann Biomed Eng. 2026 Notes: Epub ahead of print.

Blank JL, Eekhoff JD, Soslowsky LJ : Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons. J Physiol. 603(23): 7589-7601, Dec 2025.