David S Frankel - Faculty Biosketch

David S Frankel, MD

Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania

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Department: Medicine

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46 Contact information
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Pavilion at the Hospital of the University of Pennsylvania
18 1 Convention Ave
37 2nd Floor, City Side
Philadelphia, PA 19104

2e Office: 215-662-6801
32 Fax: 215-615-4350
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Email:
david.frankel@pennmedicine.upenn.edu

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13 Education:
21 7 BA 1d (American History) c
63 University of Pennsylvania, College of Arts and Sciences, Philadelphia, PA, 2000.
21 7 MD c
59 University of Pennsylvania, School of Medicine, Philadelphia, PA, 2004.
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1f Post-Graduate Training
24 4c Intern in Internal Medicine, Massachusetts General Hospital, Boston, MA 1b , 2004-2005.
24 4e Resident in Internal Medicine, Massachusetts General Hospital, Boston, MA 1b , 2005-2007.
24 63 Fellow in Cardiovascular Disease, Hospital of the University of Pennsylvania, Philadelphia, PA 2 1b , 2007-2009.
24 67 Fellow in Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia, PA 2 1b , 2009-2011.
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17 Certifications
28 3c American Board of Internal Medicine, 2007.
28 42 American Board of Cardiovascular Medicine, 2010.
28 44 American Board of Cardiac Electrophysiology, 2011.
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Clinical Expertise

28 ventricular tachycardia
1b atrial fibrillation
19 catheter ablation
24 supraventricular tachycardia
27 pacemakers (including leadless)
41 defibrillators (including subcutaneous and extravascular)
29 cardiac resynchronization therapy
20 conduction system pacing
2f left atrial appendage closure (Watchman)
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Description of Research Expertise

28 ventricular tachycardia
1b atrial fibrillation
19 catheter ablation
24 supraventricular tachycardia
25 pacing-induced cardiomyopathy
28 cardiac resynchronization therapy
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Selected Publications

b5 Boyle TA, Frankel DS.: Severe acute kidney injury from limited pulsed field ablation. Heart Rhythm Oct 2025.

1ef Shivamurthy P, Cevasco M, Supple GE, Hanumanthu BK, Markman TM, Guandalini G, Hyman MC, Enriquez A, Kumareswaran R, Fradley MG, Deo R, See VY, Riley M, Garcia F, Nazarian S, Lin D, Frankel DS, Dixit S, Epstein AE, Callans DJ, Marchlinski FE, Schaller RD.: Epicardial placement of implantable cardioverter-defibrillators in adults: Technical considerations, system performance, and clinical outcomes. Heart Rhythm Oct 2025.

142 Zghaib T, Enriquez A, Schaller RD, Dixit S, Supple GE, Garcia FC, Callans DJ, Hyman MC, Frankel DS, Marchlinski FE, Nazarian S, Markman TM.: Coronary venous ethanol infusion for treatment of refractory ventricular arrhythmias. Heart Rhythm Sep 2025.

18b Rekapalli P, Oraii A, Heintz J, Dixit S, Epstein AE, Frankel DS, Hyman M, Lin D, Markman T, Messé SR, Nazarian S, Cucchiara B, Schaller RD, See VY, Yang W, Kasner SE, Marchlinski FE, Deo R.: Detection and Significance of Nonsustained Ventricular Tachycardia in a Post-Stroke Population. JACC Clin Electrophysiol Sep 2025.

33b Nguyen O, Wiedrick J, Massera D, Adlestein E, Frejat S, Castrichini M, Alsidawi S, Giudicessi JR, Geske JB, Carrick RT, Madrazo J, Dellise N, Zenker MA, Boyle TA, Reza N, Owens AT, Frankel DS, Hundal P, Tajik J, Galazka P, Lewontin M, Ayers M, Wong T, Flanagan M, Mitter SS, Kanwal A, Bilen O, Baghdadi S, Shah H, Kvapil J, Roldan P, Berenbom L, Jesurum J, Tootill D, Siqueira-Benzow A, Harper M, Saleh D, Choudhury L, Valenta I, Lang M, Phelan DM, Prizand D, Lakdawala N, Ho CY, Liang LW, Weiner SD, Ravi S, Abuzaid AS, Makkiya M, Markowitz JS, Sherrid M, Masri A.: Incidence and Outcomes of Atrial Fibrillation and Systolic Dysfunction in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy: A Multicenter Study. medRxiv Sep 2025.

1eb Chaumont C, Oraii A, Rodriguez-Queralto O, Petzl A, Zado E, Hanumanthu BKJ, Markman TM, Hyman MC, Tschabrunn CM, Enriquez A, Shivamurthy P, Kumareswaran R, Riley MP, Lin D, Schaller RD, Nazarian S, Callans DJ, Supple GE, Garcia FC, Frankel DS, Dixit S, Anselme F, Marchlinski FE.: Sex-Related Differences in Non-Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation. JAMA Netw Open 8: e2529527, Aug 2025.

ec Enriquez A, Frankel DS.: Atrial Fibrillation Ablation in Heart Failure With Mitral Regurgitation: 2 Benefits for the Price of 1. JACC Clin Electrophysiol Aug 2025.

d9 Shaik A, Frankel DS, Khurshid S.: When Close Is Not Close Enough: Cardiomyopathy After Deep Septal Pacing. J Cardiovasc Electrophysiol Aug 2025.

110 Markson FE, Abe TA, Frankel DS, Schaller RD.: Incidence of Pacing-Induced Cardiomyopathy Among Patients With Leadless Versus Transvenous Ventricular Pacemakers. Circ Arrhythm Electrophysiol Aug 2025.

180 Tan JL, Chirinos J, Patel D, Jagasia D, Hyman MC, Guandalini GS, Nazarian S, Lin D, Supple G, Frankel DS, Callans DJ, Marchlinski FE, Ren JF, Markman TM.: Intracardiac echocardiography for left ventricular diastolic function assessment during atrial fibrillation ablation. J Interv Card Electrophysiol Aug 2025.

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26 Last updated: 10/13/2025
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