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James Nathan Palmer, MD

David W. Kennedy, MD Professor
Fellowship Director, Rhinology and Skull Base Surgery, University of Pennsylvania
Director, Division of Rhinology, Department of Otorhinolaryngology – Head and Neck Surgery, University of Pennsylvania
Physician, Penn Center for Cranial Base Surgery, University of Pennsylvania
Co-Director, Penn Center for Cranial Base Surgery, University of Pennsylvania
Department: Otorhinolaryngology: Head and Neck Surgery

Contact information
Hospital of the University of Pennsylvania
Department of Otorhinolaryngology - Head and Neck Surgery
3400 Spruce Street, 5 Silverstein
Philadelphia, PA 19104-4283
Office: 2156627746
Fax: 2156140071
B.A. (Chemistry)
University of Chicago, 1990.
The Ohio State University, 1995.
Post-Graduate Training
Fellow, The Stanley J. Sarnoff Endowment for Research in Cardiovascular Science, 1992-1993.
Intern in General Surgery , Northwestern Memorial Hospital, 1995-1996.
Resident in Otolaryngology-HNS, Northwestern Memorial Hospital, 1996-2000.
Fellow in Rhinology and Sinus Surgery, Georgia Nasal and Sinus Institute, 2000-2001.
Daiichi Clinical Scholar, AAO-HNS Foundation, 2001-2002.
American Board of Otolaryngology, 2001.
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> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Minimally Invasive Approaches to Sinus and Skull Base Tumors
Surgical Instrument Design
Topical Medications for Sinusitis
Novel Therapeutics for Recalcitrant Chronic Rhinosinusitis
Bacterial Biofilms and Chronic Rhinosinusitis
Cilia Function and Chronic Rhinosinusitis

Description of Clinical Expertise

Revision Endoscopic Sinus Surgery
Frontal Sinus Surgery
Minimally Invasive Sinus Cancer Surgery
Endoscopic Skull Base Surgery
Endoscopic CSF Leak Repair
Surgical Management of Epistaxis
Management of Recalicitrant Chronic Rhinosinusitis

Selected Publications

Suh JD, Cohen NA, Palmer JN: Biofilms in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 18(1): 27-31, Feb 2010.

Bleier BS, Cohen NA, Chiu AG, O'Malley BW Jr, Doghramji L, Palmer JN: Endonasal laser tissue welding: first human experience. Am J Rhinol Allergy 24(3): 244-6, May 2010.

Suh JD, Ramakrishnan V, Palmer JN: Biofilms. Otolaryngol Clin North Am 43(3): 521-30, Jun 2010.

Hekiert AM, Cohen MB, Montone KT, Palmer JN, Govindaraj S: Ecthyma gangrenosum mimicking acute invasive fungal sinusitis in an immunocompromised patient. Ear Nose Throat J 89(6): 262-7, Jun 2010.

Ramakrishnan VR, Palmer JN: Prevention and management of orbital hematoma. Otolaryngol Clin North Am 43(4): 789-800, Aug 2010.

Woodworth BA, Zhang S, Tamashiro E, Bhargave G, Palmer JN, Cohen NA: Zinc increases ciliary beat frequency in a calcium-dependent manner. Am J Rhinol Allergy 24(1): 6-10, Jan-Feb 2010.

Welch KC, Thaler ER, Doghramji LL, Palmer JN, Chiu AG: The effects of serum and urinary cortisol levels of topical intranasal irrigations with budesonide added to saline in patients with recurrent polyposis after endoscopic sinus surgery. Am J Rhinol Allergy 24(1): 26-8, Jan-Feb 2010.

Purkey MT, Woodworth BA, Hahn S, Palmer JN, Chiu AG: Endoscopic Repair of Supraorbital Ethmoid Cerebrospinal Fluid Leaks. ORL J Otorhinolaryngol Relat Spec 71(2): 93-98, Jan 2009.

Bleier BS, Paulson DP, O'Malley BW Jr, Li D, Palmer JN, Chiu AG, Cohen NA: Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent. Am J Rhinol Allergy 23(1): 76-9, Jan-Feb 2009.

Tamashiro E, Xiong G, Anselmo-Lima WT, Kreindler JL, Palmer JN, Cohen NA: Cigarette smoke exposure impairs respiratory epithelial ciliogenesis. Am J Rhinol Allergy 23(2): 117-22, Mar-Apr 2009.

Barañano CF, Curé J, Palmer JN, Woodworth BA: Sternberg's canal: fact or fiction? Am J Rhinol Allergy 23(2): 167-71, Mar-Apr 2009.

Cohen M, Kofonow J, Nayak JV, Palmer JN, Chiu AG, Leid JG, Cohen NA: Biofilms in chronic rhinosinusitis: a review. Am J Rhinol Allergy 23(3): 255-60, May-Jun 2009.

Bleier BS, Kennedy DW, Palmer JN, Chiu AG, Bloom JD, O'Malley BW, Jr: Current management of juvenile nasopharyngeal angiofibroma: a tertiary center experience 1999-2007. Am J Rhinol Allergy 23(3): 328-30, May-Jun 2009.

Hahn S, Palmer JN, Purkey MT, Kennedy DW, Chiu AG: Indications for external frontal sinus procedures for inflammatory sinus disease. Am J Rhinol Allergy 23(3): 342-7, May-Jun 2009.

Banks CA, Palmer JN, Chiu AG, O'Malley BW Jr, Woodworth BA, Kennedy DW: Endoscopic closure of CSF rhinorrhea: 193 cases over 21 years. Otolaryngol Head Neck Surg 140(6): 826-33, Jun 2009.

Tamashiro E, Antunes MB, Palmer JN, Cohen NA, Anselmo-Lima WT: Implications of bacterial biofilms in chronic rhinosinusitis. Braz J Infect Dis 13(3): 232-5, Jun 2009.

Welch KC, Cohen MB, Doghramji LL, Cohen NA, Chandra RK, Palmer JN, Chiu AG: Clinical correlation between irrigation bottle contamination and clinical outcomes in post-functional endoscopic sinus surgery patients. Am J Rhinol Allergy 23(4): 401-4, Jul-Aug 2009.

Hekiert AM, Kofonow JM, Doghramji L, Kennedy DW, Chiu AG, Palmer JN, Leid JG, Cohen NA: Biofilms correlate with TH1 inflammation in the sinonasal tissue of patients with chronic rhinosinusitis. Otolaryngol Head Neck Surg 141(4): 448-53, Oct 2009.

Bleier BS, Palmer JN: Cranial-base repair using endoscopic laser welding. Otolaryngol Clin North Am 42(5): 901-6, Oct 2009.

Tamashiro E, Cohen NA, Palmer JN, Lima WT: Effects of cigarette smoking on the respiratory epithelium and its role in the pathogenesis of chronic rhinosinusitis. Braz J Otorhinolaryngol 75(6): 903-7, Dec 2009.

Woodworth BA, Palmer JN: Spontaneous cerebrospinal fluid leaks. Curr Opin Otolaryngol Head Neck Surg 17(1): 59-65, Feb 2009.

Bleier BS, Palmer JN, Gratton MA, Cohen NA: In vivo laser tissue welding in the rabbit maxillary sinus. Am J Rhinol 22(6): 625-8, Nov-Dec 2008.

Woodworth BA, Chiu AG, Cohen NA, Kennedy DW, O'Malley BW, Palmer JN: Real-time computed tomography image update for endoscopic skull base surgery. J Laryngol Otol 122(4): 361-5, Apr 2008.

Chiu AG, Palmer JN, Woodworth BA, Doghramji L, Cohen MB, Prince A, Cohen NA: Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient. Am J Rhinol 22(1): 34-7, Jan-Feb 2008.

Jackman AH, Palmer JN, Chiu AG, Kennedy DW: Use of intraoperative CT scanning in endoscopic sinus surgery: a preliminary report. Am J Rhinol 22(2): 170-4, Mar-Apr 2008.

Welch KC, Palmer JN: Intraoperative emergencies during endoscopic sinus surgery: CSF leak and orbital hematoma. Otolaryngol Clin North Am 41(3): 581-96, Jun 2008.

Whitmore RG, Bonhomme G, Balcer LJ, Palmer JN: Tension pneumocephalus after endoscopic sinus surgery: case report of repair and management in absence of obvious skull base defect. Ear Nose Throat J 87(2): 96-9, Feb 2008.

Chennupati SK, Woodworth BA, Palmer JN, Cohen NA, Kennedy DW, Chiu AG: Intraoperative IGS/CT updates for complex endoscopic frontal sinus surgery. ORL J Otorhinolaryngol Relat Spec 70(4): 268-70, 2008.

Woodworth BA, Prince A, Chiu AG, Cohen NA, Schlosser RJ, Bolger WE, Kennedy DW, Palmer JN: Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension. Otolaryngol Head Neck Surg 138(6): 715-20, Jun 2008.

Prince AA, Steiger JD, Khalid AN, Dogrhamji L, Reger C, Eau Claire S, Chiu AG, Kennedy DW, Palmer JN, Cohen NA: Prevalence of biofilm-forming bacteria in chronic rhinosinusitis. Am J Rhinol 22(3): 239-45, May-Jun 2008.

Woodworth BA, Harvey RJ, Neal JG, Palmer JN, Schlosser RJ: Endoscopic management of frontal sinus mucoeceles with anterior table erosion. Rhinology 46(3): 231-7, Sep 2008.

Khalid AN, Woodworth BA, Prince A, Quraishi SA, Antunes MB, Long FH, Bolger WE, Chiu AG, Palmer JN, Cohen NA: Physiologic alterations in the murine model after nasal fungal antigenic exposure. Otolaryngol Head Neck Surg 139(5): 695-701, Nov 2008.

Bleier BS, Gratton MA, Leibowitz JM, Palmer JN, Newman JG, Cohen NA: Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model. Otolaryngol Head Neck Surg 139(5): 713-7, Nov 2008.

Woodworth BA, Bhargave GA, Palmer JN, Chiu AG, Cohen NA, Lanza DC, Bolger WE, Kennedy DW: Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: a 15-year experience. Am J Rhinol 21(5): 591-600, Sep-Oct 2007.

Chiu AG, Antunes MB, Palmer JN, Cohen NA: Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms. J Antimicrobial Chemothe 59(6): 1130-4, Jun 2007.

Chen B, Antunes MB, Claire SE, Palmer JN, Chiu AG, Kennedy DW, Cohen NA: Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction. Am J Rhinol 21(3): 346-53, May-Jun 2007.

Tamhankar MA, Volpe NJ, Loevner LA, Palmer JN, Feldman M: Primary sinonasal undifferentiated carcinoma presenting with bilateral retrobulbar optic neuropathy. J Neuroophthalmol 27(3): 189-92, Sep 2007.

Bleier BS, Palmer JN, Sparano AM, Cohen NA: Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility. Otolaryngol Head Neck Surg 137(5): 810-4, Nov 2007.

Woodworth BA, Antunes MB, Bhargave G, Palmer JN, Cohen NA: Murine tracheal and nasal septal epithelium for air-liquid interface cultures: a comparative study. Am J Rhinol 21(5): 533-7, Sep-Oct 2007.

Schipor I, Palmer JN, Cohen AS, Cohen NA: Quantification of ciliary beat frequency in sinonasal epithelial cells using differential interference contrast microscopy and high-speed digital video imaging. Am J Rhinol 20(1): 124-7, Jan-Feb 2006.

Hockstein NG, Bales CB, Palmer JN: Transseptal suture to secure middle meatal spacers. Ear Nose Throat J 85(1): 47-8, Jan 2006.

Chiu AG, Jackman AH, Antunes MB, Feldman MD, Palmer JN: Radiographic and histologic analysis of the bone underlying inverted papillomas. Laryngoscope 116(9): 1617-20, Sep 2006.

Steiger JD, Chiu AG, Francis DO, Palmer JN: Endoscopic-assisted reduction of anterior table frontal sinus fractures. Laryngoscope 116(11): 1978-81, Nov 2006.

Palmer, JN, Hockstein, NG: Medical and Surgical Treatment of Recurrent Chronic Sinusitis. Endoscopic Sinus Surgery. DeSouza, A (eds.). McGraw Hill Inter Americana, 2008.

Palmer JN: Bacterial biofilms in chronic rhinosinusitis. Twenty years of endoscopic sinus surgery: its evolution and future directions. Annals of Otology, Rhinology, & Laryngology. Kennedy DW (eds.). 115 (196): 35-39, 2006.

Chandra RK, Palmer JN: Epidermoids of the Paranasal Sinuses and Beyond: Endoscopic Management. Am J Rhinol 20(4): 441-4, Jul-Aug 2006.

Lee JT, Kennedy DW, Palmer JN, Feldman M, Chiu AG: The Incidence of Concurrent Osteitis in Patients with CRS: A Clinicopatholigic Study. Am J Rhinol 20(3): 278-82, May-Jun 2006.

Chen B, Shaari J, Claire SE, Palmer JN, Chiu AG, Kennedy DW, Cohen NA: Altered Sinonasal Ciliary Dynamics in Chronic Rhinosinusitis. Am J Rhinol 20(3): 325-329, May-Jun 2006.

Shaari J, Palmer JN, Judy K, Chen B, Cohen NA: Regional Analysis of Sinonasal Ciliary Beat Frequency. Am J Rhinol 20(2): 150-4, Mar-Apr 2006.

Cohen NA, Widelitz JS, Chiu AG, Palmer JN, Kennedy DW: Familial aggregation of sinonasal polyps correlates with severity of disease. Otolaryngol Head Neck Surg 134(4): 601-4, Apr 2006.

Perloff JR, Palmer JN: Evidence of bacterial biofilms in a rabbit model of sinusitis. Am J Rhinol 19(1): 1-6, Feb 2005.

Wolf JS, Chiu AG, Palmer JN, O'Malley BW Jr, Schofield K, Taylor RJ: Informed consent in endoscopic sinus surgery: the patient perspective. Laryngoscope 115(3): 492-4, Mar 2005.

Chiu AG, Palmer JN, Cohen N: Use of image-guided computed tomography-magnetic resonance fusion for complex endoscopic sinus and skull base surgery. Laryngoscope 115(4): 753-5, Apr 2005.

Taylor RJ, Chiu AG, Palmer JN, Schofield K, O'Malley BW Jr, Wolf JS: Informed consent in sinus surgery: link between demographics and patient desires. Laryngoscope 115(5): 826-31, May 2005.

Hockstein NG, Cohen NA, Palmer JN: Proteolysis of beta-trace Protein? Otolaryngol Head Neck Surg 133(2): 310; author reply 310-1, Aug 2005 Notes: Letter to the editor.

Woodworth BA, Tamashiro E, Bhargave G, Cohen NA, Palmer JN: An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers. Am J Rhinol 22(3): 235-8, May-Jun 2008.

Cohen NA, Chiu AG, Kennedy DW, Chen B, Palmer JN: Altered Sinonasal Ciliary Dynamics in Chronic Rhinosinusitis. American Rhinologic Society, Los Angeles, CA Sep 2005.

Woodworth BA, Schlosser RJ, Palmer JN: Endoscopic repair of frontal sinus cerebrospinal fluid leaks. J Larygol Otol 119(9): 709-13, Sep 2005.

Chiu AG, Schipor I, Cohen NA, Kennedy DW, Palmer JN: Surgical decisions in the management of frontal sinus osteomas. Am J Rhinol 19(2): 191-7, Mar-Apr 2005.

Cryer J, Schipor I, Perloff JR, Palmer JN: Evidence of bacterial biofilms in human chronic sinusitis. J Otorhinolaryngol Relat Spec 66(3): 155-8, Mar 2004.

Chandra RK, Kennedy DW, Palmer JN: Endoscopic management of failed frontal sinus obliteration. Am J Rhinol 18(5): 279-84, Sept-Oct 2004.

Perloff JR, Palmer JN: Evidence of bacterial biofilms on frontal recess stents in patients with chronic rhinosinusitis. Am J Rhinol 18(6): 377-80, Nov-Dec 2004.

Meetze K, Palmer JN, Schlosser RJ: Frontal sinus complications after frontal craniotomy. Laryngoscope 114(5): 945-8, May 2004.

Palmer JN, Kennedy DW: Medical management in functional endoscopic sinus surgery failures. Curr Opin Otolaryngol Head Neck Surg 11(1): 6-12, Feb 2003.

Palmer JN, Conley DB, Dong RG, Ditto AM, Yarnold P R, Kern R C: Efficacy of endoscopic sinus surgery in the management of patients with asthma and chronic sinusitis. Am J Rhinology 15(1): 49-53, Jan-Feb 2001.

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Last updated: 08/27/2021
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