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Frederick S. Kaplan, M.D.

Isaac and Rose Nassau Professor of Orthopaedic Molecular Medicine in Orthopaedic Surgery
Attending Physician; Hospital of the University of Pennsylvania, Children's Hospital of Philadelphia, and Veteran's Administration Hospital of Philadelphia
Chief; Division of Metabolic Bone Diseases, University of Pennsylvania School of Medicine. Director; Metabolic Bone Disease Clinic, Hospital of the University of Pennsylvania
Academic Coordinator; Department of Orthopaedic Surgery, Penn
Director; Molecular Orthopaedics, Penn
Member , Institute on Aging, Penn
Director;, Center for Orthopaedic Research in FOP & Related Disorders
Director, Center for Research on Fibrodysplasia Ossificans Progressiva and Related Disorders, Penn
Institute for Human Gene Therapy, Penn
Center for Developmental Biology, Penn
Scientific Director, FOP Developmental Grants Program
Ad Hoc Consultant, , National Research Council. Intelligence Analysis for National Security. Office of the Director of National Intelligence
Chairman, Committee on Appointments & Promotions, Department of Orthopaedic Surgery, Penn
Executive Committee, Department of Orthopaedic Surgery, Penn
Department: Orthopaedic Surgery

Contact information
Penn Medicine University City
Department of Orthopaedic Surgery
3737 Market Street, 6th floor
Philadelphia, PA 19104
Office: 215-294-9145
Fax: 215-222-8854
Lab: 215-898-2330
Johns Hopkins University, 1972.
Johns Hopkins University, 1976.
Post-Graduate Training
Intern; Surgery, Hospital of the University of Pennsylvania, 1976-1977.
Resident; Orthopaedic Surgery, Hospital of the University of Pennsylvania and Children's Hospital of Philadelphia, 1977-1980.
Chief Resident; Orthopaedic Surgery, Hospital of the University of Pennsylvania and Children's Hospital of Philadelphia, 1980-1981.
Short Course In Medical and Experimental Mammalian Genetics, The Jackson Laboratory. Bar Harbor, Maine, 1988-1988.
John A. Hartford Research Fellowship in Molecular Biology. Laboratory of Michael A. Zasloff, M.D., Ph.D. , Division of Human Genetics and Molecular Biology. Children's Hospital of Philadelphia, 1989-1991.
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Description of Other Expertise

Frederick S. Kaplan, M.D. is The Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine and Chief of the Division of Molecular Orthopaedic Medicine at the University of Pennsylvania School of Medicine. He is an alumnus of The Johns Hopkins University School of Medicine (1976), and was Chief Resident in Orthopaedic Surgery at The Hospital of The University of Pennsylvania and The Children’s Hospital of Philadelphia from 1980 to 1981.

Kaplan was a Hartford Foundation Research Fellow in human genetics and molecular biology from 1989 to 1991 in the laboratory of his mentor and friend Dr. Michael Zasloff. This experience led to his exploration of the mechanisms for heterotopic bone formation and skeletal metamorphosis in several disabling childhood diseases.

In 1989, Kaplan, an orthopaedic surgeon, met a child with fibrodysplasia ossificans progressiva (FOP), a rare and disabling disorder in which the body forms a second skeleton of heterotopic bone. Motivated to know and do more, Kaplan began a pioneering second career on the molecular genetics of heterotopic ossification, work that led to the discovery of the FOP gene, to the description of the molecular pathophysiology of skeletal metamorphosis in humans, to the discovery of progressive osseous heteroplasia (another disorder of heterotopic ossification) and its causative gene and pathophysiology.

Along with his colleague Dr. Eileen Shore, Kaplan co-directs the only center in the world devoted entirely to this work, has organized the medical and scientific communities worldwide on these two rare conditions, and is recognized as the world’s leading expert on genetic disorders of heterotopic ossification and skeletal metamorphosis. In 1997, Kaplan was awarded the first endowed chair in the nation for orthopaedic molecular medicine.

The late Victor McKusick, the father of clinical genetics, described Kaplan as “one of the really outstanding orthopaedic researchers of his generation. His work with FOP and POH has been extraordinary and extends all the way from the patients to the bench and back again. The devotion of the families and the patients to him is testimony to the kind of human being he is.” Cited in 2006, as one of the15 people who make America great, Newsweek noted “the disease was so rare, nobody wanted to deal with it until he came along.”

Selected Publications

Pignolo RJ, Shore EM, Kaplan FS.: Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Emerging Concepts in Pediatric Bone Disease. Pediatric Endocrinology Reviews. 10(S-2):: 437-448, 2013.

Zhang W, Zhang K, Song L, Pang J, Ma H, Shore EM, Kaplan FS, Wang P.: The phenotype and genotype of fibrodysplasia ossificans progressiva in China: A report of 72 cases Bone 57: 386-391, 2013.

Regard JB, Malhotra D, Gvozdanovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y.: Activation of hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19: 1505-1512, 2013.

Cairns DM, Pignolo RJ, Uchimura T, Brennan TA, Lindborg CM, Xu M. *Kaplan FS, Shore EM, *Zeng L.(*co-senior authors).: Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. , 2013. J Clin Invest 123: 3624-3633, 2013.

Kaplan FS.: The skeleton in the closet. Gene 528:: 7-11, 2013.

Mohler ER, Kaplan FS, Pignolo RJ.: Boning-up on aortic valve calcification. J Am Coll Cardiol 60: 1954-1955, 2012.

Zimmer J, Doelken SC, Horn D, Groppe JC, Shore EM, Kaplan FS, Seemann P.: Functional analysis of alleged NOGGIN Mutation G92E disproves its pathogenic relevance. PLoS One 7 ((4): e35062: ): 1-7, 2012.

Kitterman JA, Strober JB, Kan L, Rocke DM, Cali A, Peeper J, Snow J, Delai PLR, Morhart R, Pignolo RJ, Shore EM, Kaplan FS. : Neurological symptoms in individuals with fibrodysplasia ossificans progressiva. J Neurol 2012.

La Sala LF, Pozzi LM, McAloose D, Kaplan FS, Shore EM, Kompanje EJ, Sidor IF, Musmeci L, Uhart MM. : Severe soft tissue ossification in a southern right whale Eubalanea australis Dis Aquat Organ 102: 149-156, 2012.

Kaplan FS, Chakkalakal SA, Shore EM.: Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis. Dis Model Mech 5: 756-762, 2012.

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Last updated: 11/06/2017
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