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Kristy L. Weber, MD

Abramson Family Professor in Sarcoma Care Excellence
Department: Orthopaedic Surgery

Contact information
Hospital of the University of Pennsylvania, 3400 Spruce Street, 2 Silverstein
Philadelphia, PA 19104
Office: 215-349-8200
Fax: 215-349-5890
B.S. (Animal Science (Summa cum Laude))
University of Missouri - Columbia, 1987.
M.D. (Medicine)
Johns Hopkins School of Medicine, 1991.
Post-Graduate Training
Intern and Resident, Orthopaedic Surgery, University of Iowa Hospitals and Clinics Iowa City, Iowa, 1991-1996.
Research Fellow, Orthopaedic Oncology, Mayo Clinic Rochester, Minnesota, 1996-1997.
Clinical Fellow, Orthopaedic Oncology, Mayo Clinic Rochester, Minnesota, 1997-1998.
American Board of Orthopaedic Surgery, 2000.
American Board of Orthopaedic Surgery, Recertification valid through 12/31/20, 2008.
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Description of Clinical Expertise

Fellowship trained orthopaedic oncologist specializing in complex limb salvage surgery around the hip/knee/shoulder/pelvis using metal prostheses, structural allografts/vascularized fibular grafts, and biologic reconstructions in skeletally immature patients.

Sees patients of all ages with benign/malignant soft tissue or bone tumors.

Sees patients with metastatic bone disease from other original sites (ie breast, prostate, lung, kidney, thyroid, etc).

Directs a multidisciplinary team including surgeons, radiation oncologists, and medical/pediatric oncologist to take care of patients with musculoskeletal tumors.

Diagnoses bone and soft tissue tumors using image-guided needle biopsies.

Description of Research Expertise

Specializes in murine models of bone metastasis from breast and kidney.

Additional expertise in osteosarcoma murine models studying local tumor growth in bone and metastasis to the lungs.

Focused on identifying unique molecular targets in both breast and renal cancer.

Utilizes novel drug therapies to treat bone destruction and systemic metastasis in breast and renal cancer murine models.

Selected Publications

Weber K: Part 4 of a series of interviews with Janet S. Wright, MD, Senior VP of Science and Quality at the American College of Cardiology on Quality Initiatives. AAOS Now Podcast March 2014.

Davalos-Bichara M, Lin FR, Carey JP, Walston JD, Fairman JE, Schubert MC, Barron JS, Hughes J, Millar JL, Spar A, Weber KL, Ying HS, Zackowski KM, Zee D, Agrawal Y: Development and Validation of a Falls-Grading Scale. Journal of Geriatric Physical Therapy 36(2): 63-67, Apr-Jun 2013.

Weber, KL: Musculoskeletal Oncology and Systemic Disease. AAOS Comprehensive Orthopaedic Review. Boyer M (eds.). American Academy of Orthopaedic Surgeons, Rosemont IL, In Press 2013 Notes: In Press.

Lau WM, Doucet M, Stadel R, Huang D, Weber KL, Kominsky SL: ENPP1: A Potential Facilitator of Breast Cancer Bone Metastasis. PLoS One In Press 2013.

Del Grande F, Subhawong T, Weber KL, Fayad L: Detection of Soft Tissue Sarcoma Recurrence: Added Value of Functional MR Imaging Techniques at 3T. Radiology In Press 2013.

Mugera C, Belzberg A, Suh KJ, Weber KL, Carrino J, Huisman T, Chabbra A: Sclerotic Lesions of the Spine - MRI Assessment. Journal of Magnetic Resonance Imaging In Press 2013.

Lau WM, Doucet M, Huang D, Weber KL, Kominsky SL: CITED2 Modulates Estrogen Receptor Transcriptional Activity in Breast Cancer Cells. Biochemical and Biophysical Research Communications In Press 2013.

Weber KL and Kominsky : Concepts and Surgical Treatment of Metastatic Bone Disease. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, (8th ed). Guise et al (eds.). ASBMR, 2013.

Miclau T, Moshed S, Weber KL (Section 1 Editors): Principles of Orthopaedics (Section 1). AAOS Orthopaedic Knowledge Update 11. Cannada L (eds.). American Academy of Orthopaedic Surgeons, Rosemont IL, In Press 2013.

Turkelson C and Weber KL: The Scientific Foundations of Healthcare Guidelines. In Orthopaedic Basic Science: Foundations of Clinical Practice, ed 4. O’Keefe RJ, Jacobs JJ, Chu CR, and Einhorn TA, eds (eds.). Rosemont, IL, American Academy of Orthopaedic Surgeons, 2013.

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Last updated: 03/20/2023
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