Dae hyun Lee - Faculty Biosketch

Dae Hyun Lee, MD

Assistant Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania

Department: Medicine

Contact information

3400 Civic Center Blvd
Philadelphia, PA 19104

Email:
daehyun.lee@pennmedicine.upenn.edu

Education:
MD (Premedical-Medical Combined Program)
Inha University, School of Medicine, Incheon, South Korea, 2012.
Bachelor (Statistics and Infromation)
Korean National Open University, Seoul, South Korea, 2017.

Post-Graduate Training
Postdoctoral Research, Einthoven Laboratory of Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands, 2012-2013.
Resident, Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, 2017-2019.
Fellow, Clinical Cardiovascular Training, University of South Florida Morsani College of Medicine, Tampa, FL, 2019-2021.
Fellow, Research Cardiovascular Training, University of South Florida Morsani College of Medicine, Tampa, FL, 2021-2023.
Adjunct Assistant Professor, University of South Florida Morsani College of Medicine, Tampa, FL, 2023-2024.

Certifications
Diplomate of American Board of Internal Medicine, 2020.
Certification Board of Nuclear Cardiology Diplomate, 2022.
Adult Comprehensive Echocardiography, Testamur (COCATS II), 2022.
Cardio-Oncology Board Certification (ICOS), 2023.
Diplomate of ABIM Cardiovascular Disease, 2023.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

My clinical expertise is in improving cardiovascular health for cancer patients and survivors with cardiovascular risk factors, cardiovascular disease, or cardiotoxicity. I work alongside world-class experts in Thalheimer Center for Cardio-Oncology

Description of Research Expertise

The aim of my research is to improve cardiovascular health for cancer patients and survivors. My research interest includes investigating clonal hematopoiesis of indeterminate potential (CHIP) as a mechanism and therapeutic target for cardiovascular health in patients with cancer. I have special expertise in cardiotoxicity in patients undergoing cellular immunotherapy.

Selected Publications

Xie Z, Lee DH, Hansen DK, Loghavi S.: Demystifying the diagnosis and management of ICUS, CHIP, and CCUS. Hematology Am Soc Hematol Educ Program 2025: 682-690, Dec 2025.

Herrmann J, Barac A, Carver J, Cheng RK, Daniele A, Dent S, Deych E, Lee DH, Lenihan D, Leong DP, Liu J, Lopez-Fernandez T, Lyon AR, Fradley M, Macedo AVS, Mooradian MJ, Nohria A, Porter C, Rassaf T, Suero-Abreu G, Sverdlov AL, Thavendiranathan P, Neilan TG, Mitchell JD.: Immune Checkpoint Inhibitor-Associated Cardiovascular Toxic Effects: International Cardio-Oncology Society Position Statement. JAMA Oncol Nov 2025.

Hesterberg RS, Davis JT, Handoo KJ, Elmarsafawi AG, Augello AC, Cheng CH, Atkins R, Lee DH, Yang C, Yao J, Patel KR, Mediavilla-Varela M, Pinilla-Ibarz J, Soto-Palma C, Locke FL, Song X, Wang X, Berglund AE, Rodriguez PC, Knittel G, Flümann R, Reinhardt HC, Shaw TI, Yu X, Niedernhofer LJ, Cleveland JL.: Lymphoma accelerates T cell and tissue aging. Cancer Cell 43: 1917-1936, Oct 2025.

Palfi S, Peres LC, Koelmeyer H, Alsina M, Baz RC, Blue BJ, Corallo S, De Avila G, Freeman C, Gonzalez R, Grajales-Cruz A, Harvey K, Liu HD, Nishihori T, Oliveira GH, Oswald LB, Castaneda Puglianini O, Selvakumar S, Sharma AB, Wang E, Shain KH, Jain M, Locke FL, Alomar M, Hansen DK, Lee DH.: Cardiovascular adverse events and outcomes after anti-BCMA CAR-T for relapsed and refractory multiple myeloma. Blood Cancer J 15: 63, Apr 2025.

Lee DH, Usmani A, Wu R, Wicks T, Noh CY, Burke R, Ravichandran V, Wolf-Doty T, Dumitru I, Oliveira GH, Berman P, Mackie B.: Relationship between donor-derived cell-free DNA and tissue-based rejection-related transcripts in heart transplantation. J Heart Lung Transplant Jul 2024.

Vincelette ND, Yu X, Kuykendall AT, Moon J, Su S, Cheng CH, Sammut R, Razabdouski TN, Nguyen HV, Eksioglu EA, Chan O, Al Ali N, Patel PC, Lee DH, Nakanishi S, Ferreira RB, Hyjek E, Mo Q, Cory S, Lawrence HR, Zhang L, Murphy DJ, Komrokji RS, Lee D, Kaufmann SH, Cleveland JL, Yun S.: Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC-Alarmin Axis. Blood Cancer Discov 5: 276-297, Jul 2024.

Scoma CB, Lee DH, Money D, Eichelberger G, Usmani A, Cohen AJ, Fernandez J.: The Impact of Midodrine on Guideline-Directed Medical Therapy in Patients Admitted With Systolic Heart Failure. J Cardiovasc Pharmacol 83: 353-358, Apr 2024.

Lee DH, Usmani A, Ravichandran V, Wicks T, Wu R, Wolf-Doty T, Dumitru I, Berman P, Oliveira GH, Mackie B.: Relationship between blood and tissue-based rejection-related transcripts in heart transplantation. J Heart Lung Transplant Mar 2024.

Lee DH, Kumar A, Mohammed T, Peres LC, Alsina M, Bachmeier C, Blue BJ, Brayer J, Chandrasekhar S, Grajales Cruz A, De Avila G, Elmariah H, Faramand R, Freeman C, Jain M, Khadka S, Khimani F, Liu H, Nishihori T, Oswald LB, Castaneda Puglianini OA, Shain KH, Smith E, Baz RC, Locke FL, Oliveira GH, Alomar M, Hansen DK.: Cardiac events after standard of care idecabtagene vicleucel for relapsed and refractory multiple myeloma. Blood Adv 7: 4247-4257, Aug 2023.

Alvi RM, Frigault MJ, Fradley MG, Jain MD, Mahmood SS, Awadalla M, Lee DH, Zlotoff DA, Zhang L, Drobni ZD, Hassan MZO, Bassily E, Rhea I, Ismail-Khan R, Mulligan CP, Banerji D, Lazaryan A, Shah BD, Rokicki A, Raje N, Chavez JC, Abramson J, Locke FL, Neilan TG.: Cardiovascular Events Among Adults Treated With Chimeric Antigen Receptor T-Cells (CAR-T). J Am Coll Cardiol 74: 3099-3108, Dec 2019.