Selected Publications

Hamilton AG, Thatte AS, Xu J, Luo Z, Safford HC, Swingle KL, Muscat-Rivera J, Kegel M, Han X, Joseph RA, Murray AM, Geisler HC, Whitaker RC, Xue L, Spektor R, Melamed JR, Weissman D, Mitchell MJ.: High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering. Adv Mater 2026.

Sterin EH, Kramarenko GC, Roy Chowdhury C, Tendulkar SP, Li K, Chaya T, Muscat-Rivera J, Melamed JR, Day ES.: Exogenous CD55 Expression on Membrane-Wrapped Nanoparticles Unexpectedly Increases Spleen Tropism and Immune Cell Uptake In Vivo. ACS Nano Med 1: 283-296, Nov 2025.

Nakamichi S, von Muhlinen N, Yamada L, Melamed JR, Papp TE, Parhiz H, Weissman D, Horikawa I, Harris CC.: SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer. Carcinogenesis 46: bgaf082, Nov 2025.

Melamed JR, Muscat-Rivera J, Kegel M, Chaboub LS, Perez-Tremble R, Bhalla NS, Ni H, Sun H, Weissman D.: Anionic lipids modulate mRNA-lipid nanoparticle immunogenicity and confer protection in a mouse model of multiple sclerosis. bioRxiv Oct 2025.

Rochman Y, Kotliar M, Klingler AM, Rochman M, Alameh MG, Melamed JR, Osswald GA, Caldwell JM, Felton JM, Mack LE, Hargis J, Lewkowich IP, Barski A, Weissman D, Rothenberg ME.: Allergen-specific mRNA-lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice. J Clin Invest 135: e194080, Sep 2025.

Razavi R, Kegel M, Muscat-Rivera J, Weissman D, Melamed JR.: Harnessing mRNA-lipid nanoparticles as innovative therapies for autoimmune diseases. Mol Ther Methods Clin Dev 33: 101566, Aug 2025.

Doerfler R, Yerneni S, LoPresti S, Chaudhary N, Newby A, Melamed JR, Malaney A, Whitehead KA.: Maternal milk cell components are uptaken by infant liver macrophages via extracellular vesicle mediated transport. FASEB J 39: e70340, Jan 2025.

Chaudhary N, Kasiewicz LN, Newby AN, Arral ML, Yerneni SS, Melamed JR, LoPresti ST, Fein KC, Strelkova Petersen DM, Kumar S, Purwar R, Whitehead KA.: Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d. Nat Biomed Eng 2024.

Omo-Lamai S, Zamora ME, Patel MN, Wu J, Nong J, Wang Z, Peshkova A, Majumder A, Melamed JR, Chase LS, Essien EO, Weissman D, Muzykantov VR, Marcos-Contreras OA, Myerson JW, Brenner JS.: Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions. Adv Mater 2024.

Jilian R Melamed, Saigopalakrishna S Yerneni, Mariah L Arral, Samuel T LoPresti, Namit Chaudhary, Anuradha Sehrawat, Hiromi Muramatsu, Mohamad-Gabriel Alameh, Norbert Pardi, Drew Weissman, George K Gittes, Kathryn A Whitehead: Ionizable lipid nanoparticles deliver mRNA to pancreatic beta cells via macrophage-mediated gene transfer. Science Advances 9(4): eade1444, Jan 2023.