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Annamarie D. Horan, MPA, PhD

Adjunct Assistant Professor of Orthopaedic Surgery
Director, Clinical Research, University of Pennsylvania, Department of Orthopaedic Surgery
Director, Clinical Research, University of Pennsylvania, Department of Anesthesiology & Critical Care
Department: Orthopaedic Surgery

Contact information
University of Pennsylvania
Department of Orthopaedic Surgery
3737 Market Street
Room 6113
Philadelphia, PA 19104
Office: 215-294-9132
Fax: 215-222-8859
Lab: 215-847-0132
BS (Biology)
St. Joseph's University, Philadelphia, PA, 1987.
PhD (Pathology/Radiation Oncology)
University of Pennsylvania, 2000.
MPA (Master of Public Administration)
Fels Institute of Government, University of Pennsylvania, 2011.
Post-Graduate Training
NSRA Post-Doctoral Fellow, University of Pennsylvania, School of Medicine, Department of Radiation Oncology, Philadelphia, PA, 2000-2001.
Clinical Research Coordinator Certification, University of Pennsylvania Office of Human Research (2005 - Present) , 2005.
Certified Clinical Research Coordinator (CCRC)(ACRP) FDA-C-0907-711 (2007-Present) , 2007.
Business Essentials Certification, Wharton School, University of Pennsylvania, Philadelphia, PA , 2007.
Six Sigma Master Blackbelt (LSSMB), Villanova University, Villanova, PA, 2008.
NIH Office of Human Subjects Research, "Protecting Human Research Participants", Certificate Number 24550, 2008.
Lean Certification, Villanova University, Villanova, PA, 2008.
Six Sigma Green Belt (SSGB), Villanova University, Villanova, PA, 2008.
Certified Principal Investigator (CPI)(ACRP) (2015 - Present), 2015.
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Description of Research Expertise

Clinical Trials:
-FDA CFR and ICH Guidelines
-Site preparation & Selection
-IRB submissions & maintenance
-Regulatory Document preparation & Maintenance
-CRF design & completion
-Statistical Analysis
-Study Design
-Manuscript preparation
-Project Management

Wet Lab:
-siRNA Assays
-Tissue culture
-Western Blots & Analysis
-HPLC with fluorecence or electrochemical detection
-Multiple other techniques too numerous to list

Selected Publications

Bartow-McKenney C, Hannigan GD, Horwinski J, Hesketh P, Horan AD, Mehta S, Grice EA: The microbiota of traumatic, open fracture wounds is associated with mechanism of injury. Wound Repair Regen 26(2): 127-135, Mar 2018.

Baldwin DA, Horan AD, Hesketh PJ, Mehta S: Combined RT-qPCR of mRNA and microRNA Targets within One Fluidigm Integrated Fluidic Circuit. J Biomol Tech 27(2): 75-83, Jul 2016.

Hannigan GD, Hodkinson BP, McGinnis K, Tyldsley AS, Anari JB, Horan AD, Grice EA, Mehta S. : Culture-independent pilot study of microbiota colonizing open fractures and association with severity, mechanism, location, and complication from presentation to early outpatient follow-up. J Orthop Res 32(4): 597-605, 2014.

Mark DG, Hayden GE, Ku B, Paszczuk A, Matthews S, Pugh M, Horan A, Gracias VH, Kirkpatrick JN, Dean AJ: Hand-carried echocardiography for assessment of left ventricular filling and ejection fraction in the surgical intensive care unit. J Crit Care 24(3): 470.e1-7, Sep 2009.

Tinti MS, Haut ER, Horan AD, Sonnad S, Reilly PM, Schwab CW, Gracias VH: Transition to a semiclosed surgical intensive care unit (SICU) leads to improved resident job satisfaction: a prospective, longitudinal analysis. J Surg Educ 66(1): 25-30, Jan-Feb 2009.

Gracias VH, Sicoutris CP, Stawicki SP, Meredith DM, Horan AD, Gupta R, Haut ER, Auerbach S, Sonnad S, Hanson, CW 3rd, Schwab CW: Critical care nurse practitioners improve compliance with clinical practice guidelines in "semiclosed" surgical intensive care unit. J Nurs Care Qual 23(4): 338-44, Oct-Dec 2008.

Mark DG, Ku BS, Carr BG, Everett WW, Okusanya O, Horan A, Gracias VH, Dean AJ: Directed bedside transthoracic echocardiography: preferred cardiac window for left ventricular ejection fraction estimation in critically ill patients. Am J Emerg Med 25(8): 894-900, Oct 2007.

Carr BG, Dean AJ, Everett WW, Ku BS, Mark DG, Okusanya O, Horan AD, Gracias VH: Intensivist bedside ultrasound (INBU) for volume assessment in the intensive care unit: a pilot study. J Trauma 63(3): 495-502, Sep 2007.

Woodfield GW, Horan, AD, Chen Y, Weigel RJ: TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling. Cancer Res 67(18): 8439-43, Sep 15 2007.

Gracias VH, Horan AD, Kim PK, Puri NK, Gupta R, Gallagher JJ, Sicoutris CP, Grasso M, Hanson CW, Schwab CW: Digital output volumetric pulmonary artery catheters eliminate interoperator interpretation variability and improve consistency of treatment decisions. J Am Coll Surg 204(2): 209-215, Feb 2007.

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Last updated: 11/30/2018
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