Dr. Nazarian is Professor of Medicine at the Hospital of the University of Pennsylvania and the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:
• Atrial and ventricular arrhythmia substrate identification and ablation
• Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
• Prevention of sudden cardiac death
• Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
• Arrhythmia risk management in patients with neurologic disease
• Management of arrhythmias in cardiac sarcoidosis
• Management of arrhythmias in hypertrophic cardiomyopathy
Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.
Dr. Nazarian is a clinical and translational investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. Dr. Nazarian has been and continues to serve as the principal investigator for several grants from the National Institutes of Health to characterize the substrate for malignant arrhythmia.
Selected Publications
Markman TM, Tschabrunn CM, Callans D, Marchlinski FE, Nazarian S.: Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes. JAMA Cardiol 10: 207-213, Mar 2025.
Zhang Z, Ding Y, Lin K, Ban W, Ding L, Sun Y, Fu C, Ren Y, Han C, Zhang X, Wei X, Hu S, Zhao Y, Cao L, Wang J, Nazarian S, Cao Y, Zheng L, Zhang M, Fu J, Li J, Han X, Qian D, Huang D.: Development of an MRI based artificial intelligence model for the identification of underlying atrial fibrillation after ischemic stroke: a multicenter proof-of-concept analysis. EClinicalMedicine 81: 103118, Feb 2025.
Chaumont C, Petzl AM, Tschabrunn CM, Oraii A, Rodriguez-Queralto O, Sugrue AM, Mirwais M, Markman TM, Supple GE, Hyman MC, Nazarian S, Callans DJ, Garcia FC, Frankel DS, Anselme F, Marchlinski FE.: Ablation of ventricular tachycardia from right ventricular aneurysms in patients with arrhythmogenic cardiomyopathy guided by intracardiac echocardiography. Heart Rhythm Feb 2025.
Zghaib T, Khoshknab M, Markman TM, Marchlinski FE, Epstein AE, Nazarian S.: Contemporary Study of New Onset Atrial Fibrillation Treatment Strategies at a Large Academic Tertiary Care Center. J Cardiovasc Electrophysiol Feb 2025.
Austin MA, Supple GE, Carrell S, Quinn C, Elman L, Nazarian S.: Atrial Fibrillation and Flutter in a Contemporary Cohort of Patients With Myotonic Muscular Dystrophy. JACC Clin Electrophysiol Jan 2025.
Choi SH, Jurgens SJ, Xiao L, Hill MC, Haggerty CM, Sveinbjörnsson G, Morrill VN, Marston NA, Weng LC, Pirruccello JP, Arnar DO, Gudbjartsson DF, Mantineo H, von Falkenhausen AS, Natale A, Tveit A, Geelhoed B, Roselli C, Van Wagoner DR, Darbar D, Haase D, Soliman EZ, Davogustto GE, Jun G, Calkins H, Anderson JL, Brody JA, Halford JL, Barnard J, Hokanson JE, Smith JD, Bis JC, Young K, Johnson LSB, Risch L, Gula LJ, Kwee LC, Chaffin MD, Kühne M, Preuss M, Gupta N, Nafissi NA, Smith NL, Nilsson PM, van der Harst P, Wells QS, Judy RL, Schnabel RB, Johnson R, Smit RAJ, Gabriel S, Knight S, Furukawa T, Blackwell TW, Nauffal V, Wang X, Min YI, Yoneda ZT, Laksman ZWM, Bezzina CR, Alonso A, Psaty BM, Albert CM, Arking DE, Roden DM, Chasman DI, Rader DJ, Conen D, McManus DD, Fatkin D, Benjamin EJ, Boerwinkle E, Marcus GM, Christophersen IE, Smith JG, Roberts JD, Raffield LM, Shoemaker MB, Cho MH, Cutler MJ, Rienstra M, Chung MK, S Olesen M, Sinner MF, Sotoodehnia N, Kirchhof P, Loos RJF, Nazarian S, Mohanty S, Damrauer SM, Kaab S, Heckbert SR, Redline S, Shah SH, Tanaka T, Ebana Y; Regeneron Genetics Center; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Holm H, Stefansson K, et al.: Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk. Nat Genet 2025.
Oraii A, Chaumont C, Rodriguez-Queralto O, Wasiak M, Thind M, Peters CJ, Zado E, Hanumanthu BKJ, Markman TM, Hyman MC, Tschabrunn CM, Guandalini G, Enriquez A, Shivamurthy P, Kumareswaran R, Riley MP, Lin D, Schaller RD, Nazarian S, Callans DJ, Supple GE, Garcia FC, Frankel DS, Dixit S, Marchlinski FE.: Preprocedural Screening Tool to Guide Nonpulmonary Vein Trigger Testing in First-Time Atrial Fibrillation Ablation. Circ Arrhythm Electrophysiol 2025.
Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M, Nafissi NA, Natale A, Nazarian S, Ostrowski SR, Pak HN, Pang S, Pedersen OB, et al.: Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Nat Genet 2025.
Shenoy N, Toloubidokhti M, Gharbia O, Khoshknab MP, Nazarian S, Sapp JL, Singh V, Kapoor A, Wang L.: A Novel 3D Camera-based ECG-Imaging System for Electrode Position Discovery and Heart-Torso Registration. IEEE J Biomed Health Inform PP, Dec 2024.
Toloubidokhti M, Gharbia OA, Parkosa A, Trayanova N, Hadjis A, Tung R, Nazarian S, Sapp JL, Wang L.: Understanding the Utility of Endocardial Electrocardiographic Imaging in Epi-Endocardial Mapping of 3D Reentrant Circuits. medRxiv Nov 2024.
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Last updated: 03/23/2025
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