Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness and populations.
Dr. Shashaty has formal training in the clinical practice of pulmonary and critical care medicine, biostatistical and epidemiologic methods, and protein, gene expression, and genomic analyses of human biospecimens. He is the principal investigator for the Lung Transplant Outcomes Group–Acute Kidney Injury (LTOG-AKI) study, a multicenter prospective cohort of lung transplant recipients (n>1800) designed to study the clinical and molecular epidemiology of post-lung transplant AKI. The primary focus of this study is to determine clinical characteristics and novel blood and urine biomarkers that are useful for AKI prediction and may provide insight into molecular mechanisms of AKI after transplantation.
Dr. Shashaty is also the principal investigator for the ongoing Penn Trauma Organ Dysfunction Study (PETROS), a cohort of critically ill trauma patients (n>1300), and a co-investigator in Penn’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, for which he leads studies of AKI. Current areas of study in these cohorts include elucidating mechanisms underlying the association of obesity and AKI, the relevance of programmed cell necrosis in human AKI and ARDS, circulating cell-free DNA as a mechanistic contributor to AKI and ARDS, and genetic risk factors for AKI.
Dr. Shashaty is specialty-trained in internal medicine, pulmonary diseases, and critical care medicine. He is an attending physician at the Hospital of the University of Pennsylvania (HUP), with the majority of his clinical time spent in the medical intensive care unit. He also attends on and is the service lead for the Critical Care Outreach and Procedure Service (CCOPS).
Dr. Shashaty is currently the Rapid Response Medical Director at HUP. In this capacity, he works with a multidisciplinary team to provide oversight, design and conduct training, and pursue quality improvement initiatives in the areas of clinical emergencies and management of cardiac arrest. He has played a central role in adapting HUP's clinical emergencies team to the COVID-19 pandemic.
Dr. Shashaty is actively engaged in teaching fellows, house officers, medical students, and advanced practice providers through both HUP clinical services, classes at the Perelman School of Medicine, and training programs at the Penn School of Nursing.
Selected Publications
Reilly JP, Shashaty MGS, Miano TA, Giannini HM, Jones TK, Ittner CAG, Christie JD, Meyer NJ.: ABO Histo-Blood Group and the von Willebrand Factor Axis in Severe COVID-19. CHEST Crit Care Dec 2023.
Diamond JM, Anderson MR, Cantu E, Clausen ES, Shashaty MGS, Kalman L, Oyster, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Lama VN, Patel MG, Singer JP, Hachem RR, Michelson AP, Hsu J, A Russell Localio AR, Christie JD: Development and Validation of Primary Graft Dysfunction Predictive Algorithm for Lung Transplant Candidates. Journal of Heart and Lung Transplantation Nov 2023 Notes: in press.
Diamond JM, Cantu E, Calfee CS, Anderson MR, Clausen ES, Shashaty MGS, Courtwright AM, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Todd JL, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Weinacker AB, Lama VN, Patel MG, Singer JP, Hsu J, Localio AR, Christie JD.: The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation. Am J Respir Crit Care Med Sep 2023.
Anderson MR, Diamond J, Shashaty M, Singer JP, Tong Y, Udupa J, Torigian DA, Palmer S, Lederer DJ, Christie JD, Al-Naamani N.: Accuracy and Reproducibility of Automated Measurement of Body Composition: A Lung Transplant Body Composition Cohort Study. Ann Am Thorac Soc 20(9): 1363-1366, Sep 2023.
Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Turner AP, Agyekum RS, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: Acute Respiratory Distress Syndrome Mediates the Association between Early Plasma Soluble Receptor for Advanced Glycation End Products Concentrations and Mortality in Sepsis. Am J Respir Crit Care Med 208: 628-630, Sep 2023.
Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Jones TK, Anderson BJ, Ittner CA, Dunn T, Miano TA, Oniyide O, Balmes JR, Matthay MA, Calfee CS, Christie JD, Meyer NJ, Ware LB.: Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis. Intensive Care Med Aug 2023.
Anderson MR, Cantu E, Shashaty M, Benvenuto L, Kalman L, Palmer S, Singer JP, Gallop R, Diamond JM, Hsu J, Localio AR, Christie JD.: Body Mass Index and Cause-specific Mortality after Lung Transplantation in the United States. Ann Am Thorac Soc 20(6): 825-833, Jun 2023.
CV Cosgriff, TA Miano, D Mathew, AC Huang, HM Giannini, L Kuri-Cervantes, MB Pampena, CAG Ittner, AR Weisman, RS Agyekum, TG Dunn, O Oniyide, AP Turner, K D’Andrea, S Adamski, AR Greenplate, BJ Anderson, MO Harhay, TK Jones, JP Reilly, NS Mangalmurti, MGS Shashaty, MR Betts, EJ Wherry, NJ Meyer: Validating a Proteomic Signature of Severe COVID-19. Critical Care Explorations 4(12): e0800, Dec 2022.
Mitchell OJL, Neefe S, Ginestra JC, Schweickert WD, Falk S, Weissman GE, Covin D, Shults J, Abella BS, Shashaty MGS.: Association of Time to Rapid Response Team Activation With Patient Outcomes Using a Range of Physiologic Deterioration Thresholds. Crit Care Explor 4: e0786, Nov 2022.
Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS.: Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Med Jul 2022.
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Last updated: 11/25/2024
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