My research program focuses on the role of innate immunity, inflammation and human genomics in subclinical atherosclerosis. I have a particular interest in human genomics, in vivo inflammation and accelerated atherosclerosis. Our trans-disciplinary approach involves genetic epidemiology, cardiovascular radiology and translational medicine, all of which I have advanced training within to understand the role of cellular phenotypes, lipoproteins and common genetic variation on vascular inflammation. Our research program has advanced understanding of the epidemiological association between psoriasis and cardiometabolic diseases, as well as the first to demonstrate in vivo vascular inflammation in severe psoriasis utilizing novel imaging techniques.
My clinical expertise is in Preventive Cardiology, Nuclear Cardiology and General Cardiology. I am the director of the Inflammatory Risk Program which specializes in the preventive cardiometabolic care of patients with psoriasis. Our multidisciplinary approach is the first of its kind and has >200 active patients. I also interpret exercise nuclear tests at HUP and Radnor, as well as serve on the consult service and Coronary Care Unit service at HUP.
I have experience in medical media and have been featured on ABC News, MSNBC News, several magazines including Men's Health, Fitness as well as newspapers both local and national. Most of the commentary focus on emerging studies on factors of risk for vascular and metabolic diseases, as well as epidemiology of cardiovascular diseases in general. I also speak at several patient-based and community-based lecture series, and write extensively for the lay population on heart disease risk.
Selected Publications
Bowman, E. R., Cameron, C. M., Richardson, B., Kulkarni, M., Gabriel, J., Cichon, M. J., Riedl, K. M., Mustafa, Y., Cartwright, M., Snyder, B., Raman, S. V., Zidar, D. A., Koletar, S. L., Playford, M. P., Mehta, N. N., Sieg, S. F., Freeman, M. L., Lederman, M. M., Cameron, M. J., Funderburg, N. T.: Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms. PLoS Pathog 16(10): e1008869, 2020.
Lateef, S. S., Al Najafi, M., Dey, A. K., Batool, M., Abdelrahman, K. M., Uceda, D. E., Reddy, A. S., Svirydava, M. D., Nanda, N., Ortiz, J. E., Prakash, N., Rodante, J. A., Keel, A., Zhou, W., Chen, M. Y., Playford, M. P., Teague, H. L., Tawakol, A. A., Gelfand, J. M., Powell-Wiley, T. M., Mehta, N. N.: Relationship between chronic stress-related neural activity, physiological dysregulation and coronary artery disease in psoriasis: Findings from a longitudinal observational cohort study. Atherosclerosis 310: 37-44, 2020.
Gordon, S. M., Amar, M. J., Jeiran, K., Stagliano, M., Staller, E., Playford, M. P., Mehta, N. N., Vaisar, T., Remaley, A. T.: Effect of niacin monotherapy on high density lipoprotein composition and function. Lipids Health Dis 19(1): 190, 2020.
Abdelrahman, K. M., Chen, M. Y., Dey, A. K., Virmani, R., Finn, A. V., Khamis, R. Y., Choi, A. D., Min, J. K., Williams, M. C., Buckler, A. J., Taylor, C. A., Rogers, C., Samady, H., Antoniades, C., Shaw, L. J., Budoff, M. J., Hoffmann, U., Blankstein, R., Narula, J., Mehta, N. N.: Coronary Computed Tomography Angiography From Clinical Uses to Emerging Technologies: JACC State-of-the-Art Review. J Am Coll Cardiol 76(10): 1226-1243, 2020.
Andrews, M. R., Ceasar, J., Tamura, K., Langerman, S. D., Mitchell, V. M., Collins, B. S., Baumer, Y., Gutierrez Huerta, C. A., Dey, A. K., Playford, M. P., Mehta, N. N., Powell-Wiley, T. M.: Neighborhood environment perceptions associate with depression levels and cardiovascular risk among middle-aged and older adults: Data from the Washington, DC cardiovascular health and needs assessment. Aging Ment Health Page: 1-12, 2020.
Bashant, K. R., Aponte, A. M., Randazzo, D., Rezvan Sangsari, P., Wood, A. J., Bibby, J. A., West, E. E., Vassallo, A., Manna, Z. G., Playford, M. P., Jordan, N., Hasni, S., Gucek, M., Kemper, C., Conway Morris, A., Morgan, N. Y., Toepfner, N., Guck, J., Mehta, N. N., Chilvers, E. R., Summers, C., Kaplan, M. J.: Proteomic, biomechanical and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus. Ann Rheum Dis 2020.
Bashant, K. R., Toepfner, N., Day, C. J., Mehta, N. N., Kaplan, M. J., Summers, C., Guck, J., Chilvers, E. R.: The mechanics of myeloid cells. Biol Cell 112(4): 103-112, 2020.
Baumer, Y., Dey, A. K., Gutierrez-Huerta, C. A., Khalil, N. O., Sekine, Y., Sanda, G. E., Zhuang, J., Saxena, A., Stempinski, E., Elnabawi, Y. A., Dagur, P. K., Ng, Q., Teague, H. L., Keel, A., Rodante, J. A., Boisvert, W. A., Tsoi, L. C., Gudjonsson, J. E., Bleck, C. K. E., Chen, M. Y., Bluemke, D. A., Gelfand, J. M., Schwartz, D. M., Kruth, H. S., Powell-Wiley, T. M., Playford, M. P., Mehta, N. N.: Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis. EBioMedicine 59: 102876, 2020.
Baumer, Y., Gutierrez-Huerta, C. A., Saxena, A., Dagur, P. K., Langerman, S. D., Tamura, K., Ceasar, J. N., Andrews, M. R., Mitchell, V., Collins, B. S., Yu, Q., Teague, H. L., Playford, M. P., Bleck, C. K. E., Mehta, N. N., McCoy, J. P., Powell-Wiley, T. M.: Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study. J Transl Med 18(1): 29, 2020.
Baumer, Y., Mehta, N. N., Dey, A. K., Powell-Wiley, T. M., Boisvert, W. A.: Cholesterol crystals and atherosclerosis. Eur Heart J 41(24): 2236-2239, 2020.
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Last updated: 10/28/2020
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