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Maurizio Pacifici, PhD

Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
The Children's Hospital of Philadelphia
Translational Research Program in Pediatric Orthopaedics
Division of Orthopaedic Surgery
Department of Surgery
3615 Civic Center Boulevard
Abramson Research Center 902D
Philadelphia, PA 19104
Office: 267-425-2073
Fax: 267-426-2215
Liceo Scientifico, 1969.
University of Rome School of Medicine, Institute of Histology & Embryology, 1974.
Post-Graduate Training
Fellowship, University of Pennsylvania School of Medicine, Department of Anatomy, 1975-1976.
Postdoc Research, University of Pennsylvania School of Medicine, Department of Anatomy, 1976-1977.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Shimono, K., Tung, W.-E., Macolino, C., Chi, A.H.-T., Didizian, J.J., Mundy, C., Chandraratna, R.A., Mishina, Y., Enomoto-Iwamoto, M., Pacifici, M., Iwamoto, M.: Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor gamma agonists. Nature Medicine 2011 Notes: in press.

Yusahara R., Yuasa, T., Williams, J., Byers, S., Shah, S., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M.: Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover. Journal of Biological Chemistry 285: 317-327, 2010.

Mundy, C., Yasuda, T., Kinumatsu, T., Yamaguchi, Y., Iwamoto, M., Enomoto-Iwamoto, M., Koyama, E., Pacifici, M.: Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryos limbs and spine. Developmental Biology 2010.

Koyama, E., Yasuda, T., Wellik, D.M., Pacifici, M.: Hox11 paralogous genes are required for formation of wrist and ankle joints and articular surface organization. Annals of the New York Academy of Sciences 1192: 307-316, 2010.

Sugito, H., Shibukawa, Y., Kinumatsu, T., Yasuda, T., Nagayama, M., Yamada, S., Minugh-Purvis, N., Pacifici, M., Koyama, E.: Ihh signaling regulates mandibular symphysis development and growth. Journal of Dental Research 2010 Notes: In press.

Anderson, D.G., Markova, D., Adams, S.L., Pacifici, M., An, H.S., Zhang, Y.: Fibronectin splicing variants in human intervertebral disc and association with disc degeneration. Spine 35: 1581-1588, 2010.

Shimono, K., Morrison, T.N., Tung, W.-E., Chandraratna, R.A., Williams, J.A., Iwamoto, M., Pacifici, M.: Inhibition of ectopic bone formation by a selective retinoic acid receptor alpha agonist: a new therapy for heterotopic ossification? Journal of Orthopaedic Research 28: 271-277, 2010.

Kondo N., Yuasa, T., Shimono, K., Tung, W., Okabe, T., Yasuhara, R., Pacifici, M., Zhang, Y., Iwamoto, M., Enomoto-Iwamoto, M.: Imbalance of Wnt/beta-catenin signaling causes deformity of intervetebral disc organization. Spine 2010.

Koyama, E., Yasuda, T., Minugh-Purvs, N., Kinumatsu, T., Yallowitz, A.R., Wellik, D.M., Pacifici, M.: Hox 11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements. Development 137: 3795-3800, 2010.

Williams, J.A., Kane, M., Okabe, T., Enomoto-Iwamoto, M., Napoli, J.L., Pacifici, M., Iwamoto, M.: Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover. Journal of Biological Chemistry 285: 36674-36681, 2010.

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Last updated: 10/21/2011
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