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Rabie M Shanti, D.M.D., M.D.

Assistant Professor of Otorhinolaryngology: Head and Neck Surgery
Attending Staff, Pennsylvania Hospital, Philadelphia, PA
Attending Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Staff, Penn Presbyterian Medical Center, Philadelphia, PA
Member, Center for Head and Neck Cancer, Abramson Cancer Center, Philadelphia, PA
University Associate Staff, Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Department: Otorhinolaryngology: Head and Neck Surgery

Contact information
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
B.S. (Biological Sciences)
Florida Atlantic University, 2002.
D.M.D. (Dental Medicine)
Harvard University School of Dental Medicine, 2008.
M.D. (Medicine)
New Jersey Medical School, 2011.
Post-Graduate Training
Howard Hughes Medical Institute Research Scholar, National Institute of Health, Bethesda, MD, 2004-2006.
Residency in Oral and Maxillofacial Surgery , The University Hospital, Rutgers University, Newark, NJ, 2008-2014.
Internship in General Surgery, The University Hospital, University of Medicine and Dentistry of New Jersey, 2011-2012.
Fellowship in Oral, Head and Neck Oncologic Surgery, Microvascular Reconstructive Surgery, Louisiana State University, Shreveport, LA, 2014-2016.
American Board of Oral and Maxillofacial Surgery , 2018.
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Description of Clinical Expertise

Dr. Rabie Shanti holds a dual appointment in the Department of Oral and Maxillofacial Surgery at Penn Dental Medicine, and the Department of Otorhinolaryngology/Head and Neck Surgery at Penn Medicine. Dr. Shanti sees patients at Pennsylvania Hospital and the Hospital of the University of Pennsylvania where he focuses on the evaluation and surgical treatment of benign and malignant tumors of the head and neck, such as, benign tumors of the jaws (e.g., ameloblastoma, myxoma), malignant tumors of the jaws (e.g., osteosarcoma, chondrosarcoma), oral (mouth) cancer, and oropharyngeal (throat) cancer. Dr. Shanti frequently evaluates and manages advanced inflammatory conditions of the jaws, such as, osteoradionecrosis, and medication related osteonecrosis of the jaw. Dr. Shanti’s clinical practice is also devoted to microvascular reconstructive surgery of the head and neck following oncologic surgery, radiation injury, or trauma. As an active head and neck surgeon in the Center for Head and Neck Cancer at the Abramson Cancer Center, Dr. Shanti works side by side with his colleagues from otorhinolaryngology/head and neck surgery, radiation oncology, medical oncology, oral medicine, maxillofacial prosthodontics, pathology, speech-language pathology, nutrition, nursing, social work, and appropriate surgical subspecialties to provide his patients with patient-centered care aimed at optimizing disease control while providing the highest level of aesthetic/functional outcomes.

Description of Research Expertise

An extension of Dr. Shanti’s clinical interest in functional rehabilitation surgery through the utilization of reconstructive microsurgical techniques has been regenerative medicine. Dr. Shanti is currently investigating the potential of mesenchymal stem cells in tongue tissue engineering, as well as, the engineering of other orofacial tissues. This work is in collaboration with investigators from Penn Dental Medicine and Penn Medicine. Dr. Shanti also has a special interest in rare pathology of the head and neck, in investigating the pathogenesis of benign tumors and cysts of the jaw (i.e., ameloblastoma, odontogenic keratocyst, ossifying fibroma), and rare malignant tumors of the oral cavity (i.e., carcinosarcoma, osteosarcoma). Dr. Shanti has also been involved in investigative studies looking at complex infections of the head and neck (e.g., deep neck infections, osteomyelitis of the jaws) and for this work he was the co-recipient of the Daniel M. Laskin Award for the "most outstanding article published in the Journal of Oral and Maxillofacial Surgery in 2006."


Project title: Stromal cell-derived IL-6 promotes epithelial tumor stem-like cell generation by inducing epithelial-mesenchymal transition in ameloblastoma
Sponsoring Program: Oral & Maxillofacial Surgery Foundation Research Support Grant

Project title: Mesenchymal stromal cell-derived IL-6 facilitate EMT process and acquisition of stem-like cell properties in ameloblastoma epithelial cells
Sponsoring Program: Schoenleber Pilot Grant, School of Dental Medicine, University of Pennsylvania

Selected Publications

Pratyusha Yalamanchi, William W Thomas, MD, Alan Workman, Karthik Rajasekaran, MD, Rabie M Shanti, DMD, MD, Ara C Chalian, MD, Jason G Newman, MD, Steven B Cannady, MD: Value of intensive care unit–based management for microvascular free flap reconstruction in head and neck surgery. Annual Meeting of the American Head and Neck Society April 2018.

Shang W, Zhang Q, Huang Y, Shanti R, Alawi F, Le D, Jiang C: Cellular plasticity-targeted therapy in head and neck cancers. Journal of Dental Research February 2018.

Shanti RM,O'Malley BW Jr. : Surgical management of oral cancer. Dental Clinics of North America 62(2): 77-86, January 2018.

Mupparapu M,Shanti RM: Evaluation and staging of oral cancer. Dental Clinics of North America 62(1): 47-58, January 2018.

Shanti RM, Smart RJ, Meram A, Kim D. : Porcine urinary bladder extracellular matrix for the salvage of fibula free flap skin paddle: technical note and description of a case. Craniomaxillofacial Trauma & Reconstruction 10(4): 318-22, December 2017.

Thomas WW, Brant J, Chen J, Coblens O, Fischer JP, Newman JG, Chalian AA, Shanti RM, Cannady SB: Clinical factors associated with reoperation and prolonged length of stay in free tissue transfer to oncologic head and neck defects. JAMA Facial Plastic Surgery November 2017.

Jiang C, Zhang Q, Shanti RM, Shi S, Chang TH, Carrasco L, Alawi F, Le AD: Mesenchymal stromal cell-derived interleukin-6 promotes epithelial-mesenchymal transition and acquisition of epithelial stem-like cell properties in ameloblastoma epithelial cells. Stem Cells 35 (9): 2083-94, July 2017.

Tanaka TI, Shanti RM: Coordinated care of a pregnant patient with nasopharyngeal carcinoma. American Academy of Oral Medicine Annual Conference April 2017.

Gomez ED, Thakkar P, Rajasekaran K, Brody R, Shanti R, Newman JG, Cannady SB : Patient characteristics as predictors of postoperative complications in free flap reconstruction for head and neck cancer. American Head & Neck Society Annual Meeting April 2017.

Shanti RM, Kim DD, Ghali GE. : Melanoma. Oral and Maxillofacial Surgery: 3 Volume Set, 3rd Edition. Fonseca RJ (eds.). Saunders, 2: 690-706, March 2017.

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Last updated: 06/10/2018
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