7b 2d 8 4c 32 Payman Zamani - Faculty Biosketch 30 19 44 9 8 2 1a 2 17
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Payman Zamani, MD, MTR

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Assistant Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
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Department: Medicine
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46 Contact information
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Hospital of The University of Pennsylvania
28 South Pavilion, Floor 11, 11-176
3e 3400 Civic Center Boulevard
Philadelphia, PA 19104
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13 Education:
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2a Dartmouth College, 2001.
21 7 MD 15 (Medicine) c
2f Harvard Medical School, 2007.
21 8 MTR 38 (Master of Science of Translational Research) c
33 University of Pennsylvania, 2015.
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1f Post-Graduate Training
24 61 Intern, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 2007-2008.
24 63 Resident, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 2008-2010.
24 98 Fellow, Advanced Heart Failure and Transplant Cardiology, University of California San Diego Medical Center, San Diego, CA, 2010-2011.
24 7b Fellow, Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 2011-2014.
24 82 Chief Fellow, Cardiovascular Medicine , Hospital of the University of Pennsylvania, Philadelphia, PA, 2013-2014.
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17 Certifications
28 2a Internal Medicine, 2010.
28 30 Cardiovascular Diseases, 2014.
28 49 Advanced Heart Failure and Transplant Cardiology, 2016.
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Description of Clinical Expertise

3d Heart Failure with Reduced Ejection Fraction
36 Heart Failure with Preserved Ejection Fraction
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Description of Research Expertise

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Selected Publications

17f Benyard B, Mathur A, Roy D, Swain A, Kohkhar SK, Soni ND, Wilson N, Haris M, Zamani P, Reddy R, Kumar D: Dual-Breathing CrCEST: A Novel Imaging Method to Distinguish Oxygen Delivery and Utilization in Exercised Muscle. International Society for Magnetic Resonance in Medicine, Cape Town, South Africa May 2026.

17e Rosenbaum M, Allison KC, Laughlin MR, Kelley SS, Nunez-Matos J, Rickles M, Chau L, Wu G, Zamani P, Whyte KJ, Leibel RL, Hayes MR.: The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens. Int J Obes (Lond) Feb 2026 Notes: doi: 10.1038/s41366-025-01944-w.

17c Cohen JB, Hossain A, Chittams J, Zhao M, Afable J, Greenip A, Maynard H, Pourmussa B, Prenner SB, Selvaraj S, Townsend RR, Zamani P, Chirinos JA. : Calcium Channel Blockade versus Beta-Blockade for Hypertension in HFpEF: A Randomized Crossover Trial. Accepted for publication in Hypertension, May 2026 2026.

1fc Lin KY, Bucha A, McSweeney K, Wade KL, Karaj A, Tamaroff J, O’Malley S, Chung NM, Cilenti NA, Wanner J, Adzika GK, Mesaros C, Rojsajjakul T, Blair IA, Serai S, Farmer J, Bryant K, Harhay MO, Lu Y, Paridon SM, Weber DR, Seifert W, Putt ME, Zamani P, Baur JA, Lynch DR, McCormack SE. : Individualized exercise and NAD+ precursor supplementation in Friedreich’s Ataxia: a randomized controlled trial. Lancet: Neurology 25: 469, 2026.

1f5 Vidula MK, Schurgers LJ, Zhao L, Dib MJ, Zhao M, Wang Z, Ebert C, Salman O, Azzo JD, Zamani P, van Empel V, Richards AM, Doughty R, Javaheri A, Mann DL, Rietzschell E, Kammerhoff K, Schafer P, Seiffert DA, Ramirez-Valle F, Cappola TP, Chirinos JA: Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure. Circ Heart Fail 19: e012734, 2026 Notes: DOI: 10.1161/CIRCHEARTFAILURE.124.012734.

18b Vajargah KK, Dib MJ, Tavolinejad H, Zamani P, Richards AM, Mann DL, Rietzschel E, van Empel V, Burgess S, Cappola TP, Chirinos JA. : Proteome-Wide Genetic Investigation of Kidney Function in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail Page: 102771, November 2025 Notes: doi: 10.1016/j.jchf.2025.102771.

85 Saw EL, Werner LD, Cooper H, Pimental DR, Zamani P, Chirinos JA, Valero-Muñoz M, Sam F. 85 : Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction 42 Circ Heart Fail 18(6): e012350, Jun 2025.

1f4 Selvaraj S, Karaj A, Chirinos JA, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner SB, Cohen JB, Ischiropoulos H, Rickels MR, Poole DC, Church DD, Wolfe RR, Kelly DP, Putt M, Margulies KB, Zamani P: Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure with Preserved Ejection Fraction. JACC Heart Fail 13(12): 102435, March 2025.

1c8 Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C, Mohanty I, Miyake MM, Adusumalli S, Margulies KB, Prenner SB, Poole DC, Wilson N, Reddy R, Townsend RR, Ischiropoulos H, Cappola TP, Chirinos JA : Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA Cardiol. 10(3): 284, Mar 2025.

227 Selvaraj S, Karaj A, Chirinos JA, Denney N, Fernando M, Chambers K, Demastus C, Langham M, Maynard H, Pourmussa B, Prenner SB, Cohen J, Ischiropoulos H, Rickels M, Church D, Wolfe R, Kelly DP, Putt ME, Margulies KB, Zamani P.: FUEL UTILIZATION DURING EXERCISE WITH EXOGENOUS KETONES VERSUS PLACEBO IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: KETO-HFPEF. American College of Cardiology Annual Session, March 29-31, 2025; Chicago, IL. March 2025 Notes: Poster presentation.

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