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Rabie M Shanti, D.M.D., M.D.

Assistant Professor of Otorhinolaryngology: Head and Neck Surgery
Attending Staff, Pennsylvania Hospital, Philadelphia, PA
Attending Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Staff, Penn Presbyterian Medical Center, Philadelphia, PA
Member, Center for Head and Neck Cancer, Abramson Cancer Center, Philadelphia, PA
University Associate Staff, Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Associate Director, Head & Neck Cancer Service Line, , Abramson Cancer Center/Penn Medicine
Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania
Vice Chair for Inclusion, Diversity and Equity, Department of Oral and Maxillofacial Surgery, University of Pennsylvania
Department: Otorhinolaryngology: Head and Neck Surgery

Contact information
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
B.S. (Biological Sciences, Summa Cum Laude)
Florida Atlantic University, 2002.
D.M.D. (Dental Medicine, Magna Cum Laude)
Harvard University School of Dental Medicine, 2008.
M.D. (Medicine)
New Jersey Medical School/Rutgers University, 2011.
Post-Graduate Training
Howard Hughes Medical Institute Research Scholar, National Institute of Health, Bethesda, MD, 2004-2006.
Residency in Oral and Maxillofacial Surgery , The University Hospital, Rutgers University, Newark, NJ, 2008-2014.
Internship in General Surgery, The University Hospital, University of Medicine and Dentistry of New Jersey, 2011-2012.
Fellowship in Oral, Head and Neck Oncologic Surgery, Microvascular Reconstructive Surgery, Louisiana State University, Shreveport, LA, 2014-2016.
American Board of Oral and Maxillofacial Surgery , 2018.
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Description of Clinical Expertise

Dr. Rabie Shanti holds a dual appointment in the Department of Oral and Maxillofacial Surgery at Penn Dental Medicine, and the Department of Otorhinolaryngology/Head and Neck Surgery at Penn Medicine. Dr. Shanti sees patients at Pennsylvania Hospital and the Hospital of the University of Pennsylvania where he focuses on the evaluation and surgical treatment of benign and malignant tumors of the head and neck, such as, benign tumors of the jaws (e.g., ameloblastoma, myxoma), malignant tumors of the jaws (e.g., osteosarcoma, chondrosarcoma), oral (mouth) cancer, and oropharyngeal (throat) cancer. Dr. Shanti frequently evaluates and manages advanced inflammatory conditions of the jaws, such as, osteoradionecrosis, and medication related osteonecrosis of the jaw. Dr. Shanti’s clinical practice is also devoted to microvascular reconstructive surgery of the head and neck following oncologic surgery, radiation injury, or trauma. As an active head and neck surgeon in the Center for Head and Neck Cancer at the Abramson Cancer Center, Dr. Shanti works side by side with his colleagues from otorhinolaryngology/head and neck surgery, radiation oncology, medical oncology, oral medicine, maxillofacial prosthodontics, pathology, speech-language pathology, nutrition, nursing, social work, and appropriate surgical subspecialties to provide his patients with patient-centered care aimed at optimizing disease control while providing the highest level of aesthetic/functional outcomes.

Description of Research Expertise

An extension of Dr. Shanti’s clinical interest in functional rehabilitation surgery through the utilization of reconstructive microsurgical techniques has been regenerative medicine. Dr. Shanti is currently investigating the potential of mesenchymal stem cells in tongue tissue engineering, as well as, the engineering of other orofacial tissues. This work is in collaboration with investigators from Penn Dental Medicine and Penn Medicine. Dr. Shanti also has a special interest in rare pathology of the head and neck, in investigating the pathogenesis of benign tumors and cysts of the jaw (i.e., ameloblastoma, odontogenic keratocyst, ossifying fibroma), and rare malignant tumors of the oral cavity (i.e., carcinosarcoma, osteosarcoma). Dr. Shanti has also been involved in investigative studies looking at complex infections of the head and neck (e.g., deep neck infections, osteomyelitis of the jaws) and for this work he was the co-recipient of the Daniel M. Laskin Award for the "most outstanding article published in the Journal of Oral and Maxillofacial Surgery in 2006."


Project title: Stromal cell-derived IL-6 promotes epithelial tumor stem-like cell generation by inducing epithelial-mesenchymal transition in ameloblastoma
Sponsoring Program: Oral & Maxillofacial Surgery Foundation Research Support Grant

Project title: Mesenchymal stromal cell-derived IL-6 facilitate EMT process and acquisition of stem-like cell properties in ameloblastoma epithelial cells
Sponsoring Program: Schoenleber Pilot Grant, School of Dental Medicine, University of Pennsylvania

Selected Publications

Zhang Q, Nguyen P, Burrell JC, Zeng J, Shi S, Shanti RM, Kulischak G, Cullen DK, Le AD: Harnessing 3D collagen hydrogel-directed conversion of human GMSCs into SCP-like cells to generate functionalized nerve conduits. NPJ Regenerative Medicine(6), 59, Sep 2021.

Tasche K, Rajasekaran K, Cannady SB, Chalian AA, Newman J, Shanti R, Brody R: The Incidence and Characteristics of Alternative Reconstructive Procedures in Planned Free Flap Surgery. American Head & Neck Society 10th International Conference on Head and Neck Cancer Jul 2021 Notes: Virtual Conference.

Tasche K, Rajasekaran K, Cannady SB, Chalian AA, Newman J, Shanti R, Brody R: The Impact of Departmental Expansion of Microvascular Reconstruction on Free Flap Rate and Volume. American Head & Neck Society 10th International Conference on Head and Neck Cancer Jul 2021 Notes: Virtual Conference.

Mohiuddin JJ, Shanti RM, Alawi F, Chang BM, Marcel J, Taunk NK, Lukens JN: High-dose-rate brachytherapy for primary treatment of refractory proliferative verrucous leukoplakia of the hard palate. Cureus 13(6): e15696, Jun 2021.

Behtaj M, Alawi F, Shanti RM, Cannady S, Zhang PJ, Modi M, Lamzabi I: Report of a rare case of spindle cell ameloblastic carcinoma and the diagnostic utility of immunohistochemistry. Applied Immunohistochemistry & Molecular Morphology 29(5): 394-400, May-Jun 2021.

Triantafillou V, Layfield E, Prasad A, Deng J, Shanti RM, Newman JG, Rajasekaran K: Patient perceptions of head and neck ambulatory telemedicine visits: a qualitative study. Otolaryngology-Head and Neck Surgery 164(5): 923-931, May 2021.

Moon HS, Wang TT, Rajasekaran K, Brewster R, Shanti RM, Panchal N: Optimizing telemedicine encounters for oral and maxillofacial surgeons during the COVID-19 pandemic. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 131(2): 166-172, Feb 2021.

Chao TN, Frost AS, Brody RM, Byrnes YM, Cannady SB, Luu NN, Rajasekaran K, Shanti RM, Silberthau KR, Triantafillou V, Newman JG: Creation of an interactive virtual surgical rotation for undergraduate medical education during COVID-19 pandemic. Journal of Surgical Education 78(1): 346-350, Jan-Feb 2021.

Yalamanchi P, Thomas WW, Workman AD, Rajasekaran K, Chalian AA, Shanti RM, Newman JG, Cannady SB: Value of intensive care unit-based postoperative management for microvascular free flap reconstruction in head and neck surgery. Facial Plastic Surgery & Aesthetic Medicine 23(1): 49-53, Jan-Feb 2021.

Graillon N, Iocca O, Carey RM, Benjamin K, Cannady SB, Hartner L, Newman JG, Rajasekaran K, Brant JA, Shanti RM: What Has the National Cancer Database (NCDB) Taught Us About Oral Cavity Squamous Cell Carcinoma? International Journal of Oral & Maxillofacial Surgery 2021 Notes: in press.

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Last updated: 11/30/2021
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